CAS 608-31-1

2,6-Dichloroaniline

Codes：(I)122568-1-a、(VI)122568-3-a、(III)122568-4-a、(V)122568-5-a

Application context (from source-drug indications)

注意力缺陷障碍伴多动盐酸可乐定 (Tris Pharma)高血压盐酸可乐定 (Tris Pharma)

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
盐酸可乐定 (Tris Pharma)Clonidine Hydrochloride (Tris Pharma)	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

盐酸可乐定 (Tris Pharma)优化路线steps: 3total yield: /

2,6-Dichloroaniline→(2,6-dichlorophenyl)thiourea→N-[(2,6-Dichlorophenyl)carbamothioyl]benzamide→Methyl N-(2,6-dichlorophenyl)carbamimidothioate hydrogen iodide→1,2-Diaminoethane

盐酸可乐定 (Tris Pharma)优化路线steps: 4total yield: /

1-Chloro-2-nitrobenzene→N-(2-chlorophenyl)hydroxylamine→Formic acid→N-(2-Chlorophenyl)-N-hydroxyformamide→2,6-Dichloroaniline→N-(2,6-Dichlorophenyl)formamide→1,2-Diaminoethane

盐酸可乐定 (Tris Pharma)优化路线steps: 2total yield: /

2-Mercaptoimidazoline→4,5-Dihydro-1H-imidazole-2-sulfonic acid→2,6-Dichloroaniline

盐酸可乐定 (Tris Pharma)优化路线steps: 3total yield: /

2-Mercaptoimidazoline→1,1-Dimethylethyl monobromoacetate→tert-Butyl [(4,5-dihydro-1H-imidazol-2-yl)sulfanyl]acetate hydrogen bromide→Methyl 2-[(2-tert-butoxy-2-oxoethyl)sulfanyl]-4,5-dihydro-1H-imidazole-1-carboxylate→2,6-Dichloroaniline

Intermediates available on this site

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