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苯磺酸左旋氨氯地平

Tier C — Watch / trade

Levamlodipine Besylate

Ahn-Gook
Originator
2006
First approval
-
Expiry (public)
No sales data
Peak sales
化学药
Type

Targets：VDCCs

Brand：Levotension

Indications (approved)：高血压、心绞痛

Regional status

US
-
EU
-
China
批准上市
2011-01-28
Japan
-

Synthetic routes & intermediates5 routes

Originator routes × 0Optimised (non-patent) × 5Process routes × 0

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OptimisedRoute 1Steps 5 · Total yield 12.7g(Levamlodipine Besylate (API))
Synthetic routes & intermediates Route 1
CodeCAS No.Intermediate
Levamlodipine Besylate-001111470-99-6,88150-42-9(±)-2-(2-Aminoethoxymethyl)-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine
Levamlodipine Besylate-002-Bis[3-ethyl 5-methyl (4S)-2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate] (2S,3S)-2,3-dihydroxybutanedioic acid urea
Levamlodipine Besylate-003103129-82-43-Ethyl 5-methyl (4S)-2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
Levamlodipine Besylate-004-(2S,3S)-2,3-Dihydroxybutanedioic acid 3-ethyl 5-methyl (4S)-2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate (1/2)
Levamlodipine Besylate-005-(2R,3R)-2,3-Dihydroxybutanedioic acid 3-ethyl 5-methyl (4S)-2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate (1/2)
OptimisedRoute 2Steps 4 · Total yield /
Synthetic routes & intermediates Route 2
CodeCAS No.Intermediate
Levamlodipine Besylate-006221446-45-33-Ethyl 5-methyl 2-[(2-chloroethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
Levamlodipine Besylate-007906098-03-15-Ethyl 3-methyl 4-(2-chlorophenyl)-2-methyl-6-[(2-nitroethoxy)methyl]-1,4-dihydropyridine-3,5-dicarboxylate
Levamlodipine Besylate-001111470-99-6,88150-42-9(±)-2-(2-Aminoethoxymethyl)-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine
Levamlodipine Besylate-00888150-75-8Ethyl 4-(2-phthalimidoethoxy)acetoacetate
Levamlodipine Besylate-00914205-39-13-Amino-2-butenoic acid methyl ester
Levamlodipine Besylate-01089-98-52-Chlorobenzaldehyde
Levamlodipine Besylate-011103094-30-0,88150-62-33-Ethyl 5-methyl (4RS)-4-(2-chlorophenyl)-2-[[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethoxy]methyl]-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
OptimisedRoute 3Steps 2 · Total yield 9.98g(Amlodipine (Free))
Synthetic routes & intermediates Route 3
CodeCAS No.Intermediate
Levamlodipine Besylate-012-1-tert-Butyl 3-ethyl 5-methyl 2-([2-[(tert-butoxycarbonyl)amino]ethoxy]methyl)-6-methylpyridine-1,3,5(4H)-tricarboxylate
Levamlodipine Besylate-013615-41-81-Chloro-2-iodobenzene
Levamlodipine Besylate-014-2-(2-Chlorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
Levamlodipine Besylate-015-2-(2-Chlorophenyl)-4,4-dimethyl-1,3,2-dioxaborolane
Levamlodipine Besylate-016-2-(2-Chlorophenyl)-1,3,2-dioxaborolane
Levamlodipine Besylate-017-1-tert-Butyl 3-ethyl 5-methyl 2-([2-[(tert-butoxycarbonyl)amino]ethoxy]methyl)-4-(2-chlorophenyl)-6-methylpyridine-1,3,5(4H)-tricarboxylate
Levamlodipine Besylate-00188150-42-9,111470-99-6(±)-2-(2-Aminoethoxymethyl)-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine
OptimisedRoute 4Steps 1 · Total yield 17.8g(Levamlodipine Maleate (API))
Synthetic routes & intermediates Route 4
CodeCAS No.Intermediate
Levamlodipine Besylate-001111470-99-6,88150-42-9(±)-2-(2-Aminoethoxymethyl)-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine
Levamlodipine Besylate-018-(4S)-2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate (2Z)-but-2-enedioic acid 3-ethyl 5-methyl
OptimisedRoute 5Steps 5 · Total yield /
Synthetic routes & intermediates Route 5
CodeCAS No.Intermediate
Levamlodipine Besylate-019147357-20-83,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-, 3-ethyl 5-methyl ester
Levamlodipine Besylate-020-3-ethyl 5-methyl 4-bromo-2-(bromomethyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
Levamlodipine Besylate-0213891-07-4N-Hydroxyethylphthalimide
Levamlodipine Besylate-022-3-ethyl 5-methyl 4-bromo-2-((2-(1,3-dioxoisoindolin-2-yl)ethoxy)methyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
Levamlodipine Besylate-0233900-89-82-Chlorophenylboronic acid
Levamlodipine Besylate-02488150-62-3Phthaloyl amlodipine
Levamlodipine Besylate-00188150-42-9,111470-99-6(±)-2-(2-Aminoethoxymethyl)-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine

Frequently asked questions

What are the approved indications of Levamlodipine Besylate?

Approved indications include: 高血压, 心绞痛.

When does the Levamlodipine Besylate patent expire?

No public expiry year is available for Levamlodipine Besylate yet; this page updates once verified.

How many synthesis routes are recorded for Levamlodipine Besylate?

5 synthesis routes are recorded; the shortest is 1 steps with 17.8g(Levamlodipine Maleate (API)) total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Levamlodipine Besylate intermediates?

All intermediates in Levamlodipine Besylate routes have CAS profiles — you can submit an RFQ per CAS and it enters the Unibest matching pool.

How do I get a quote for Levamlodipine Besylate intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-24