CAS 641571-11-1

3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

Codes：RADO-006、RADO-010

Application context (from source-drug indications)

慢性髓细胞白血病拉多替尼二盐酸盐费城染色体拉多替尼二盐酸盐髓系白血病慢性期拉多替尼二盐酸盐髓样白血病拉多替尼二盐酸盐帕金森病拉多替尼二盐酸盐白血病拉多替尼二盐酸盐

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
拉多替尼二盐酸盐Radotinib Dihydrochloride	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

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拉多替尼二盐酸盐原研路线steps: 5total yield: /

ethyl 3-amino-4-methylbenzoate→ethyl 3-guanidino-4-methylbenzoate nitrate→(E)-3-(dimethylamino)-1-(pyrazin-2-yl)prop-2-en-1-one→ethyl 4-methyl-3-((4-(pyrazin-2-yl)pyrimidin-2-yl)amino)benzoate→4-methyl-3-((4-(pyrazin-2-yl)pyrimidin-2-yl)amino)benzoic acid→3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline→3-bromo-5-(trifluoromethyl)aniline→4-methyl-1H-imidazole

拉多替尼二盐酸盐优化路线steps: 1total yield: 18.7 g

ethyl 4-methyl-3-((4-(pyrazin-2-yl)pyrimidin-2-yl)amino)benzoate→3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

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Supplier	Product	Price band	MOQ	Lead time	Qualifications
Unibest Nantong cGMP Site	3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline Pharmaceutical Intermediates	询价	询价	询价	—

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