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CAS 77-76-9
2,2-dimethoxypropane1-Methoxy-1-methylethyl methyl ether
Codes：TICA-019、(VII)140605-2-a、Atorvastatin-083
Application context (from source-drug indications)
中风替格瑞洛急性冠脉综合征替格瑞洛心肌梗塞替格瑞洛外周血管疾病替格瑞洛膀胱癌多西他赛纳米胶束 (Samyang Biopharmaceuticals)头颈癌多西他赛纳米胶束 (Samyang Biopharmaceuticals)头颈部鳞状细胞癌多西他赛纳米胶束 (Samyang Biopharmaceuticals)实体瘤多西他赛纳米胶束 (Samyang Biopharmaceuticals)高脂血症阿托伐他汀锶蛛网膜下腔出血阿托伐他汀锶高血压阿托伐他汀锶
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 替格瑞洛Ticagrelor | Tier B — Position early | 2029 |
| 多西他赛纳米胶束 (Samyang Biopharmaceuticals)Docetaxel polymeric micelle (Samyang Biopharmaceuticals) | Tier C — Watch / trade | - |
| 阿托伐他汀锶Atorvastatin strontium | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
4,6-dichloro-5-nitro-2-(propylthio)pyrimidine→(3aR,4S,6R,6aS)-6-amino-2,2-dimethyltetrahydro-4H-cyclopenta[d][1,3]dioxol-4-ol→(3aR,4S,6R,6aS)-6-((6-chloro-5-nitro-2-(propylthio)pyrimidin-4-yl)amino)-2,2-dimethyltetrahydro-4H-cyclopenta[d][1,3]dioxol-4-ol→(3aR,4S,6R,6aS)-6-((5-amino-6-chloro-2-(propylthio)pyrimidin-4-yl)amino)-2,2-dimethyltetrahydro-4H-cyclopenta[d][1,3]dioxol-4-ol→(3aR,4S,6R,6aS)-6-(7-chloro-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyltetrahydro-4H-cyclopenta[d][1,3]dioxol-4-ol→(3aR,4S,6R,6aS)-6-(7-amino-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyltetrahydro-4H-cyclopenta[d][1,3]dioxol-4-ol→methyl 2-(((trifluoromethyl)sulfonyl)oxy)acetate→methyl 2-(((3aR,4S,6R,6aS)-6-(7-amino-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyltetrahydro-4H-cyclopenta[d][1,3]dioxol-4-yl)oxy)acetate→methyl 2-(((3aR,4S,6R,6aS)-6-(7-bromo-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyltetrahydro-4H-cyclopenta[d][1,3]dioxol-4-yl)oxy)acetate→(1R,2S)-2-(3,4-difluorophenyl)cyclopropan-1-amine→methyl 2-(((3aR,4S,6R,6aS)-6-(7-(((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyltetrahydro-4H-cyclopenta[d][1,3]dioxol-4-yl)oxy)acetate→potassium sodium (2R,3R)-2,3-dihydroxysuccinate→2-(((3aR,4S,6R,6aS)-6-(7-(((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyltetrahydro-4H-cyclopenta[d][1,3]dioxol-4-yl)oxy)ethan-1-ol→(1R,4S)-4-hydroxycyclopent-2-en-1-yl acetate→TICA-015→TICA-016→4-methylmorpholine 4-oxide→TICA-018→2,2-dimethoxypropane
(S)-(+)-2-Phenylglycine→Methyl trifluoromethanesulfonate→Bis(1,1-dimethylethyl) dicarbonoate→(S)-N-Boc-phenylglycine methyl ester→N-(tert-Butoxycarbonyl)-L-2-phenylglycinal→2-(trimethylsilyl)-1,3-thiazole→tert-butyl N-[(1S,2R)-2-hydroxy-1-phenyl-2-(1,3-thiazol-2-yl)ethyl]carbamate→1-Methoxy-1-methylethyl methyl ether→tert-butyl (4S,5R)-2,2-dimethyl-4-phenyl-5-(1,3-thiazol-2-yl)-1,3-oxazolidine-3-carboxylate→tert-butyl (4S,5R)-5-formyl-2,2-dimethyl-4-phenyl-1,3-oxazolidine-3-carboxylate→(4S,5R)-3-(tert-Butoxycarbonyl)-2,2-dimethyl-4-phenyl-1,3-oxazolidine-5-carboxylic acid
Methyl (3S)-4-chloro-3-hydroxybutanoate→Methyl (3S)-4-chloro-3-[(trimethylsilyl)oxy]butanoate→(3S)-4-Chloro-3-[(trimethylsilyl)oxy]butanal→tert-Butyl (3R,5S)-6-chloro-3,5-dihydroxyhexanoate→tert-Butyl [(4R,6S)-6-(chloromethyl)-2,2-dimethyl-1,3-dioxan-4-yl]acetate→[(4S,6R)-6-[2-(tert-Butoxy)-2-oxoethyl]-2,2-dimethyl-1,3-dioxan-4-yl]methyl acetate→1,1-Dimethylethyl acetate→1-Methoxy-1-methylethyl methyl ether
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