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CAS 87-13-8
diethyl 2-(ethoxymethylene)malonate
Codes：AVAN-001、IVAC-002
Application context (from source-drug indications)
勃起功能障碍阿伐那非囊性纤维化艾伐卡托慢性支气管炎艾伐卡托慢性阻塞性肺疾病艾伐卡托鼻窦炎艾伐卡托
Source drugs (routes using this intermediate)
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
diethyl 2-(ethoxymethylene)malonate→methyl carbamimidothioate→ethyl 4-hydroxy-2-(methylthio)pyrimidine-5-carboxylate→ethyl 4-chloro-2-(methylthio)pyrimidine-5-carboxylate→(3-chloro-4-methoxyphenyl)methanamine hydrochloride→ethyl 4-((3-chloro-4-methoxybenzyl)amino)-2-(methylthio)pyrimidine-5-carboxylate→ethyl 4-((3-chloro-4-methoxybenzyl)amino)-2-(methylsulfinyl)pyrimidine-5-carboxylate→(S)-pyrrolidin-2-ylmethanol→ethyl (S)-4-((3-chloro-4-methoxybenzyl)amino)-2-(2-(hydroxymethyl)pyrrolidin-1-yl)pyrimidine-5-carboxylate→(S)-4-((3-chloro-4-methoxybenzyl)amino)-2-(2-(hydroxymethyl)pyrrolidin-1-yl)pyrimidine-5-carboxylic acid→pyrimidin-2-ylmethanamine hydrochloride
diethyl 2-(ethoxymethylene)malonate→(3-chloro-4-methoxyphenyl)methanamine hydrochloride→(S)-pyrrolidin-2-ylmethanol→pyrimidin-2-ylmethanamine→thiourea→AVAN-027→AVAN-028→AVAN-029→AVAN-030→AVAN-031→AVAN-032→AVAN-033
aniline→diethyl 2-(ethoxymethylene)malonate→diethyl 2-((phenylamino)methylene)malonate→ethyl 4-oxo-1,4-dihydroquinoline-3-carboxylate→4-oxo-1,4-dihydroquinoline-3-carboxylic acid→5-amino-2,4-di-tert-butylphenol→2,4-di-tert-butylphenol→2,4-di-tert-butylphenyl methyl carbonate→2,4-di-tert-butyl-5-nitrophenyl methyl carbonate→2,4-di-tert-butyl-5-nitrophenol
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