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CAS 89336-46-9
2-(2-((tert-butoxycarbonyl)amino)thiazol-4-yl)acetic acid
Codes：MIRA-022
Application context (from source-drug indications)
神经性膀胱功能障碍米拉贝隆膀胱过度活动症米拉贝隆
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 米拉贝隆Mirabegron | Tier B — Position early | 2029 |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
(R)-2-amino-1-phenylethanol→2-(2-aminothiazol-4-yl)acetic acid hydrochloride→2-(2-((tert-butoxycarbonyl)amino)thiazol-4-yl)acetic acid→2-(2-(benzylamino)thiazol-4-yl)acetic acid→2-(2-((ethoxycarbonyl)amino)thiazol-4-yl)acetic acid→4-(2-bromoethyl)aniline hydrochloride→4-(2-chloroethyl)aniline hydrochloride→tert-butyl (4-(2-((4-(2-bromoethyl)phenyl)amino)-2-oxoethyl)thiazol-2-yl)carbamate→2-(2-(benzylamino)thiazol-4-yl)-N-(4-(2-bromoethyl)phenyl)acetamide→ethyl (4-(2-((4-(2-chloroethyl)phenyl)amino)-2-oxoethyl)thiazol-2-yl)carbamate→tert-butyl (4-(2-((4-(2-chloroethyl)phenyl)amino)-2-oxoethyl)thiazol-2-yl)carbamate→tert-butyl (R)-(4-(2-((4-(2-((2-hydroxy-2-phenylethyl)amino)ethyl)phenyl)amino)-2-oxoethyl)thiazol-2-yl)carbamate→(R)-2-(2-(benzylamino)thiazol-4-yl)-N-(4-(2-((2-hydroxy-2-phenylethyl)amino)ethyl)phenyl)acetamide→ethyl (R)-(4-(2-((4-(2-((2-hydroxy-2-phenylethyl)amino)ethyl)phenyl)amino)-2-oxoethyl)thiazol-2-yl)carbamate
2-(4-aminophenyl)ethanol→(R)-2-amino-1-phenylethanol→2-(2-aminothiazol-4-yl)acetic acid hydrochloride→2-(2-((tert-butoxycarbonyl)amino)thiazol-4-yl)acetic acid→tert-butyl (R)-(4-(2-((4-(2-((2-hydroxy-2-phenylethyl)amino)ethyl)phenyl)amino)-2-oxoethyl)thiazol-2-yl)carbamate→2-(2-(((benzyloxy)carbonyl)amino)thiazol-4-yl)acetic acid→2-(2-(tritylamino)thiazol-4-yl)acetic acid→tert-butyl (4-(2-((4-(2-hydroxyethyl)phenyl)amino)-2-oxoethyl)thiazol-2-yl)carbamate→benzyl (4-(2-((4-(2-hydroxyethyl)phenyl)amino)-2-oxoethyl)thiazol-2-yl)carbamate→N-(4-(2-hydroxyethyl)phenyl)-2-(2-(tritylamino)thiazol-4-yl)acetamide→tert-butyl (4-(2-oxo-2-((4-(2-oxoethyl)phenyl)amino)ethyl)thiazol-2-yl)carbamate→benzyl (4-(2-oxo-2-((4-(2-oxoethyl)phenyl)amino)ethyl)thiazol-2-yl)carbamate→N-(4-(2-oxoethyl)phenyl)-2-(2-(tritylamino)thiazol-4-yl)acetamide→benzyl (R)-(4-(2-((4-(2-((2-hydroxy-2-phenylethyl)amino)ethyl)phenyl)amino)-2-oxoethyl)thiazol-2-yl)carbamate→(R)-2-(2-((l1-phosphanyl)amino)thiazol-4-yl)-N-(4-(2-((2-hydroxy-2-phenylethyl)amino)ethyl)phenyl)acetamide
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