CAS 91714-94-2,91714-93-1

[2-Amino-3-(4-bromobenzoyl)phenyl]acetic acid

Codes: Bromfenac Sodium-007, Bromfenac Sodium-040

Application context (from source-drug indications)

Inflammatory diseaseBromfenac SodiumPostoperative painBromfenac Sodium眼睛发炎Bromfenac Sodium眼睛疼痛Bromfenac SodiumDry eye syndromeBromfenac Sodium黄斑水肿Bromfenac Sodium

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Bromfenac Sodium	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Bromfenac SodiumProcess routesteps: 4total yield: 1.46kg(Bromfenac (Free))

para-Bromobenzeneboronic acid→Anthranilonitrile→2-Amino-4'-bromobenzophenone→Ethyl alpha-(methylthio)acetate→7-(4-Bromobenzoyl)-3-(methylsulfanyl)-1,3-dihydro-2H-indol-2-one→7-(4-Bromobenzoyl)-1,3-dihydro-2-indolone→[2-Amino-3-(4-bromobenzoyl)phenyl]acetic acid

Bromfenac SodiumProcess routesteps: 7total yield: 0.963kg(Bromfenac Sodium (API))

(4-Bromophenyl)(7-indolyl)methanone→(4-Bromophenyl)(3-chloro-1H-indol-7-yl)methanone→(3-Bromo-1H-indol-7-yl)(4-bromophenyl)methanone→7-(4-Bromobenzoyl)-1,3-dihydro-2-indolone→7-(4-Bromobenzoyl)-3,3-dichloro-1,3-dihydro-2H-indol-2-one→3,3-Dibromo-7-(4-bromobenzoyl)-1,3-dihydro-2H-indol-2-one→[2-Amino-3-(4-bromobenzoyl)phenyl]acetic acid

Bromfenac SodiumProcess routesteps: 7total yield: 493g(Bromfenac Sodium (API))

1H-Indole→3-Bromoindole→1,3-Dihydroindolone→4-Bromobenzonitrile→7-(4-Bromobenzoyl)-1,3-dihydro-2-indolone→[2-Amino-3-(4-bromobenzoyl)phenyl]acetic acid→2-Amino-3-benzoylbenzeneacetic acid sodium salt monohydrate→(2-Amino-3-benzoylphenyl)acetic acid

Bromfenac SodiumOptimised routesteps: 4total yield: 16.9g(Bromfenac Sodium (API))

Methyl 4-bromobenzoate→4-Bromobenzoic acid ethyl ester→Methyl 3-(2-methoxy-2-oxoethyl)-2-oxocyclohexane-1-carboxylate→Ethyl 3-(2-ethoxy-2-oxoethyl)-2-oxocyclohexane-1-carboxylate→[3-(4-Bromobenzoyl)-2-oxocyclohexyl]acetic acid→[1,3-Dibromo-3-(4-bromobenzoyl)-2-oxocyclohexyl]acetic acid→[3-(4-Bromobenzoyl)-1,3-dichloro-2-oxocyclohexyl]acetic acid→[2-Amino-3-(4-bromobenzoyl)phenyl]acetic acid

Bromfenac SodiumOptimised routesteps: 5total yield: 27.9g(Bromfenac Sodium (API))

(2-Aminophenyl)acetic acid→(2-Acetamidophenyl)acetic acid→(2-Acetamido-5-sulfophenyl)acetic acid→4-Bromobenzoyl chloride→[2-Acetamido-3-(4-bromobenzoyl)-5-sulfophenyl]acetic acid→[2-Amino-3-(4-bromobenzoyl)phenyl]acetic acid

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