CAS 98475-07-1

methyl 2-(bromomethyl)-3-nitrobenzoate

Codes：LENA-003

Application context (from source-drug indications)

边缘带B细胞淋巴瘤来那度胺滤泡性淋巴瘤来那度胺成人T细胞白血病淋巴瘤来那度胺套细胞淋巴瘤来那度胺骨髓增生异常综合征来那度胺多发性骨髓瘤来那度胺

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
来那度胺Lenalidomide	Tier B — Position early	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

来那度胺原研路线steps: 5total yield: 0.46 g

methyl 2-methyl-3-nitrobenzoate→1-bromopyrrolidine-2,5-dione→methyl 2-(bromomethyl)-3-nitrobenzoate→(tert-butoxycarbonyl)-L-glutamine→(R)-2-((tert-butoxycarbonyl)amino)-5-(4-nitro-1-oxoisoindolin-2-yl)-5-oxopentanoic acid→(R)-2-amino-5-(4-nitro-1-oxoisoindolin-2-yl)-5-oxopentanoic acid→3-(4-nitro-1-oxoisoindolin-2-yl)piperidine-2,6-dione

来那度胺优化路线steps: 5total yield: 1.12 g

methyl 2-(bromomethyl)-3-nitrobenzoate→4-nitroisoindolin-1-one→4-aminoisoindolin-1-one→dimethyl 2-bromopentanedioate→dimethyl 2-(4-amino-1-oxoisoindolin-2-yl)pentanedioate→glutaric acid

Intermediates available on this site

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Supplier	Product	Price band	MOQ	Lead time	Qualifications
Qualified Partner — East China API Works	methyl 2-(bromomethyl)-3-nitrobenzoate Pharmaceutical Intermediates	询价	询价	询价	—

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