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（S）-泮托拉唑钠
Tier C · 观察 / 贸易S-pantoprazole sodium
Ahn-Gook
原研
2006
首批上市
-
到期年（公开口径）
无销量数据
峰值销售
化学药
类型
靶点：H+/K+ ATPase
商品名：Letopra、Panpure
适应症（已批准）：胃食管反流病、消化性溃疡
各地区研发/上市状态
美国
-
欧盟
-
中国
临床一期
2017-05-11
日本
-
合成路线与中间体17 routes
原研路线 × 0优化路线（非专利）× 16工艺路线 × 1
路线按「原研路线 → 优化路线 / 工艺路线（非专利）」排序。每条路线附本站自绘的路线流程图（中间体 → 原料药）与中间体表（编号 / CAS / 英文名），可直接用于供应商开发与询价。流程图由本站依据已授权的结构化数据自行渲染，未使用任何第三方路线图。
优化Route 1步骤 3 · 总收率 4g((S)-(-)-Pantoprazole sodium (API))
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| S-pantoprazole sodium-001 | - | potassium (ethoxymethanethioyl)sulfanide |
| S-pantoprazole sodium-002 | 172282-50-7 | 1,2-Diamino-4-(difluoromethoxy)benzene |
| S-pantoprazole sodium-003 | 142470-46-0 | 5-(Difluoromethoxy)-1H-benzimidazole-2-thiol |
| S-pantoprazole sodium-004 | 169905-10-6 | 2-(chloromethyl)-3,4-dimethoxypyridine |
| S-pantoprazole sodium-005 | 142470-47-1 | 5-(Difluoromethoxy)-2-{[(3,4-dimethoxypyridin-2-yl)methyl]sulfanyl}-1H-benzimidazole |
优化Route 2步骤 3 · 总收率 /
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| S-pantoprazole sodium-006 | 104819-52-5 | 2-bromo-3,4-dimethoxypyridine |
| S-pantoprazole sodium-007 | 142488-36-6 | 3,4-dimethoxypyridine-2-carbonitrile |
| S-pantoprazole sodium-008 | - | methyl 3,4-dimethoxypyridine-2-carboxylate |
| S-pantoprazole sodium-009 | 169905-10-6 | 2-(chloromethyl)-3,4-dimethoxypyridine |
优化Route 3步骤 8 · 总收率 2.5g(Pantoprazole (Free))
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| S-pantoprazole sodium-010 | 103-90-2 | 4-Acetamidophenol |
| S-pantoprazole sodium-011 | 75-45-6 | Chlorodifluoromethane |
| S-pantoprazole sodium-012 | 22236-11-9 | N-[4-(Difluoromethoxy)phenyl]acetamide |
| S-pantoprazole sodium-013 | 97963-75-2 | N-[4-(Difluoromethoxy)-2-nitrophenyl]acetamide |
| S-pantoprazole sodium-014 | 72830-09-2 | 2-(Chloromethyl)-3,4-dimethoxypyridine hydrogen chloride |
| S-pantoprazole sodium-015 | 97963-76-3 | 4-(Difluoromethoxy)-2-nitroaniline |
| S-pantoprazole sodium-002 | 172282-50-7 | 1,2-Diamino-4-(difluoromethoxy)benzene |
| S-pantoprazole sodium-016 | 140-89-6 | O-Ethylxanthic acid potassium salt |
| S-pantoprazole sodium-017 | 97963-62-7 | 5-(Difluoromethoxy)-1H-benzimidazole-2-thiol |
| S-pantoprazole sodium-018 | 102625-64-9 | 5-(Difluoromethoxy)-2-(3,4-dimethoxypyridin-2-ylmethylsulfanyl)-1H-benzimidazole |
| S-pantoprazole sodium-019 | 72830-08-1 | (3,4-Dimethoxypyridin-2-yl)methanol |
优化Route 4步骤 10 · 总收率 /
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| S-pantoprazole sodium-019 | 72830-08-1 | (3,4-Dimethoxypyridin-2-yl)methanol |
| S-pantoprazole sodium-021 | 1121-25-1 | 2-Methylpyridin-3-ol |
| S-pantoprazole sodium-022 | 26395-26-6 | 3-methoxy-2-methylpyridine |
| S-pantoprazole sodium-023 | 35392-65-5 | 3-methoxy-2-methyl-1-oxidopyridin-1-ium |
| S-pantoprazole sodium-024 | 15931-25-6 | 3-methoxy-2-methyl-4-nitro-1-oxido-1-pyridin-1-ylium |
| S-pantoprazole sodium-025 | 72830-07-0 | 3,4-Dimethoxy-2-methylpyridine 1-oxide |
| S-pantoprazole sodium-026 | 108-24-7 | Acetic anhydride |
| S-pantoprazole sodium-027 | 102625-99-0 | (3,4-dimethoxypyridin-2-yl)methyl acetate |
| S-pantoprazole sodium-020 | 7295-76-3 | 3-methoxypyridine |
| S-pantoprazole sodium-028 | 1956319-26-8 | 4-Chloro-3-methoxypyridine hydrochloride |
| S-pantoprazole sodium-029 | 617-35-6 | 2-Oxopropionic acid ethyl ester |
| S-pantoprazole sodium-030 | 1261741-83-6 | ethyl 4-chloro-3-methoxypyridine-2-carboxylate |
| S-pantoprazole sodium-031 | - | methyl 3,4-dimethoxypyridine-2-carboxylate |
优化Route 5步骤 12 · 总收率 61.88g(Pantoprazole (Free))
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| S-pantoprazole sodium-004 | 169905-10-6 | 2-(chloromethyl)-3,4-dimethoxypyridine |
| S-pantoprazole sodium-032 | 854278-84-5 | 2-(3,4-dimethoxypyridin-2-yl)acetonitrile |
| S-pantoprazole sodium-033 | 854278-85-6 | methyl 2-(3,4-dimethoxypyridin-2-yl)acetate |
| S-pantoprazole sodium-034 | 854278-86-7 | methyl 2-bromo-2-(3,4-dimethoxypyridin-2-yl)acetate |
| S-pantoprazole sodium-036 | 1182314-64-2 | 5-(difluoromethyl)-1H-benzimidazole-2-thiol |
| S-pantoprazole sodium-037 | - | methyl 2-{[5-(difluoromethyl)-1H-benzimidazol-2-yl]sulfanyl}-2-(3,4-dimethoxypyridin-2-yl)acetate |
| S-pantoprazole sodium-038 | - | 2-{[5-(difluoromethyl)-1H-benzimidazol-2-yl]sulfanyl}-2-(3,4-dimethoxypyridin-2-yl)acetamide |
| S-pantoprazole sodium-039 | - | 2-[5-(difluoromethyl)-1H-benzimidazole-2-sulfinyl]-2-(3,4-dimethoxypyridin-2-yl)acetamide |
| S-pantoprazole sodium-035 | 854278-90-3 | 2-(3,4-dimethoxypyridin-2-yl)acetamide |
| S-pantoprazole sodium-040 | 854278-91-4 | 2-bromo-2-(3,4-dimethoxypyridin-2-yl)acetamide |
| S-pantoprazole sodium-041 | - | 5-(difluoromethyl)-2-{[(3,4-dimethoxypyridin-2-yl)methyl]sulfanyl}-1H-benzimidazole |
优化Route 6步骤 3 · 总收率 159g((S)-(-)-Pantoprazole sodium (API))
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| S-pantoprazole sodium-043 | 368890-20-4 | 2-[[(4-Chloro-3-methoxypyridin-2-yl)methyl]sulfanyl]-5-(difluoromethoxy)-1H-benzimidazole |
| S-pantoprazole sodium-044 | 409098-86-8 | 2-[[(4-Chloro-3-methoxypyridin-2-yl)methane]sulfinyl]-5-(difluoromethoxy)-1H-benzimidazole |
| S-pantoprazole sodium-045 | 102625-70-7 | 5-(Difluoromethoxy)-2-(3,4-dimethoxypyridin-2-ylmethylsulfinyl)-1H-benzimidazole |
优化Route 7步骤 11 · 总收率 5.2g((S)-(-)-Pantoprazole sodium (API))
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| S-pantoprazole sodium-046 | 118-71-8 | 3-Hydroxy-2-methyl-4H-pyran-4-one |
| S-pantoprazole sodium-047 | 4780-14-7 | 3-Methoxy-2-methyl-4H-pyran-4-one |
| S-pantoprazole sodium-048 | 76015-11-7 | 3-Methoxy-2-methylpyridin-4-one |
| S-pantoprazole sodium-049 | 107512-34-5 | 4-Chloro-3-methoxy-2-methylpyridine |
| S-pantoprazole sodium-050 | 97963-62-7 | 5-(Difluoromethoxy)-1H-benzimidazole-2-thiol |
| S-pantoprazole sodium-025 | 122307-41-9 | 4-Chloro-3-methoxy-2-methylpyridine 1-oxide |
| S-pantoprazole sodium-019 | 72830-07-0 | 3,4-Dimethoxy-2-methylpyridine 1-oxide |
| S-pantoprazole sodium-014 | 72830-08-1 | (3,4-Dimethoxypyridin-2-yl)methanol |
| S-pantoprazole sodium-017 | 72830-09-2 | 2-(Chloromethyl)-3,4-dimethoxypyridine hydrogen chloride |
| S-pantoprazole sodium-018 | 102625-64-9 | 5-(Difluoromethoxy)-2-(3,4-dimethoxypyridin-2-ylmethylsulfanyl)-1H-benzimidazole |
| S-pantoprazole sodium-045 | 102625-70-7 | 5-(Difluoromethoxy)-2-(3,4-dimethoxypyridin-2-ylmethylsulfinyl)-1H-benzimidazole |
优化Route 8步骤 3 · 总收率 25g(S-pantoprazole sodium-025)
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| S-pantoprazole sodium-046 | 118-71-8 | 3-Hydroxy-2-methyl-4H-pyran-4-one |
| S-pantoprazole sodium-025 | 72830-07-0 | 3,4-Dimethoxy-2-methylpyridine 1-oxide |
| S-pantoprazole sodium-051 | - | 3-Hydroxy-2-methylpyridin-4(1H)-one |
| S-pantoprazole sodium-052 | 107512-35-6 | 3,4-Dimethoxy-2-methylpyridine |
优化Route 9步骤 2 · 总收率 209g((S)-(-)-Pantoprazole sodium (API))
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| S-pantoprazole sodium-018 | 102625-64-9 | 5-(Difluoromethoxy)-2-(3,4-dimethoxypyridin-2-ylmethylsulfanyl)-1H-benzimidazole |
| S-pantoprazole sodium-045 | 102625-70-7 | 5-(Difluoromethoxy)-2-(3,4-dimethoxypyridin-2-ylmethylsulfinyl)-1H-benzimidazole |
优化Route 10步骤 6 · 总收率 /
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| S-pantoprazole sodium-010 | 103-90-2 | 4-Acetamidophenol |
| S-pantoprazole sodium-011 | 75-45-6 | Chlorodifluoromethane |
| S-pantoprazole sodium-012 | 22236-11-9 | N-[4-(Difluoromethoxy)phenyl]acetamide |
| S-pantoprazole sodium-013 | 97963-75-2 | N-[4-(Difluoromethoxy)-2-nitrophenyl]acetamide |
| S-pantoprazole sodium-053 | 780782-96-9 | N-[2-Amino-4-(difluoromethoxy)phenyl]acetamide |
| S-pantoprazole sodium-017 | 97963-62-7 | 5-(Difluoromethoxy)-1H-benzimidazole-2-thiol |
| S-pantoprazole sodium-014 | 72830-09-2 | 2-(Chloromethyl)-3,4-dimethoxypyridine hydrogen chloride |
| S-pantoprazole sodium-018 | 102625-64-9 | 5-(Difluoromethoxy)-2-(3,4-dimethoxypyridin-2-ylmethylsulfanyl)-1H-benzimidazole |
优化Route 11步骤 1 · 总收率 /
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| S-pantoprazole sodium-018 | 102625-64-9 | 5-(Difluoromethoxy)-2-(3,4-dimethoxypyridin-2-ylmethylsulfanyl)-1H-benzimidazole |
| S-pantoprazole sodium-054 | 142706-18-1 | (+)-5-(Difluoromethoxy)-2-[(R)-[(3,4-dimethoxypyridin-2-yl)methyl]sulfinyl]-1H-benzimidazole |
优化Route 12步骤 4 · 总收率 7g(Pantoprazole (Free))
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| S-pantoprazole sodium-014 | 72830-09-2 | 2-(Chloromethyl)-3,4-dimethoxypyridine hydrogen chloride |
| S-pantoprazole sodium-055 | 62-56-6在售 | Aminothiocarboxamide |
| S-pantoprazole sodium-056 | 179116-74-6 | (3,4-Dimethoxypyridin-2-yl)methyl hydrosulfide |
| S-pantoprazole sodium-057 | 541-41-3 | Chloridocarbonic acid ethyl ester |
| S-pantoprazole sodium-058 | - | Ethyl (3,4-dimethoxy-2-pyridyl)methylsulfanylformate |
| S-pantoprazole sodium-002 | 172282-50-7 | 1,2-Diamino-4-(difluoromethoxy)benzene |
| S-pantoprazole sodium-018 | 102625-64-9 | 5-(Difluoromethoxy)-2-(3,4-dimethoxypyridin-2-ylmethylsulfanyl)-1H-benzimidazole |
| S-pantoprazole sodium-045 | 102625-70-7 | 5-(Difluoromethoxy)-2-(3,4-dimethoxypyridin-2-ylmethylsulfinyl)-1H-benzimidazole |
优化Route 13步骤 3 · 总收率 2.83g(Pantoprazole (Free))
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| S-pantoprazole sodium-015 | 97963-76-3 | 4-(Difluoromethoxy)-2-nitroaniline |
| S-pantoprazole sodium-002 | 172282-50-7 | 1,2-Diamino-4-(difluoromethoxy)benzene |
| S-pantoprazole sodium-059 | 75-15-0 | Carbon disulfide |
| S-pantoprazole sodium-017 | 97963-62-7 | 5-(Difluoromethoxy)-1H-benzimidazole-2-thiol |
| S-pantoprazole sodium-014 | 72830-09-2 | 2-(Chloromethyl)-3,4-dimethoxypyridine hydrogen chloride |
| S-pantoprazole sodium-004 | 169905-10-6 | 2-(chloromethyl)-3,4-dimethoxypyridine |
| S-pantoprazole sodium-018 | 102625-64-9 | 5-(Difluoromethoxy)-2-(3,4-dimethoxypyridin-2-ylmethylsulfanyl)-1H-benzimidazole |
| S-pantoprazole sodium-060 | 953787-47-8 | 2-(Chloromethyl)-3,4-dimethoxy-1-oxo-1lambda5-pyridine |
| S-pantoprazole sodium-061 | 953787-51-4 | - |
优化Route 14步骤 6 · 总收率 65g(Pantoprazole (Free))
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| S-pantoprazole sodium-024 | 15931-25-6 | 3-methoxy-2-methyl-4-nitro-1-oxido-1-pyridin-1-ylium |
| S-pantoprazole sodium-062 | 368890-16-8 | (3-methoxy-4-nitropyridin-2-yl)methyl methanesulfonate |
| S-pantoprazole sodium-017 | 97963-62-7 | 5-(Difluoromethoxy)-1H-benzimidazole-2-thiol |
| S-pantoprazole sodium-018 | 102625-64-9 | 5-(Difluoromethoxy)-2-(3,4-dimethoxypyridin-2-ylmethylsulfanyl)-1H-benzimidazole |
| S-pantoprazole sodium-050 | 122307-41-9 | 4-Chloro-3-methoxy-2-methylpyridine 1-oxide |
| S-pantoprazole sodium-063 | 368890-18-0 | (4-chloro-3-methoxypyridin-2-yl)methyl methanesulfonate |
| S-pantoprazole sodium-043 | 368890-20-4 | 2-[[(4-Chloro-3-methoxypyridin-2-yl)methyl]sulfanyl]-5-(difluoromethoxy)-1H-benzimidazole |
优化Route 15步骤 1 · 总收率 /
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| S-pantoprazole sodium-018 | 102625-64-9 | 5-(Difluoromethoxy)-2-(3,4-dimethoxypyridin-2-ylmethylsulfanyl)-1H-benzimidazole |
优化Route 17步骤 5 · 总收率 54.1g((S)-(-)-Pantoprazole sodium (API))
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| S-pantoprazole sodium-018 | 102625-64-9 | 5-(Difluoromethoxy)-2-(3,4-dimethoxypyridin-2-ylmethylsulfanyl)-1H-benzimidazole |
| S-pantoprazole sodium-045 | 102625-70-7 | 5-(Difluoromethoxy)-2-(3,4-dimethoxypyridin-2-ylmethylsulfinyl)-1H-benzimidazole |
| S-pantoprazole sodium-065 | - | 1-[5-(Difluoromethoxy)-2-[(3,4-dimethoxypyridin-2-yl)methanesulfinyl]-1H-benzimidazol-1-yl]ethan-1-one |
| S-pantoprazole sodium-066 | - | 1-[5-(Difluoromethoxy)-2-[(S)-(3,4-dimethoxypyridin-2-yl)methanesulfinyl]-1H-benzimidazol-1-yl]ethan-1-one |
| S-pantoprazole sodium-064 | 142678-35-1 | (-)-(S)-Pantoprazole |
工艺Route 16步骤 7 · 总收率 1.1kg((S)-(-)-Pantoprazole sodium (API))
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| S-pantoprazole sodium-014 | 72830-09-2 | 2-(Chloromethyl)-3,4-dimethoxypyridine hydrogen chloride |
| S-pantoprazole sodium-017 | 97963-62-7 | 5-(Difluoromethoxy)-1H-benzimidazole-2-thiol |
| S-pantoprazole sodium-018 | 102625-64-9 | 5-(Difluoromethoxy)-2-(3,4-dimethoxypyridin-2-ylmethylsulfanyl)-1H-benzimidazole |
| S-pantoprazole sodium-064 | 142678-35-1 | (-)-(S)-Pantoprazole |
常见问题（FAQ）
（S）-泮托拉唑钠的适应症有哪些？
已批准的适应症包括：胃食管反流病、消化性溃疡。
（S）-泮托拉唑钠的专利什么时候到期？
（S）-泮托拉唑钠的专利到期年暂无公开口径，本页会在数据管道核实后更新。
（S）-泮托拉唑钠有几条合成路线？
本站收录 17 条合成路线，最短路线 1 步、总收率 /。每条路线的中间体均带登记编号与 CAS 号。
（S）-泮托拉唑钠的关键中间体在哪里可以采购？
（S）-泮托拉唑钠的多条路线中间体已挂接 CAS 档案，其中 1 个 CAS 已有优贝德（Unibest）供应网络在售报价，可在本页路线表中直接查看并询价。
如何获取（S）-泮托拉唑钠中间体的报价？
在本页选择目标中间体的 CAS 进入档案页，或在询价页直接提交需求；CAS 会自动带入供需撮合流程，由供应网络反馈报价。
数据来源：多源数据交叉核实（仅结构化字段） · 2026-09-24