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CAS 541-41-3
Carbonochloridic acid ethyl esterethyl carbonochloridateChloridocarbonic acid ethyl ester
登记编号：(II)461018-4-a、SIME-015、IVAC-011、AZILS-006、S-pantoprazole sodium-057
应用背景（按来源药适应症）
华氏巨球蛋白血症伊布替尼慢性淋巴细胞白血病伊布替尼套细胞淋巴瘤伊布替尼移植物抗宿主病伊布替尼丙型肝炎西美瑞韦钠慢性丙型肝炎西美瑞韦钠麻疹西美瑞韦钠结核分枝杆菌感染西美瑞韦钠囊性纤维化艾伐卡托慢性支气管炎艾伐卡托慢性阻塞性肺疾病艾伐卡托鼻窦炎艾伐卡托高血压阿齐沙坦原发性高血压阿齐沙坦二型糖尿病阿齐沙坦肥胖症阿齐沙坦糖尿病阿齐沙坦胃食管反流病（S）-泮托拉唑钠消化性溃疡（S）-泮托拉唑钠出血（S）-泮托拉唑钠创伤和损伤（S）-泮托拉唑钠昏迷（S）-泮托拉唑钠吸入性肺炎（S）-泮托拉唑钠
来源药（使用该中间体的合成路线）
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
4-(Phenyloxy)benzoic acid→Carbonochloridic acid ethyl ester→Ethyl 4-phenoxybenzoyl carbonate→1,1-Dicyanomethane→3-(4-Phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine→(4-Phenoxybenzoyl)malononitrile→[Chloro(4-phenoxyphenyl)methylene]malononitrile→3-Amino-4-cyano-5-(4-phenoxyphenyl)pyrazole→Formamidine acetate→3-Chloro-1H-pyrazolo[3,4-d]pyrimidin-4-amine→3-Bromo-1H-pyrazolo[3,4-d]pyrimidin-4-amine→3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine→4-Amino-1H-pyrazolo[3,4-d]pyrimidin-3-ylmethanesulfonate
N-methylhex-5-en-1-amine→2-(4-isopropylthiazol-2-yl)-7-methoxy-8-methylquinolin-4-ol→(1R,2S)-ethyl 1-((1R,2R,4R)-2-(hex-5-en-1-yl(methyl)carbamoyl)-4-((2-(4-isopropylthiazol-2-yl)-7-methoxy-8-methylquinolin-4-yl)oxy)cyclopentanecarboxamido)-2-vinylcyclopropanecarboxylate→tetraethyl butane-1,2,3,4-tetracarboxylate→4-oxocyclopentane-1,2-dicarboxylic acid→4-hydroxycyclopentane-1,2-dicarboxylic acid→4-hydroxycyclopentane-1,2-dicarboxylic acid→ethyl carbonochloridate→3-oxo-2-oxabicyclo[2.2.1]heptane-5-carboxylic acid→(1S,4R,5R)-benzyl 3-oxo-2-oxabicyclo[2.2.1]heptane-5-carboxylate→butane-1,2,3,4-tetracarboxylic acid→(1R,2R,4R)-1-benzyl 2-methyl 4-((2-(4-isopropylthiazol-2-yl)-7-methoxy-8-methylquinolin-4-yl)oxy)cyclopentane-1,2-dicarboxylate→(1R,2R,4S)-4-((2-(4-isopropylthiazol-2-yl)-7-methoxy-8-methylquinolin-4-yl)oxy)-2-(methoxycarbonyl)cyclopentanecarboxylic acid→(1R,2R,4S)-methyl 2-(hex-5-en-1-yl(methyl)carbamoyl)-4-((2-(4-isopropylthiazol-2-yl)-7-methoxy-8-methylquinolin-4-yl)oxy)cyclopentanecarboxylate→lithium (1R,2R,4S)-2-(hex-5-en-1-yl(methyl)carbamoyl)-4-((2-(4-isopropylthiazol-2-yl)-7-methoxy-8-methylquinolin-4-yl)oxy)cyclopentanecarboxylate→(1R,2S)-ethyl 1-amino-2-vinylcyclopropanecarboxylate
2,4-di-tert-butylphenol→ethyl carbonochloridate→2,4-di-tert-butylphenyl ethyl carbonate→2,4-di-tert-butyl-5-nitrophenyl ethyl carbonate→5-amino-2,4-di-tert-butylphenyl ethyl carbonate→4-oxo-1,4-dihydroquinoline-3-carbonyl chloride→2,4-di-tert-butyl-5-(4-oxo-1,4-dihydroquinoline-3-carboxamido)phenyl ethyl carbonate
methyl 2-(((2'-cyano-[1,1'-biphenyl]-4-yl)methyl)amino)-3-nitrobenzoate→methyl 3-amino-2-(((2'-cyano-[1,1'-biphenyl]-4-yl)methyl)amino)benzoate→triethoxymethoxyethane→methyl 1-((2'-cyano-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate→methyl (Z)-2-ethoxy-1-((2'-(N'-hydroxycarbamimidoyl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate→ethyl carbonochloridate→methyl (Z)-2-ethoxy-1-((2'-(N'-((ethoxycarbonyl)oxy)carbamimidoyl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate→methyl 2-ethoxy-1-((2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate
2-(Chloromethyl)-3,4-dimethoxypyridine hydrogen chloride→Aminothiocarboxamide→(3,4-Dimethoxypyridin-2-yl)methyl hydrosulfide→Chloridocarbonic acid ethyl ester→Ethyl (3,4-dimethoxy-2-pyridyl)methylsulfanylformate→1,2-Diamino-4-(difluoromethoxy)benzene→5-(Difluoromethoxy)-2-(3,4-dimethoxypyridin-2-ylmethylsulfanyl)-1H-benzimidazole→5-(Difluoromethoxy)-2-(3,4-dimethoxypyridin-2-ylmethylsulfinyl)-1H-benzimidazole
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