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CAS 138421-23-5
Acetone O-isobutyryloxime
登记编号：Molnupiravir-010
应用背景（按来源药适应症）
新型冠状病毒感染莫诺拉韦呼吸道合胞体病毒感染莫诺拉韦流感病毒感染莫诺拉韦肾功能不全莫诺拉韦肝功能衰退莫诺拉韦
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| 莫诺拉韦Molnupiravir | Tier B · 提前布局 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
1-(beta-D-Ribofuranosyl)uracil→1-[(3aR,4R,6R,6aR)-6-(Hydroxymethyl)-2,2-dimethyl-tetrahydro-2H-furo[3,4-d][1,3]dioxol-4-yl]-1,2,3,4-tetrahydropyrimidine-2,4-dione<-fgf->2',3'-O-Isopropylideneuridine→2-Methylpropionic anhydride→2',3'-O-(1-Methylethylidene)-5'-O-(2-methylpropanoyl)uridine→N-Hydroxy-2',3'-O-(1-methylethylidene)-5'-O-(2-methylpropanoyl)cytidine→1H-1,2,4-Triazole→1-[2,3-O-(1-Methylethylidene)-5-O-(2-methylpropanoyl)-beta-D-ribofuranosyl]-4-(1H-1,2,4-triazol-1-yl)pyrimidin-2(1H)-one→1-beta-D-Ribofuranosyl-4-(1H-1,2,4-triazol-1-yl)-3,4-dihydropyrimidin-2(1H)-one→1-[2,3-O-(1-Methylethylidene)-beta-D-ribofuranosyl]-4-(1H-1,2,4-triazol-1-yl)pyrimidin-2(1H)-one→Acetone O-isobutyryloxime→1-[(2xi)-5-O-(2-Methylpropanoyl)-beta-D-erythro-pentofuranosyl]-4-(1H-1,2,4-triazol-1-yl)-3,4-dihydropyrimidin-2(1H)-one
Acetone oxime→2',3'-O-(1-Methylethylidene)-5'-O-(2-methylpropanoyl)cytidine→5'-O-Isobutyryl cytidine→Acetone→2-Methylpropionic acid→Sulfuric acid 2',3'-O-(1-methylethylidene)cytidine→Isobutyric anhydride→1-(beta-D-Ribofuranosyl)cytosine→Acetone O-isobutyryloxime→N-Hydroxy-2',3'-O-(1-methylethylidene)-5'-O-(2-methylpropanoyl)cytidine
Acetone O-isobutyryloxime→2-Methylpropionyl chloride→2-Methylpropionic acid→2-Propanone→N-Hydroxypropan-2-imine
N-Hydroxy-2',3'-O-(1-methylethylidene)cytidine→2,2,2-Trifluoroethyl 2-methylpropanoate→1-[(3aR,4R,6R,6aR)-6-(Hydroxymethyl)-2,2-dimethyl-tetrahydro-2H-furo[3,4-d][1,3]dioxol-4-yl]-1,2,3,4-tetrahydropyrimidine-2,4-dione<-fgf->2',3'-O-Isopropylideneuridine→Hydroxylammonium chloride→Acetone O-isobutyryloxime→Ethenyl 2-methylpropanoate→N-Hydroxy-2',3'-O-(1-methylethylidene)-5'-O-(2-methylpropanoyl)cytidine→2',3'-O-(1-Methylethylidene)-5'-O-(2-methylpropanoyl)uridine
N-[(Dimethylamino)methylidene]cytidine→5'-O-(2-Methylpropanoyl)cytidine oxalate→N,O2',O3'-Tris[(dimethylamino)methylidene]cytidine→1-(beta-D-Ribofuranosyl)cytosine→Acetone O-isobutyryloxime→Isobutyryl chloride→2-Methylpropionic acid→5'-O-Isobutyryl cytidine→Dimethylacetic anhydride
本站可供应的对应中间体
同 CAS 多家在售供应横向对比；价格区间为供应方挂牌口径，实价以询价确认为准。
| 供应商 | 产品 | 价格区间 | 最小起订 | 货期 | 资质 | 操作 |
|---|---|---|---|---|---|---|
| Unibest Taizhou GMP-like Site | ((3aR,4R,6R,6aR)-6-(4-(hydroxyamino)-2-oxopyrimidin-1(2H)-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl isobutyrate Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
本页为中间体 CAS 注册档案：同 CAS 的多条路线登记已合并；后续供应商报价与买方需求以该 CAS 为主键撮合。