CAS 65-46-3

Cytosine-1-beta-D-ribofuranoside1-(beta-D-Ribofuranosyl)cytosineCytosine beta-D-riboside1-(beta-D-Ribofuranosyl)cytosine<-fgf->

登记编号：Molnupiravir-019

应用背景（按来源药适应症）

新型冠状病毒感染莫诺拉韦呼吸道合胞体病毒感染莫诺拉韦流感病毒感染莫诺拉韦肾功能不全莫诺拉韦肝功能衰退莫诺拉韦

来源药（使用该中间体的合成路线）

品种	梯队	到期年
莫诺拉韦Molnupiravir	Tier B · 提前布局	-

合成路线中的位置（上下游链）

按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。

莫诺拉韦优化路线步数：12总收率：/

Molnupiravir-012→Methyl 2,3-O-isopropylidene-beta-D-ribofuranoside→Methyl 5-O-benzoyl-2,3-O-(1-methylethylidene)-beta-D-ribofuranoside→1,2,3-Tri-O-acetyl-5-O-benzoyl-beta-D-ribofuranose→2-Methylpropionyl chloride→N-(2-Oxo-1,2-dihydropyrimidin-4-yl)acetamide→N-Acetyl-2',3'-di-O-acetyl-5'-O-benzoylcytidine→Cytosine-1-beta-D-ribofuranoside→Sulfuric acid 2',3'-O-(1-methylethylidene)cytidine→2',3'-O-(1-Methylethylidene)cytidine→2',3'-O-(1-Methylethylidene)-N-(2-methylpropanoyl)-5'-O-(2-methylpropanoyl)cytidine→Hydroxylamine→Hydroxylamine hydrochloride→Hydroxylamine sulfate→N-Hydroxy-2',3'-O-(1-methylethylidene)-5'-O-(2-methylpropanoyl)cytidine→2-Methylpropionic anhydride

莫诺拉韦优化路线步数：11总收率：/

Acetone oxime→2',3'-O-(1-Methylethylidene)-5'-O-(2-methylpropanoyl)cytidine→5'-O-Isobutyryl cytidine→Acetone→2-Methylpropionic acid→Sulfuric acid 2',3'-O-(1-methylethylidene)cytidine→Isobutyric anhydride→1-(beta-D-Ribofuranosyl)cytosine→Acetone O-isobutyryloxime→N-Hydroxy-2',3'-O-(1-methylethylidene)-5'-O-(2-methylpropanoyl)cytidine

莫诺拉韦优化路线步数：8总收率：77.1g(Molnupiravir)

N4-Hydroxycytidine→2-Methylpropyl 2-methylpropanoate→Ethenyl 2-methylpropanoate→1-(beta-D-Ribofuranosyl)cytosine→Acetone O-isobutyryloxime→2-Methylpropionyl chloride→5'-O-Isobutyryl cytidine→2-Methylpropionic anhydride

莫诺拉韦优化路线步数：1总收率：76g(Molnupiravir-043)

Methanesulfonic acid 2',3'-O-(1-methylethylidene)cytidine (1/1)→Cytosine-1-beta-D-ribofuranoside

莫诺拉韦优化路线步数：6总收率：5.14g(Molnupiravir)

N-[(Dimethylamino)methylidene]cytidine→5'-O-(2-Methylpropanoyl)cytidine oxalate→N,O2',O3'-Tris[(dimethylamino)methylidene]cytidine→1-(beta-D-Ribofuranosyl)cytosine→Acetone O-isobutyryloxime→Isobutyryl chloride→2-Methylpropionic acid→5'-O-Isobutyryl cytidine→Dimethylacetic anhydride

莫诺拉韦优化路线步数：7总收率：343mg(Molnupiravir)

N-[(Dimethylamino)methylidene]-2',3'-O-[(dimethylamino)methylidene]-5'-O-(2-methylpropanoyl)cytidine→N-[(Dimethylamino)methylidene]-5'-O-(2-methylpropanoyl)cytidine→N-[(Hydroxyimino)methyl]-5'-O-(2-methylpropanoyl)cytidine→Cytosine beta-D-riboside→N,O2',O3'-Tris[(dimethylamino)methylidene]cytidine→Dimethylacetic anhydride

莫诺拉韦优化路线步数：4总收率：42.9g(Molnupiravir)

2',3'-O-[(Dimethylamino)methylidene]-N-hydroxycytidine→2',3'-O-[(Dimethylamino)methylidene]-N-hydroxy-5'-O-(2-methylpropanoyl)cytidine→Cytosine-1-beta-D-ribofuranoside→N4-Hydroxycytidine→Isobutyric anhydride

莫诺拉韦优化路线步数：4总收率：/

Sulfuric acid 2',3'-O-benzylidenecytidine (1/1)→Sulfuric acid 2',3'-O-methylidenecytidine (1/1)→2',3'-O-Benzylidene-5'-O-(2-methylpropanoyl)cytidine→2',3'-O-Methylidene-5'-O-(2-methylpropanoyl)cytidine→2',3'-O-Benzylidene-N-hydroxy-5'-O-(2-methylpropanoyl)cytidine→N-Hydroxy-2',3'-O-methylidene-5'-O-(2-methylpropanoyl)cytidine→1-(beta-D-Ribofuranosyl)cytosine→2-Methylpropionic anhydride→Hydroxylamine sulfate

莫诺拉韦优化路线步数：6总收率：85mg(Molnupiravir)

1-(beta-D-Ribofuranosyl)cytosine<-fgf->→N4-Hydroxycytidine→Isobutyric anhydride→5'-O-(2-Methylpropanoyl)-N-[(2-methylpropanoyl)oxy]cytidine→N-[(2-Methylpropanoyl)oxy]cytidine

本站可供应的对应中间体

同 CAS 多家在售供应横向对比；价格区间为供应方挂牌口径，实价以询价确认为准。

供应商	产品	价格区间	最小起订	货期	资质	操作
Unibest Taizhou GMP-like Site	((3aR,4R,6R,6aR)-6-(4-(hydroxyamino)-2-oxopyrimidin-1(2H)-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl isobutyrate Pharmaceutical Intermediates	询价	询价	询价	—

本页为中间体 CAS 注册档案：同 CAS 的多条路线登记已合并；后续供应商报价与买方需求以该 CAS 为主键撮合。