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CAS 141-97-9
ethyl 3-oxobutanoate1-Ethoxybutane-1,3-dione
登记编号：PALB-027、(XXXVI)1024528-1-d、SITAF-014、SUNT-012
应用背景（按来源药适应症）
乳腺癌哌柏西利非小细胞肺癌普拉替尼甲状腺瘤普拉替尼甲状腺髓样癌普拉替尼膀胱炎西他沙星鼻窦炎西他沙星扁桃体炎西他沙星肺炎西他沙星宫颈炎西他沙星冠周炎西他沙星胰腺神经内分泌肿瘤苹果酸舒尼替尼肾细胞癌苹果酸舒尼替尼胃肠道间质瘤苹果酸舒尼替尼骨肉瘤苹果酸舒尼替尼肉瘤苹果酸舒尼替尼淋巴瘤苹果酸舒尼替尼
来源药（使用该中间体的合成路线）
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
cyclopentanamine→tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate→ethyl 3-oxobutanoate→N-cyclopentyl-3-oxo-N-(3-oxobutanoyl)butanamide→3-acetyl-1-cyclopentyl-6-hydroxy-4-methylpyridin-2(1H)-one→5-acetyl-2-chloro-1-cyclopentyl-4-methyl-6-oxo-1,6-dihydropyridine-3-carbaldehyde→tert-butyl 4-(6-guanidinopyridin-3-yl)piperazine-1-carboxylate sulfate→methyl carbamimidothioate sulfate
1,4 Cyclohexanedione ethylene ketal→Methyl 1-methoxy-4-(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)cyclohexane-1-carboxylate→1,4-Dioxaspiro[4.5]decane-8-carbonitrile→N-Hydroxy-1,4-dioxaspiro[4.5]decane-8-carboximidamide→1,4-Dioxaspiro[4.5]decane-8-carboximidamide→1-Ethoxybutane-1,3-dione→2-(1,4-Dioxaspiro[4.5]decan-8-yl)-6-methylpyrimidin-4-ol→4-(4-Hydroxy-6-methylpyrimidin-2-yl)cyclohexan-1-one
ethyl 3-(3-chloro-2,4,5-trifluorophenyl)-3-oxopropanoate→(Z)-ethyl 2-(3-chloro-2,4,5-trifluorobenzoyl)-3-ethoxyacrylate→tert-butyl ((1R,2S)-2-fluorocyclopropyl)carbamate→ethyl (Z)-2-(3-chloro-2,4,5-trifluorobenzoyl)-3-(((1R,2S)-2-fluorocyclopropyl)amino)acrylate→ethyl 8-chloro-6,7-difluoro-1-((1R,2S)-2-fluorocyclopropyl)-4-oxo-1,4-dihydroquinoline-3-carboxylate→8-chloro-6,7-difluoro-1-((1R,2S)-2-fluorocyclopropyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid→SITAF-007→7-((S)-7-((tert-butoxycarbonyl)amino)-5-azaspiro[2.4]heptan-5-yl)-8-chloro-6-fluoro-1-((1R,2S)-2-fluorocyclopropyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid→2-fluorocyclopropane-1-carboxylic acid→(R)-1-phenylethan-1-amine→2-fluoro-N-((R)-1-phenylethyl)cyclopropane-1-carboxamide→2-fluoro-N-((R)-1-phenylethyl)cyclopropane-1-carboxamide→(1S,2S)-2-fluoro-N-((R)-1-phenylethyl)cyclopropane-1-carboxamide→ethyl 3-oxobutanoate→1,2-dibromoethane→ethyl 1-acetylcyclopropane-1-carboxylate→ethyl 1-(2-bromoacetyl)cyclopropane-1-carboxylate→(R)-5-(1-phenylethyl)-5-azaspiro[2.4]heptane-4,7-dione→(R,Z)-7-(hydroxyimino)-5-(1-phenylethyl)-5-azaspiro[2.4]heptan-4-one→(S)-7-amino-5-((R)-1-phenylethyl)-5-azaspiro[2.4]heptan-4-one→(S)-5-((R)-1-phenylethyl)-5-azaspiro[2.4]heptan-7-amine→tert-butyl ((S)-5-((R)-1-phenylethyl)-5-azaspiro[2.4]heptan-7-yl)carbamate
N1,N1-diethylethane-1,2-diamine→tert-butyl 3-oxobutanoate→N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide→5-fluoroindolin-2-one→(S)-2-hydroxysuccinic acid→(E)-tert-butyl 2-(hydroxyimino)-3-oxobutanoate→ethyl 3-oxobutanoate→2-(tert-butyl) 4-ethyl 3,5-dimethyl-1H-pyrrole-2,4-dicarboxylate→ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate→ethyl 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylate→5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid
N1,N1-diethylethane-1,2-diamine→N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide→ethyl 3-oxobutanoate→ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate→ethyl 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylate→5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid→diethyl 3,5-dimethyl-1H-pyrrole-2,4-dicarboxylate→4-(ethoxycarbonyl)-3,5-dimethyl-1H-pyrrole-2-carboxylic acid→diethyl (2-((4-fluoro-2-iodophenyl)amino)-2-oxoethyl)phosphonate→(Z)-N-(2-(diethylamino)ethyl)-5-(3-((4-fluoro-2-iodophenyl)amino)-3-oxoprop-1-en-1-yl)-2,4-dimethyl-1H-pyrrole-3-carboxamide→4-fluoro-2-iodoaniline→2-chloroacetyl chloride→2-chloro-N-(4-fluoro-2-iodophenyl)acetamide→triethyl phosphite
N1,N1-diethylethane-1,2-diamine→5-fluoroindolin-2-one→(S)-2-hydroxysuccinic acid→ethyl 3-oxobutanoate→ethyl 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylate→diethyl 3,5-dimethyl-1H-pyrrole-2,4-dicarboxylate→4-(ethoxycarbonyl)-3,5-dimethyl-1H-pyrrole-2-carboxylic acid→ethyl (Z)-5-((5-fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxylate
本站可供应的对应中间体
同 CAS 多家在售供应横向对比；价格区间为供应方挂牌口径，实价以询价确认为准。
| 供应商 | 产品 | 价格区间 | 最小起订 | 货期 | 资质 |
|---|---|---|---|---|---|
| Qualified Partner — East China API Works | 5-broMo-2-chloro-N-cyclopentylpyriMidin-4-aMine Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Unibest Nantong cGMP Site | 2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Unibest Taizhou GMP-like Site | 6-broMo-2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Qualified Partner — East China API Works | tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Unibest Nantong cGMP Site | Tert-butyl 4-(6-nitropyridin-3-yl)piperazine-1-carboxylate Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Unibest Taizhou GMP-like Site | tert-Butyl 4-(6-((6-(1-butoxyvinyl)-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Qualified Partner — East China API Works | PD 0332991 HCl Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Unibest Nantong cGMP Site | Carbamic acid, (7S)-5-azaspiro[2.4]hept-7-yl-, 1,1-dimethylethyl ester (9CI) Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Qualified Partner — East China API Works | 5-Fluoro-2-oxindole Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Unibest Nantong cGMP Site | 5-Formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
本页为中间体 CAS 注册档案：同 CAS 的多条路线登记已合并；后续供应商报价与买方需求以该 CAS 为主键撮合。