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CAS 147255-16-1
(4R)-4-(3,4-Dichlorophenyl)-4-phenylbutanoic acid
登记编号：Sertraline Hydrochloride-066
应用背景（按来源药适应症）
强迫性障碍枸橼酸舍曲林
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| 枸橼酸舍曲林Sertraline Citrate | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
(4R)-4-(3,4-Dichlorophenyl)-4-phenylbutanoic acid→4-(3,4-Dichlorophenyl)-4-phenylbutanoyl chloride→Carbamic acid methyl ester→methyl N-[4-(3,4-dichlorophenyl)-4-phenylbutanoyl]carbamate→methyl N-[4-(3,4-dichlorophenyl)-1-hydroxy-4-phenylbutyl]carbamate→Ethyl [(1S,4S)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-yl]carbamate
Ethenylbenzene→Methyl (3E)-2-diazo-4-phenylbut-3-enoate→methyl (2S)-2-phenyl-1-[(E)-2-phenylethenyl]cyclopropane-1-carboxylate→1,1-dimethyl (2S)-2-phenylcyclopropane-1,1-dicarboxylate→3,4-Dichlorotoluene→1,3-dimethyl 2-[(2R)-2-(3,4-dichlorophenyl)-2-phenylethyl]propanedioate→(4R)-4-(3,4-Dichlorophenyl)-4-phenylbutanoic acid→4(S)-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-one
(3,4-Dichlorophenyl)(phenyl)methanone→Butane-1,4-dioic acid diethyl diester→ethyl (3E)-4-(3,4-dichlorophenyl)-4-phenylbut-3-enoate→(2E)-4-(3,4-Dichlorophenyl)-4-phenylbut-2-enoic acid→(3E)-4-(3,4-dichlorophenyl)-4-phenylbut-3-enoate; 2-methylpropan-2-aminium→(4R)-4-(3,4-dichlorophenyl)-4-phenylbutanoate; 2-methylpropan-2-aminium→(4R)-4-(3,4-Dichlorophenyl)-4-phenylbutanoic acid→4(S)-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-one
Benzaldehyde→Allyl(bromo)magnesium→1-Phenylbut-3-en-1-ol→(1S)-1-Phenylbut-3-en-1-ol→N,N-Diisopropylcarbamic chloride→(1S)-1-Phenylbut-3-en-1-yl dipropan-2-ylcarbamate→2-(3,4-Dichlorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane→(3,4-Dichlorophenyl)boronic acid→2,3-Dimethyl-2,3-butanediol→2-[(1R)-1-(3,4-Dichlorophenyl)-1-phenylbut-3-en-1-yl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane→1,2-Dichloro-4-[(1R)-1-phenylbut-3-en-1-yl]benzene→(4R)-4-(3,4-Dichlorophenyl)-4-phenylbutanoic acid→4(S)-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-one→N-Methylhydroxylamine→N-[(1E,4S)-4-(3,4-Dichlorophenyl)-3,4-dihydronaphthalen-1(2H)-ylidene]methanamine→(1S,4S)-4-(3,4-Dichlorophenyl)-N-methyltetralin-1-amine
4-(3,4-Dichlorophenyl)-4-oxobutanoic acid→4-(3,4-Dichlorophenyl)-4-hydroxybutanoic acid→(5R)-5-(3,4-Dichlorophenyl)oxolan-2-one→(1R)-1-(3,4-Dichlorophenyl)butane-1,4-diol→(1R)-1-(3,4-Dichlorophenyl)-4-[[(2,3,3-trimethylbutan-2-yl)silyl]oxy]butan-1-ol→(4R)-4-(3,4-Dichlorophenyl)-4-phenylbutanoic acid→(1R)-1-(3,4-Dichlorophenyl)-4-[[(2,3,3-trimethylbutan-2-yl)silyl]oxy]butyl methanesulfonate→Phenyllithium→[(4R)-4-(3,4-Dichlorophenyl)-4-phenylbutoxy](2,3,3-trimethylbutan-2-yl)silane→(4R)-4-(3,4-Dichlorophenyl)-4-phenylbutan-1-ol
(2E)-3-(3,4-Dichlorophenyl)acrylaldehyde→1,1-Dimethylethyl isocyanide→(3E)-N-tert-Butyl-4-(3,4-dichlorophenyl)-2-oxobut-3-enamide→(4R)-N-tert-Butyl-4-(3,4-dichlorophenyl)-2-oxo-4-phenylbutanamide→(2Z,4R)-N-tert-Butyl-4-(3,4-dichlorophenyl)-2-hydrazono-4-phenylbutanamide→(4R)-N-tert-Butyl-4-(3,4-dichlorophenyl)-4-phenylbutanamide→N-tert-Butyl-2-[(2R)-2-(3,4-dichlorophenyl)-2-phenylethyl]-1,3-dithiolane-2-carboxamide→(4R)-4-(3,4-Dichlorophenyl)-4-phenylbutanoic acid→4(S)-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-one→1,3-Bis(bromanyl)benzene→(R)-S-tert-Butyl 2-methylpropane-2-sulfinothioate→1,3-Bis[(R)-tert-butylsulfinyl]benzene→Chlorodiphenylphosphane→Sertraline Hydrochloride-138→phenylboronic acid
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