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CAS 79617-96-2
(1S,4S)-4-(3,4-Dichlorophenyl)-N-methyltetralin-1-amine
登记编号：Sertraline Hydrochloride-025
应用背景（按来源药适应症）
强迫性障碍枸橼酸舍曲林
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| 枸橼酸舍曲林Sertraline Citrate | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
Benzene→3,4-Dichlorobenzoyl chloride→(3,4-Dichlorophenyl)(phenyl)methanone→1,2-Dichloro-4-(1-phenylethenyl)benzene→Butane-1,4-dioic acid diethyl diester→1,4-Diethyl (2Z)-2-[(3,4-dichlorophenyl)(phenyl)methylidene]butanedioate→4-(3,4-Dichlorophenyl)-4-phenylbut-3-enoic acid→4-(3,4-Dichlorophenyl)-4-phenylbutanoic acid→4-(3,4-Dichlorophenyl)-4-phenylbutanoyl chloride→4-(3,4-Dichlorophenyl)-1-tetralone→4-(2,3-Dichlorophenyl)-1-tetralone→1,2-Dichlorobenzene→Aminomethane→N-[(1E)-4-(3,4-Dichlorophenyl)-3,4-dihydronaphthalen-1(2H)-ylidene]methanamine→(1S,4S)-4-(3,4-Dichlorophenyl)-N-methyltetralin-1-amine
(1R)-1,2-dihydronaphthalen-1-ol→tert-Butyl[(1R)-1,2-dihydronaphthalen-1-yloxy]diphenylsilane→[[(1R)-4-Bromo-1,2-dihydronaphthalen-1-yl]oxy](tert-butyl)diphenylsilane→(3,4-Dichlorophenyl)(trimethyl)stannane→3,4-Dichlorophenol→3,4-Dichlorophenyl trifluoromethanesulfonate→tert-Butyl[[(1R)-4-(3,4-dichlorophenyl)-1,2-dihydronaphthalen-1-yl]oxy]diphenylsilane→(3,4-Dichlorophenyl)boronic acid→(1R)-4-(3,4-Dichlorophenyl)-1,2-dihydronaphthalen-1-ol→(1R,4S)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-ol→(1S,4S)-1-Azido-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalene→4(S)-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1(S)-amine→Carbonochloridic acid ethyl ester→Ethyl [(1S,4S)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-yl]carbamate→(1S,4S)-4-(3,4-Dichlorophenyl)-N-methyltetralin-1-amine
1-Hydroxynaphthalene→1,2-Dichlorobenzene→4(S)-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-one→N-Methylhydroxylamine→1-(3,4-dichlorophenyl)-4-(methylnitroso)-1,2,3,4-tetrahydronaphthalene→(1S,4S)-4-(3,4-Dichlorophenyl)-N-methyltetralin-1-amine
4-(3,4-Dichlorophenyl)-1-tetralone→Aminomethane→N-[(1E)-4-(3,4-Dichlorophenyl)-3,4-dihydronaphthalen-1(2H)-ylidene]methanamine→(±)-cis-4-(3,4-Dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine→(1S,4S)-4-(3,4-Dichlorophenyl)-N-methyltetralin-1-amine→(2R)-Hydroxy(phenyl)acetic acid (1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine
4-(3,4-Dichlorophenyl)-1-tetralone→Aminomethane→N-[(1E)-4-(3,4-Dichlorophenyl)-3,4-dihydronaphthalen-1(2H)-ylidene]methanamine→(±)-cis/trans 4-(3,4-Dichlorophenyl)-N-methyl-1,2,3,4-tetrahydro-1-naphthalenamine→(±)-4-(3,4-Dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine→(1S,4S)-4-(3,4-Dichlorophenyl)-N-methyltetralin-1-amine
Benzaldehyde→Allyl(bromo)magnesium→1-Phenylbut-3-en-1-ol→(1S)-1-Phenylbut-3-en-1-ol→N,N-Diisopropylcarbamic chloride→(1S)-1-Phenylbut-3-en-1-yl dipropan-2-ylcarbamate→2-(3,4-Dichlorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane→(3,4-Dichlorophenyl)boronic acid→2,3-Dimethyl-2,3-butanediol→2-[(1R)-1-(3,4-Dichlorophenyl)-1-phenylbut-3-en-1-yl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane→1,2-Dichloro-4-[(1R)-1-phenylbut-3-en-1-yl]benzene→(4R)-4-(3,4-Dichlorophenyl)-4-phenylbutanoic acid→4(S)-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-one→N-Methylhydroxylamine→N-[(1E,4S)-4-(3,4-Dichlorophenyl)-3,4-dihydronaphthalen-1(2H)-ylidene]methanamine→(1S,4S)-4-(3,4-Dichlorophenyl)-N-methyltetralin-1-amine
1-Hydroxynaphthalene→1,2-Dichlorobenzene→4-(3,4-Dichlorophenyl)-1-tetralone→(1S,4S)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-ol→(1S,4S)-1-(Benzyloxy)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalene→Benzyl [(1S,4S)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-yl]carbamate→Benzyl [(1S,4S)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-yl]methylcarbamate→(1S,4S)-4-(3,4-Dichlorophenyl)-N-methyltetralin-1-amine
4-(3,4-Dichlorophenyl)-1-tetralone→(1S,4S)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-ol→4(S)-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-one→Aminomethane→N-[(1E,4S)-4-(3,4-Dichlorophenyl)-3,4-dihydronaphthalen-1(2H)-ylidene]methanamine→(1S,4S)-4-(3,4-Dichlorophenyl)-N-methyltetralin-1-amine→[5,5'-Biquinoline]-6,6'-diol→Sertraline Hydrochloride-157
4-Benzylbutyric acid→1,3-Dioxo-2,3-dihydro-1H-isoindol-2-yl 5-phenylpentanoate→1,2,3,4-Tetrahydronaphthalene→1-Oxotetralin→1,1,1-Trifluoro-N-methyl-N-(4-oxo-1,2,3,4-tetrahydronaphthalen-1-yl)methanesulfonamide→Iodomethane→1,1,1-Trifluoro-N-(4-oxo-1,2,3,4-tetrahydronaphthalen-1-yl)methanesulfonamide→4-[Methyl(trifluoromethanesulfonyl)amino]-3,4-dihydronaphthalen-1-yl trifluoromethanesulfonate→(3,4-Dichlorophenyl)boronic acid→N-[4-(3,4-Dichlorophenyl)-1,2-dihydronaphthalen-1-yl]-1,1,1-trifluoro-N-methylmethanesulfonamide→N-[(1S,4S)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-yl]-1,1,1-trifluoro-N-methylmethanesulfonamide→(1S,4S)-4-(3,4-Dichlorophenyl)-N-methyltetralin-1-amine
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