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枸橼酸舍曲林
Tier C · 观察 / 贸易Sertraline Citrate
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原研
2008
首批上市
-
到期年（公开口径）
无销量数据
峰值销售
化学药
类型
靶点：SERT
适应症（已批准）：强迫性障碍
各地区研发/上市状态
美国
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欧盟
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中国
批准上市
2008-03-18
日本
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合成路线与中间体29 routes
原研路线 × 0优化路线（非专利）× 29工艺路线 × 0
路线按「原研路线 → 优化路线 / 工艺路线（非专利）」排序。每条路线附本站自绘的路线流程图（中间体 → 原料药）与中间体表（编号 / CAS / 英文名），可直接用于供应商开发与询价。流程图由本站依据已授权的结构化数据自行渲染，未使用任何第三方路线图。
优化Route 1步骤 9 · 总收率 /
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Sertraline Hydrochloride-001 | 147514-83-8 | 7-bromo-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine |
| Sertraline Hydrochloride-002 | 147462-26-8 | (1R)-7-Bromo-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine |
| Sertraline Hydrochloride-003 | 147462-27-9 | N-[(1R)-7-Bromo-1,2,3,4-tetrahydronaphthalen-1-yl]-N-methylformamide |
| Sertraline Hydrochloride-004 | 147462-28-0 | N-[(1R)-7-Bromo-4-oxo-1,2,3,4-tetrahydronaphthalen-1-yl]-N-methylformamide |
| Sertraline Hydrochloride-005 | - | 3,4-Dichlorophenylmagnesium bromide |
| Sertraline Hydrochloride-006 | 147462-29-1 | N-[(1R,4S)-7-bromo-4-(3,4-dichlorophenyl)-4-hydroxy-1,2,3,4-tetrahydronaphthalen-1-yl]-N-methylformamide |
| Sertraline Hydrochloride-007 | 147462-30-4 | N-[(1R,4S)-7-bromo-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-yl]-N-methylformamide |
| Sertraline Hydrochloride-008 | 754157-48-7 | (1R,4S)-7-bromo-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine |
| Sertraline Hydrochloride-009 | 1027935-40-5 | (1E,4S)-7-bromo-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-imine |
| Sertraline Hydrochloride-010 | 791033-90-4 | (1S,4S)-7-bromo-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine |
优化Route 2步骤 10 · 总收率 65g(Sertraline (Free))
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Sertraline Hydrochloride-011 | - | Benzene |
| Sertraline Hydrochloride-012 | - | 3,4-Dichlorobenzoyl chloride |
| Sertraline Hydrochloride-013 | - | (3,4-Dichlorophenyl)(phenyl)methanone |
| Sertraline Hydrochloride-014 | 1093645-86-3 | 1,2-Dichloro-4-(1-phenylethenyl)benzene |
| Sertraline Hydrochloride-015 | - | Butane-1,4-dioic acid diethyl diester |
| Sertraline Hydrochloride-016 | - | 1,4-Diethyl (2Z)-2-[(3,4-dichlorophenyl)(phenyl)methylidene]butanedioate |
| Sertraline Hydrochloride-017 | 618910-81-9 | 4-(3,4-Dichlorophenyl)-4-phenylbut-3-enoic acid |
| Sertraline Hydrochloride-018 | - | 4-(3,4-Dichlorophenyl)-4-phenylbutanoic acid |
| Sertraline Hydrochloride-019 | - | 4-(3,4-Dichlorophenyl)-4-phenylbutanoyl chloride |
| Sertraline Hydrochloride-020 | - | 4-(3,4-Dichlorophenyl)-1-tetralone |
| Sertraline Hydrochloride-021 | - | 4-(2,3-Dichlorophenyl)-1-tetralone |
| Sertraline Hydrochloride-022 | - | 1,2-Dichlorobenzene |
| Sertraline Hydrochloride-023 | - | Aminomethane |
| Sertraline Hydrochloride-024 | - | N-[(1E)-4-(3,4-Dichlorophenyl)-3,4-dihydronaphthalen-1(2H)-ylidene]methanamine |
| Sertraline Hydrochloride-025 | 79617-96-2 | (1S,4S)-4-(3,4-Dichlorophenyl)-N-methyltetralin-1-amine |
优化Route 3步骤 12 · 总收率 /
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Sertraline Hydrochloride-026 | 123849-23-0 | (1R)-1,2-dihydronaphthalen-1-ol |
| Sertraline Hydrochloride-027 | 195388-52-4 | tert-Butyl[(1R)-1,2-dihydronaphthalen-1-yloxy]diphenylsilane |
| Sertraline Hydrochloride-028 | 195388-53-5 | [[(1R)-4-Bromo-1,2-dihydronaphthalen-1-yl]oxy](tert-butyl)diphenylsilane |
| Sertraline Hydrochloride-029 | 119704-60-8 | (3,4-Dichlorophenyl)(trimethyl)stannane |
| Sertraline Hydrochloride-030 | - | 3,4-Dichlorophenol |
| Sertraline Hydrochloride-031 | 243661-79-2 | 3,4-Dichlorophenyl trifluoromethanesulfonate |
| Sertraline Hydrochloride-032 | 195388-54-6 | tert-Butyl[[(1R)-4-(3,4-dichlorophenyl)-1,2-dihydronaphthalen-1-yl]oxy]diphenylsilane |
| Sertraline Hydrochloride-033 | - | (3,4-Dichlorophenyl)boronic acid |
| Sertraline Hydrochloride-034 | 195388-55-7 | (1R)-4-(3,4-Dichlorophenyl)-1,2-dihydronaphthalen-1-ol |
| Sertraline Hydrochloride-035 | 167026-40-6 | (1R,4S)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-ol |
| Sertraline Hydrochloride-036 | 195388-56-8 | (1S,4S)-1-Azido-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalene |
| Sertraline Hydrochloride-037 | - | 4(S)-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1(S)-amine |
| Sertraline Hydrochloride-038 | - | Carbonochloridic acid ethyl ester |
| Sertraline Hydrochloride-039 | - | Ethyl [(1S,4S)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-yl]carbamate |
| Sertraline Hydrochloride-025 | 79617-96-2 | (1S,4S)-4-(3,4-Dichlorophenyl)-N-methyltetralin-1-amine |
优化Route 4步骤 4 · 总收率 /
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Sertraline Hydrochloride-034 | 195388-55-7 | (1R)-4-(3,4-Dichlorophenyl)-1,2-dihydronaphthalen-1-ol |
| Sertraline Hydrochloride-040 | - | 2,3-Dihydronaphthalene-1,4-dione |
| Sertraline Hydrochloride-041 | 412020-55-4 | (4R)-4-Hydroxy-3,4-dihydronaphthalen-1(2H)-one |
| Sertraline Hydrochloride-042 | 774244-52-9 | (4R)-4-[[tert-Butyl(dimethyl)silyl]oxy]-3,4-dihydronaphthalen-1(2H)-one |
| Sertraline Hydrochloride-005 | - | 3,4-Dichlorophenylmagnesium bromide |
| Sertraline Hydrochloride-043 | - | 4-bromo-1,2-dichlorobenzene |
| Sertraline Hydrochloride-044 | - | - |
优化Route 5步骤 11 · 总收率 /
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Sertraline Hydrochloride-045 | 267884-78-6 | methyl (2R)-2-(dibenzylamino)-2-phenylacetate |
| Sertraline Hydrochloride-046 | 193476-02-7 | (2R)-2-(dibenzylamino)-2-phenylethanol |
| Sertraline Hydrochloride-047 | 174023-92-8 | (2R)-2-(dibenzylamino)-2-phenylacetaldehyde |
| Sertraline Hydrochloride-048 | - | (Carbethoxymethylene)triphenylphosphorane |
| Sertraline Hydrochloride-049 | 267884-79-7 | ethyl (2E,4S)-4-(dibenzylamino)-4-phenylbut-2-enoate |
| Sertraline Hydrochloride-050 | 267884-80-0 | methyl (4S)-4-(dibenzylamino)-4-phenylbutanoate |
| Sertraline Hydrochloride-051 | 267884-81-1 | (4S)-4-(dibenzylamino)-4-phenylbutan-1-ol |
| Sertraline Hydrochloride-052 | - | (4S)-4-(dibenzylamino)-4-phenylbutanal |
| Sertraline Hydrochloride-005 | - | 3,4-Dichlorophenylmagnesium bromide |
| Sertraline Hydrochloride-053 | 267884-77-5 | (4S)-4-(dibenzylamino)-1-(3,4-dichlorophenyl)-4-phenylbutan-1-ol |
| Sertraline Hydrochloride-054 | 267884-82-2 | (1S,4S)-N,N-dibenzyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-amine |
| Sertraline Hydrochloride-055 | 267884-84-4 | tert-Butyl [(1S,4S)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-yl]carbamate |
| Sertraline Hydrochloride-056 | 267884-85-5 | tert-butyl N-[(1S,4S)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-yl]-N-methylcarbamate |
优化Route 6步骤 6 · 总收率 22.5g(Sertraline Hydrochloride (API))
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Sertraline Hydrochloride-022 | - | 1,2-Dichlorobenzene |
| Sertraline Hydrochloride-057 | - | 2,5-Dioxotetrahydrofuran |
| Sertraline Hydrochloride-058 | - | 4-(3,4-Dichlorophenyl)-4-oxobutanoic acid |
| Sertraline Hydrochloride-059 | 95609-48-6 | 5-(3,4-Dichlorophenyl)oxolan-2-one |
| Sertraline Hydrochloride-011 | - | Benzene |
| Sertraline Hydrochloride-020 | - | 4-(3,4-Dichlorophenyl)-1-tetralone |
| Sertraline Hydrochloride-024 | - | N-[(1E)-4-(3,4-Dichlorophenyl)-3,4-dihydronaphthalen-1(2H)-ylidene]methanamine |
| Sertraline Hydrochloride-060 | - | (±)-cis-4-(3,4-Dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine |
| Sertraline Hydrochloride-061 | - | (±)-cis-4-(3,4-Dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine hydrogen chloride |
优化Route 7步骤 4 · 总收率 /
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Sertraline Hydrochloride-062 | - | 1-Hydroxynaphthalene |
| Sertraline Hydrochloride-022 | - | 1,2-Dichlorobenzene |
| Sertraline Hydrochloride-063 | - | 4(S)-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-one |
| Sertraline Hydrochloride-064 | - | N-Methylhydroxylamine |
| Sertraline Hydrochloride-065 | - | 1-(3,4-dichlorophenyl)-4-(methylnitroso)-1,2,3,4-tetrahydronaphthalene |
| Sertraline Hydrochloride-025 | 79617-96-2 | (1S,4S)-4-(3,4-Dichlorophenyl)-N-methyltetralin-1-amine |
优化Route 8步骤 5 · 总收率 /
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Sertraline Hydrochloride-066 | 147255-16-1 | (4R)-4-(3,4-Dichlorophenyl)-4-phenylbutanoic acid |
| Sertraline Hydrochloride-019 | - | 4-(3,4-Dichlorophenyl)-4-phenylbutanoyl chloride |
| Sertraline Hydrochloride-067 | 598-55-0 | Carbamic acid methyl ester |
| Sertraline Hydrochloride-068 | 374778-33-3 | methyl N-[4-(3,4-dichlorophenyl)-4-phenylbutanoyl]carbamate |
| Sertraline Hydrochloride-069 | 848130-45-0 | methyl N-[4-(3,4-dichlorophenyl)-1-hydroxy-4-phenylbutyl]carbamate |
| Sertraline Hydrochloride-039 | - | Ethyl [(1S,4S)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-yl]carbamate |
优化Route 9步骤 3 · 总收率 33.5g(Sertraline (Free))
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Sertraline Hydrochloride-020 | - | 4-(3,4-Dichlorophenyl)-1-tetralone |
| Sertraline Hydrochloride-023 | - | Aminomethane |
| Sertraline Hydrochloride-024 | - | N-[(1E)-4-(3,4-Dichlorophenyl)-3,4-dihydronaphthalen-1(2H)-ylidene]methanamine |
| Sertraline Hydrochloride-060 | - | (±)-cis-4-(3,4-Dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine |
| Sertraline Hydrochloride-025 | 79617-96-2 | (1S,4S)-4-(3,4-Dichlorophenyl)-N-methyltetralin-1-amine |
| Sertraline Hydrochloride-071 | - | (2R)-Hydroxy(phenyl)acetic acid (1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine |
优化Route 10步骤 5 · 总收率 /
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Sertraline Hydrochloride-070 | - | Ethenylbenzene |
| Sertraline Hydrochloride-072 | 119987-21-2 | Methyl (3E)-2-diazo-4-phenylbut-3-enoate |
| Sertraline Hydrochloride-073 | - | methyl (2S)-2-phenyl-1-[(E)-2-phenylethenyl]cyclopropane-1-carboxylate |
| Sertraline Hydrochloride-074 | 158800-60-3 | 1,1-dimethyl (2S)-2-phenylcyclopropane-1,1-dicarboxylate |
| Sertraline Hydrochloride-075 | 95-75-0 | 3,4-Dichlorotoluene |
| Sertraline Hydrochloride-076 | 158723-71-8 | 1,3-dimethyl 2-[(2R)-2-(3,4-dichlorophenyl)-2-phenylethyl]propanedioate |
| Sertraline Hydrochloride-066 | 147255-16-1 | (4R)-4-(3,4-Dichlorophenyl)-4-phenylbutanoic acid |
| Sertraline Hydrochloride-063 | - | 4(S)-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-one |
优化Route 11步骤 6 · 总收率 /
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Sertraline Hydrochloride-013 | - | (3,4-Dichlorophenyl)(phenyl)methanone |
| Sertraline Hydrochloride-015 | - | Butane-1,4-dioic acid diethyl diester |
| Sertraline Hydrochloride-077 | - | ethyl (3E)-4-(3,4-dichlorophenyl)-4-phenylbut-3-enoate |
| Sertraline Hydrochloride-078 | - | (2E)-4-(3,4-Dichlorophenyl)-4-phenylbut-2-enoic acid |
| Sertraline Hydrochloride-079 | 618910-82-0 | (3E)-4-(3,4-dichlorophenyl)-4-phenylbut-3-enoate; 2-methylpropan-2-aminium |
| Sertraline Hydrochloride-080 | 618910-83-1 | (4R)-4-(3,4-dichlorophenyl)-4-phenylbutanoate; 2-methylpropan-2-aminium |
| Sertraline Hydrochloride-066 | 147255-16-1 | (4R)-4-(3,4-Dichlorophenyl)-4-phenylbutanoic acid |
| Sertraline Hydrochloride-063 | - | 4(S)-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-one |
优化Route 12步骤 4 · 总收率 139g(Sertraline Hydrochloride (API))
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Sertraline Hydrochloride-020 | - | 4-(3,4-Dichlorophenyl)-1-tetralone |
| Sertraline Hydrochloride-023 | - | Aminomethane |
| Sertraline Hydrochloride-024 | - | N-[(1E)-4-(3,4-Dichlorophenyl)-3,4-dihydronaphthalen-1(2H)-ylidene]methanamine |
| Sertraline Hydrochloride-081 | - | (±)-cis/trans 4-(3,4-Dichlorophenyl)-N-methyl-1,2,3,4-tetrahydro-1-naphthalenamine |
| Sertraline Hydrochloride-082 | - | (±)-4-(3,4-Dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine |
| Sertraline Hydrochloride-025 | 79617-96-2 | (1S,4S)-4-(3,4-Dichlorophenyl)-N-methyltetralin-1-amine |
优化Route 13步骤 10 · 总收率 /
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Sertraline Hydrochloride-083 | - | Benzaldehyde |
| Sertraline Hydrochloride-084 | 1730-25-2 | Allyl(bromo)magnesium |
| Sertraline Hydrochloride-085 | 936-58-3 | 1-Phenylbut-3-en-1-ol |
| Sertraline Hydrochloride-086 | 77118-87-7 | (1S)-1-Phenylbut-3-en-1-ol |
| Sertraline Hydrochloride-087 | 19009-39-3 | N,N-Diisopropylcarbamic chloride |
| Sertraline Hydrochloride-088 | 1063723-88-5 | (1S)-1-Phenylbut-3-en-1-yl dipropan-2-ylcarbamate |
| Sertraline Hydrochloride-089 | 401797-02-2 | 2-(3,4-Dichlorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane |
| Sertraline Hydrochloride-033 | - | (3,4-Dichlorophenyl)boronic acid |
| Sertraline Hydrochloride-090 | - | 2,3-Dimethyl-2,3-butanediol |
| Sertraline Hydrochloride-091 | 1338922-77-2 | 2-[(1R)-1-(3,4-Dichlorophenyl)-1-phenylbut-3-en-1-yl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane |
| Sertraline Hydrochloride-092 | 1338922-76-1 | 1,2-Dichloro-4-[(1R)-1-phenylbut-3-en-1-yl]benzene |
| Sertraline Hydrochloride-066 | 147255-16-1 | (4R)-4-(3,4-Dichlorophenyl)-4-phenylbutanoic acid |
| Sertraline Hydrochloride-063 | - | 4(S)-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-one |
| Sertraline Hydrochloride-064 | - | N-Methylhydroxylamine |
| Sertraline Hydrochloride-093 | 1186422-36-5 | N-[(1E,4S)-4-(3,4-Dichlorophenyl)-3,4-dihydronaphthalen-1(2H)-ylidene]methanamine |
| Sertraline Hydrochloride-025 | 79617-96-2 | (1S,4S)-4-(3,4-Dichlorophenyl)-N-methyltetralin-1-amine |
优化Route 14步骤 8 · 总收率 /
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Sertraline Hydrochloride-058 | - | 4-(3,4-Dichlorophenyl)-4-oxobutanoic acid |
| Sertraline Hydrochloride-094 | 118528-87-3 | 4-(3,4-Dichlorophenyl)-4-hydroxybutanoic acid |
| Sertraline Hydrochloride-095 | 147189-93-3 | (5R)-5-(3,4-Dichlorophenyl)oxolan-2-one |
| Sertraline Hydrochloride-096 | 147189-94-4 | (1R)-1-(3,4-Dichlorophenyl)butane-1,4-diol |
| Sertraline Hydrochloride-097 | - | (1R)-1-(3,4-Dichlorophenyl)-4-[[(2,3,3-trimethylbutan-2-yl)silyl]oxy]butan-1-ol |
| Sertraline Hydrochloride-066 | 147255-16-1 | (4R)-4-(3,4-Dichlorophenyl)-4-phenylbutanoic acid |
| Sertraline Hydrochloride-098 | - | (1R)-1-(3,4-Dichlorophenyl)-4-[[(2,3,3-trimethylbutan-2-yl)silyl]oxy]butyl methanesulfonate |
| Sertraline Hydrochloride-099 | - | Phenyllithium |
| Sertraline Hydrochloride-100 | - | [(4R)-4-(3,4-Dichlorophenyl)-4-phenylbutoxy](2,3,3-trimethylbutan-2-yl)silane |
| Sertraline Hydrochloride-101 | 147189-98-8 | (4R)-4-(3,4-Dichlorophenyl)-4-phenylbutan-1-ol |
优化Route 15步骤 5 · 总收率 /
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Sertraline Hydrochloride-058 | - | 4-(3,4-Dichlorophenyl)-4-oxobutanoic acid |
| Sertraline Hydrochloride-099 | - | Phenyllithium |
| Sertraline Hydrochloride-063 | - | 4(S)-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-one |
| Sertraline Hydrochloride-103 | 147189-99-9 | tert-Butyl 4-(3,4-dichlorophenyl)-4-oxobutanoate |
| Sertraline Hydrochloride-104 | 147190-00-9 | tert-Butyl (4R)-4-(3,4-dichlorophenyl)-4-hydroxybutanoate |
| Sertraline Hydrochloride-102 | 147190-01-0 | tert-Butyl (4R)-4-(3,4-dichlorophenyl)-4-[(methanesulfonyl)oxy]butanoate |
| Sertraline Hydrochloride-105 | 147189-42-2 | tert-Butyl (4R)-4-(3,4-dichlorophenyl)-4-phenylbutanoate |
优化Route 16步骤 4 · 总收率 /
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Sertraline Hydrochloride-095 | 147189-93-3 | (5R)-5-(3,4-Dichlorophenyl)oxolan-2-one |
| Sertraline Hydrochloride-022 | - | 1,2-Dichlorobenzene |
| Sertraline Hydrochloride-106 | - | 2-Chloranylethanoyl chloride |
| Sertraline Hydrochloride-107 | 42981-08-8 | 2-Chloro-1-(3,4-dichlorophenyl)ethan-1-one |
| Sertraline Hydrochloride-108 | 256474-24-5 | (1S)-2-Chloro-1-(3,4-dichlorophenyl)ethan-1-ol |
| Sertraline Hydrochloride-109 | 256474-26-7 | (2S)-2-(3,4-Dichlorophenyl)oxirane |
| Sertraline Hydrochloride-110 | - | Carbethoxyacetic ester |
优化Route 17步骤 2 · 总收率 /
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Sertraline Hydrochloride-058 | - | 4-(3,4-Dichlorophenyl)-4-oxobutanoic acid |
| Sertraline Hydrochloride-095 | 147189-93-3 | 2(3H)-Furanone, 5-(3,4-dichlorophenyl)dihydro-, (5R)- |
| Sertraline Hydrochloride-111 | 150739-31-4 | (4R)-4-(3,4-Dichlorophenyl)-4-hydroxybutanoic acid |
优化Route 18步骤 7 · 总收率 /
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Sertraline Hydrochloride-062 | - | 1-Hydroxynaphthalene |
| Sertraline Hydrochloride-022 | - | 1,2-Dichlorobenzene |
| Sertraline Hydrochloride-020 | - | 4-(3,4-Dichlorophenyl)-1-tetralone |
| Sertraline Hydrochloride-112 | 167026-37-1 | (1S,4S)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-ol |
| Sertraline Hydrochloride-113 | 1346228-87-2 | (1S,4S)-1-(Benzyloxy)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalene |
| Sertraline Hydrochloride-114 | 1346228-88-3 | Benzyl [(1S,4S)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-yl]carbamate |
| Sertraline Hydrochloride-115 | 1346228-89-4 | Benzyl [(1S,4S)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-yl]methylcarbamate |
| Sertraline Hydrochloride-025 | 79617-96-2 | (1S,4S)-4-(3,4-Dichlorophenyl)-N-methyltetralin-1-amine |
优化Route 19步骤 7 · 总收率 /
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Sertraline Hydrochloride-116 | - | 2-Ethenylbenzaldehyde |
| Sertraline Hydrochloride-117 | - | (R)-(+)-2-Methyl-2-propanesulfinamide |
| Sertraline Hydrochloride-118 | 1446433-95-9 | N-[(E)-(2-Ethenylphenyl)methylidene]-2-methylpropane-2-sulfinamide |
| Sertraline Hydrochloride-119 | 18925-10-5 | Allyl(bromo)zinc |
| Sertraline Hydrochloride-120 | 1446434-14-5 | N-[(1S)-1,2-Dihydronaphthalen-1-yl]-2-methylpropane-2-sulfinamide |
| Sertraline Hydrochloride-121 | 1446469-35-7 | (1S)-1,2-Dihydronaphthalen-1-amine |
| Sertraline Hydrochloride-122 | 1446434-26-9 | tert-Butyl (1S)-1,2-dihydronaphthalen-1-ylcarbamate |
| Sertraline Hydrochloride-123 | 1446434-28-1 | tert-Butyl [(1S)-4-bromo-1,2-dihydronaphthalen-1-yl]carbamate |
| Sertraline Hydrochloride-033 | - | (3,4-Dichlorophenyl)boronic acid |
| Sertraline Hydrochloride-124 | 1446434-30-5 | tert-Butyl [(1S)-4-(3,4-dichlorophenyl)-1,2-dihydronaphthalen-1-yl]carbamate |
| Sertraline Hydrochloride-055 | 267884-84-4 | tert-Butyl [(1S,4S)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-yl]carbamate |
优化Route 20步骤 4 · 总收率 4.6g(Sertraline Hydrochloride (API))
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Sertraline Hydrochloride-062 | - | 1-Hydroxynaphthalene |
| Sertraline Hydrochloride-022 | - | 1,2-Dichlorobenzene |
| Sertraline Hydrochloride-020 | - | 4-(3,4-Dichlorophenyl)-1-tetralone |
| Sertraline Hydrochloride-023 | - | Aminomethane |
| Sertraline Hydrochloride-024 | - | N-[(1E)-4-(3,4-Dichlorophenyl)-3,4-dihydronaphthalen-1(2H)-ylidene]methanamine |
| Sertraline Hydrochloride-125 | - | 4-(3,4-Dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine hydrochloride |
优化Route 21步骤 10 · 总收率 /
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Sertraline Hydrochloride-126 | 62374-02-1 | (2E)-3-(3,4-Dichlorophenyl)acrylaldehyde |
| Sertraline Hydrochloride-127 | - | 1,1-Dimethylethyl isocyanide |
| Sertraline Hydrochloride-128 | 1637758-32-7 | (3E)-N-tert-Butyl-4-(3,4-dichlorophenyl)-2-oxobut-3-enamide |
| Sertraline Hydrochloride-130 | 1637758-69-0 | (4R)-N-tert-Butyl-4-(3,4-dichlorophenyl)-2-oxo-4-phenylbutanamide |
| Sertraline Hydrochloride-131 | 1637758-80-5 | (2Z,4R)-N-tert-Butyl-4-(3,4-dichlorophenyl)-2-hydrazono-4-phenylbutanamide |
| Sertraline Hydrochloride-132 | 1637758-15-6 | (4R)-N-tert-Butyl-4-(3,4-dichlorophenyl)-4-phenylbutanamide |
| Sertraline Hydrochloride-133 | 1637758-14-5 | N-tert-Butyl-2-[(2R)-2-(3,4-dichlorophenyl)-2-phenylethyl]-1,3-dithiolane-2-carboxamide |
| Sertraline Hydrochloride-066 | 147255-16-1 | (4R)-4-(3,4-Dichlorophenyl)-4-phenylbutanoic acid |
| Sertraline Hydrochloride-063 | - | 4(S)-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-one |
| Sertraline Hydrochloride-134 | - | 1,3-Bis(bromanyl)benzene |
| Sertraline Hydrochloride-135 | 67734-35-4 | (R)-S-tert-Butyl 2-methylpropane-2-sulfinothioate |
| Sertraline Hydrochloride-136 | 1637758-13-4 | 1,3-Bis[(R)-tert-butylsulfinyl]benzene |
| Sertraline Hydrochloride-137 | - | Chlorodiphenylphosphane |
| Sertraline Hydrochloride-138 | - | - |
| Sertraline Hydrochloride-129 | 98-80-6 | phenylboronic acid |
优化Route 22步骤 10 · 总收率 /
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Sertraline Hydrochloride-139 | - | 2-(2-Propynyloxy)tetrahydropyran |
| Sertraline Hydrochloride-140 | 82753-05-7 | 3-[Benzyl(dimethyl)silyl]prop-2-yn-1-ol |
| Sertraline Hydrochloride-141 | 729603-57-0 | (2E)-3-[Benzyl(dimethyl)silyl]prop-2-en-1-ol |
| Sertraline Hydrochloride-142 | 2222689-26-9 | (2E)-3-[Benzyl(dimethyl)silyl]prop-2-en-1-yl methanesulfonate |
| Sertraline Hydrochloride-143 | 170168-66-8 | Pentafluorophenyl phenylacetate |
| Sertraline Hydrochloride-144 | - | 2-Phenylacetic acid |
| Sertraline Hydrochloride-145 | 2362029-19-2 | tert-Butyl [(1S,3E)-4-[benzyl(dimethyl)silyl]-1-phenylbut-3-en-1-yl]carbamate |
| Sertraline Hydrochloride-146 | - | 1,2-Dichloro-4-iodobenzene |
| Sertraline Hydrochloride-147 | 1848192-83-5 | tert-Butyl [(1S,3E)-4-(3,4-dichlorophenyl)-1-phenylbut-3-en-1-yl]carbamate |
| Sertraline Hydrochloride-148 | - | N-[(Z)-Phenylmethylidene]carbamic acid tert-butyl ester |
| Sertraline Hydrochloride-149 | - | Acetaldehyde |
| Sertraline Hydrochloride-150 | - | N-Boc-3(S)-amino-3-phenylpropanaldehyde |
| Sertraline Hydrochloride-151 | - | [(3,4-Dichlorophenyl)methyl](triphenyl)phosphanium bromide |
| Sertraline Hydrochloride-152 | - | Iodomethane |
| Sertraline Hydrochloride-153 | 1848192-84-6 | tert-Butyl [(1S,3E)-4-(3,4-dichlorophenyl)-1-phenylbut-3-en-1-yl]methylcarbamate |
优化Route 23步骤 2 · 总收率 /
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Sertraline Hydrochloride-154 | - | 1-Chloro-1,2,3,4-tetrahydronaphthalene |
| Sertraline Hydrochloride-146 | - | 1,2-Dichloro-4-iodobenzene |
| Sertraline Hydrochloride-155 | 1026541-31-0 | (1S)-1-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydronaphthalene |
| Sertraline Hydrochloride-063 | - | 4(S)-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-one |
优化Route 24步骤 6 · 总收率 563mg(Sertraline Hydrochloride (API))
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Sertraline Hydrochloride-020 | - | 4-(3,4-Dichlorophenyl)-1-tetralone |
| Sertraline Hydrochloride-112 | 167026-37-1 | (1S,4S)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-ol |
| Sertraline Hydrochloride-063 | - | 4(S)-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-one |
| Sertraline Hydrochloride-023 | - | Aminomethane |
| Sertraline Hydrochloride-093 | 1186422-36-5 | N-[(1E,4S)-4-(3,4-Dichlorophenyl)-3,4-dihydronaphthalen-1(2H)-ylidene]methanamine |
| Sertraline Hydrochloride-025 | 79617-96-2 | (1S,4S)-4-(3,4-Dichlorophenyl)-N-methyltetralin-1-amine |
| Sertraline Hydrochloride-156 | - | [5,5'-Biquinoline]-6,6'-diol |
| Sertraline Hydrochloride-157 | - | - |
优化Route 25步骤 4 · 总收率 /
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Sertraline Hydrochloride-020 | - | 4-(3,4-Dichlorophenyl)-1-tetralone |
| Sertraline Hydrochloride-146 | - | 1,2-Dichloro-4-iodobenzene |
| Sertraline Hydrochloride-158 | - | (3,4-Dichlorophenyl)(iodido)zinc |
| Sertraline Hydrochloride-159 | - | 2-Bromoacetic acid ethyl ester |
| Sertraline Hydrochloride-070 | - | Ethenylbenzene |
| Sertraline Hydrochloride-160 | 2114320-34-0 | Ethyl 4-(3,4-dichlorophenyl)-4-phenylbutanoate |
| Sertraline Hydrochloride-161 | 68240-78-8 | (3,4-Dichlorophenyl)(phenyl)methanol |
| Sertraline Hydrochloride-162 | - | (1-Ethoxycyclopropoxy)trimethylsilane |
优化Route 26步骤 1 · 总收率 12.38g(Sertraline Hydrochloride (API))
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Sertraline Hydrochloride-061 | - | (±)-cis-4-(3,4-Dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine hydrogen chloride |
优化Route 27步骤 9 · 总收率 /
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Sertraline Hydrochloride-163 | - | 4-Benzylbutyric acid |
| Sertraline Hydrochloride-164 | - | 1,3-Dioxo-2,3-dihydro-1H-isoindol-2-yl 5-phenylpentanoate |
| Sertraline Hydrochloride-165 | - | 1,2,3,4-Tetrahydronaphthalene |
| Sertraline Hydrochloride-166 | - | 1-Oxotetralin |
| Sertraline Hydrochloride-167 | - | 1,1,1-Trifluoro-N-methyl-N-(4-oxo-1,2,3,4-tetrahydronaphthalen-1-yl)methanesulfonamide |
| Sertraline Hydrochloride-152 | - | Iodomethane |
| Sertraline Hydrochloride-168 | 2307735-30-2 | 1,1,1-Trifluoro-N-(4-oxo-1,2,3,4-tetrahydronaphthalen-1-yl)methanesulfonamide |
| Sertraline Hydrochloride-169 | - | 4-[Methyl(trifluoromethanesulfonyl)amino]-3,4-dihydronaphthalen-1-yl trifluoromethanesulfonate |
| Sertraline Hydrochloride-033 | - | (3,4-Dichlorophenyl)boronic acid |
| Sertraline Hydrochloride-170 | - | N-[4-(3,4-Dichlorophenyl)-1,2-dihydronaphthalen-1-yl]-1,1,1-trifluoro-N-methylmethanesulfonamide |
| Sertraline Hydrochloride-171 | - | N-[(1S,4S)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-yl]-1,1,1-trifluoro-N-methylmethanesulfonamide |
| Sertraline Hydrochloride-025 | 79617-96-2 | (1S,4S)-4-(3,4-Dichlorophenyl)-N-methyltetralin-1-amine |
优化Route 28步骤 3 · 总收率 /
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Sertraline Hydrochloride-172 | 2226657-65-2 | 1-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydronaphthalene |
| Sertraline Hydrochloride-173 | - | 2,2,2-Trichloroethoxysulfonamide |
| Sertraline Hydrochloride-174 | - | (±)-2,2,2-Trichloroethyl [(1S,4S)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-yl]sulfamate |
| Sertraline Hydrochloride-152 | - | Iodomethane |
| Sertraline Hydrochloride-175 | - | (±)-2,2,2-Trichloroethyl [(1S,4S)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-yl]methylsulfamate |
| Sertraline Hydrochloride-060 | - | (±)-cis-4-(3,4-Dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine |
优化Route 29步骤 6 · 总收率 /
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Sertraline Hydrochloride-083 | - | Benzaldehyde |
| Sertraline Hydrochloride-176 | - | 9-Aminofluorene |
| Sertraline Hydrochloride-177 | 1158082-39-3 | (E)-N-(9H-Fluoren-9-yl)-1-phenylmethanimine |
| Sertraline Hydrochloride-178 | 2010131-21-0 | tert-Butyl (2E)-3-(3,4-dichlorophenyl)prop-2-en-1-yl carbonate |
| Sertraline Hydrochloride-179 | 2041582-77-6 | N-[(1R,3E)-4-(3,4-Dichlorophenyl)-1-phenylbut-3-en-1-yl]-9H-fluoren-9-imine |
| Sertraline Hydrochloride-180 | - | (1R,3E)-4-(3,4-Dichlorophenyl)-1-phenylbut-3-en-1-amine hydrogen chloride |
| Sertraline Hydrochloride-181 | 2010135-47-2 | tert-Butyl [(1R,3E)-4-(3,4-dichlorophenyl)-1-phenylbut-3-en-1-yl]carbamate |
| Sertraline Hydrochloride-152 | - | Iodomethane |
| Sertraline Hydrochloride-182 | 2010131-89-0 | tert-Butyl [(1R,3E)-4-(3,4-dichlorophenyl)-1-phenylbut-3-en-1-yl]methylcarbamate |
| Sertraline Hydrochloride-183 | 79617-98-4 | (1R,4R)-4-(3,4-Dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine |
常见问题（FAQ）
枸橼酸舍曲林的适应症有哪些？
已批准的适应症包括：强迫性障碍。
枸橼酸舍曲林的专利什么时候到期？
枸橼酸舍曲林的专利到期年暂无公开口径，本页会在数据管道核实后更新。
枸橼酸舍曲林有几条合成路线？
本站收录 29 条合成路线，最短路线 1 步、总收率 12.38g(Sertraline Hydrochloride (API))。每条路线的中间体均带登记编号与 CAS 号。
枸橼酸舍曲林的关键中间体在哪里可以采购？
枸橼酸舍曲林路线中的中间体均已建立 CAS 档案，可直接按 CAS 发起询价，需求会进入供应网络撮合池。
如何获取枸橼酸舍曲林中间体的报价？
在本页选择目标中间体的 CAS 进入档案页，或在询价页直接提交需求；CAS 会自动带入供需撮合流程，由供应网络反馈报价。
数据来源：多源数据交叉核实（仅结构化字段） · 2026-09-24