盐酸羟考酮

Tier C · 观察 / 贸易

Oxycodone Hydrochloride Hydrate

原研

1998

首批上市

到期年（公开口径）

$0.05B ▲

峰值销售

化学药

类型

靶点：Opioid receptors

商品名：Oxygesic、OxiNorm、Oxycodone NT、Rexista Oxycodone XR、OxyContin、OxiFast、OROS-oxycodone、OXAYDO、Oxecta、Oxycodone DETERx、OxyContin Neo、Endone、OxyQD、Eubine、Roxicodone、Rexista、Acurox

适应症（已批准）：疼痛、急性疼痛、慢性疼痛

各地区研发/上市状态

美国

批准上市

1998-10-26

欧盟

无进展

2010-11-01

中国

批准上市

2004-01-21

日本

批准上市

2003-04-16

合成路线与中间体2 routes

原研路线 × 0优化路线（非专利）× 2工艺路线 × 0

路线按「原研路线 → 优化路线 / 工艺路线（非专利）」排序。每条路线附本站自绘的路线流程图（中间体 → 原料药）与中间体表（编号 / CAS / 英文名），可直接用于供应商开发与询价。流程图由本站依据已授权的结构化数据自行渲染，未使用任何第三方路线图。

优化Route 1步骤 2 · 总收率 1.51 g (Oxycodone)

OXYC-001115-37-7OXYC-002508-54-3Oxycodone76-42-6API · 盐酸羟考酮

编号	CAS 号	中间体名称
OXYC-001	115-37-7	(4R,7aR,12bS)-7,9-dimethoxy-3-methyl-2,3,4,7a-tetrahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline
OXYC-002	508-54-3	(4R,4aS,7aR,12bS)-4a-hydroxy-9-methoxy-3-methyl-2,3,4,4a-tetrahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7(7aH)-one
Oxycodone	76-42-6	(4R,4aS,7aR,12bS)-4a-hydroxy-9-methoxy-3-methyl-2,3,4,4a,5,6-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7(7aH)-one

优化Route 2步骤 22 · 总收率 3.4 mg (Oxycodone)

OXYC-0032973-58-2OXYC-004115961-42-7OXYC-0051638678-28-0OXYC-0061638678-29-1OXYC-0071638678-30-4OXYC-008—OXYC-009—OXYC-010—OXYC-0111638678-34-8OXYC-0121638678-38-2OXYC-0131638678-40-6OXYC-0141638678-42-8OXYC-01537517-81-0OXYC-0161638678-43-9OXYC-017—OXYC-0181638678-46-2OXYC-0191638678-47-3OXYC-020—OXYC-0211638678-50-8OXYC-0221638678-51-9OXYC-0231638678-52-0OXYC-0241638678-53-1OXYC-0251638678-54-2OXYC-026—API · 盐酸羟考酮

编号	CAS 号	中间体名称
OXYC-003	2973-58-2	2-bromo-3-hydroxy-4-methoxybenzaldehyde
OXYC-004	115961-42-7	2-bromo-4-methoxy-3-(methoxymethoxy)benzaldehyde
OXYC-005	1638678-28-0	(2-bromo-4-methoxy-3-(methoxymethoxy)phenyl)methanol
OXYC-006	1638678-29-1	2-bromo-1-(bromomethyl)-4-methoxy-3-(methoxymethoxy)benzene
OXYC-007	1638678-30-4	(R)-4-benzyl-3-(2-(4-(benzyloxy)phenyl)acetyl)oxazolidin-2-one
OXYC-008	-	(R)-4-benzyl-3-((R)-2-(4-(benzyloxy)-2-bromophenyl)-3-(4-methoxy-3-(methoxymethoxy)phenyl)propanoyl)oxazolidin-2-one
OXYC-009	-	(R)-2-(4-(benzyloxy)-2-bromophenyl)-3-(4-methoxy-3-(methoxymethoxy)phenyl)propanoic acid
OXYC-010	-	methyl (R)-2-(4-(benzyloxy)-2-bromophenyl)-3-(4-methoxy-3-(methoxymethoxy)phenyl)propanoate
OXYC-011	1638678-34-8	methyl (R)-6-(benzyloxy)-3-methoxy-4-(methoxymethoxy)-9,10-dihydrophenanthrene-9-carboxylate
OXYC-012	1638678-38-2	(R)-(6-hydroxy-3-methoxy-4-(methoxymethoxy)-9,10-dihydrophenanthren-9-yl)methyl acetate
OXYC-013	1638678-40-6	((8aR,9S)-8a-hydroxy-3-methoxy-4-(methoxymethoxy)-6-oxo-6,8a,9,10-tetrahydrophenanthren-9-yl)methyl acetate
OXYC-014	1638678-42-8	((8aR,9S)-8a-hydroxy-3-methoxy-4-(methoxymethoxy)-6-oxo-6,7,8,8a,9,10-hexahydrophenanthren-9-yl)methyl acetate
OXYC-015	37517-81-0	methyl 3-chloro-3-oxopropanoate
OXYC-016	1638678-43-9	(8aR,9S)-9-(acetoxymethyl)-3-methoxy-4-(methoxymethoxy)-6-oxo-7,8,9,10-tetrahydrophenanthren-8a(6H)-yl methyl malonate
OXYC-017	-	methyl (4bS,8aR,9S,13S)-9-(acetoxymethyl)-3-methoxy-4-(methoxymethoxy)-6,12-dioxo-5,6,7,8,9,10-hexahydro-8a,4b-(epoxyethano)phenanthrene-13-carboxylate
OXYC-018	1638678-46-2	((4bS,8aR,9S)-3-methoxy-4-(methoxymethoxy)-6,12-dioxo-5,6,7,8,9,10-hexahydro-8a,4b-(epoxyethano)phenanthren-9-yl)methyl acetate
OXYC-019	1638678-47-3	((4bS,8aR,9S)-4-hydroxy-3-methoxy-6,12-dioxo-5,6,7,8,9,10-hexahydro-8a,4b-(epoxyethano)phenanthren-9-yl)methyl acetate
OXYC-020	-	((4bR,8aR,9S)-5-bromo-4-hydroxy-3-methoxy-6,12-dioxo-5,6,7,8,9,10-hexahydro-8a,4b-(epoxyethano)phenanthren-9-yl)methyl acetate
OXYC-021	1638678-50-8	7a,9c-(Epoxyethano)phenanthro[4,5-bcd]furan-5,11(4aH)-dione, 8-[(acetyloxy)methyl]-6,7,8,9-tetrahydro-3-methoxy-, (4aR,7aR,8S,9cS)-
OXYC-022	1638678-51-9	7a,9c-(Epoxyethano)phenanthro[4,5-bcd]furan-5,11(4aH)-dione, 6,7,8,9-tetrahydro-8-(hydroxymethyl)-3-methoxy-, (4aR,7aR,8S,9cS)-
OXYC-023	1638678-52-0	7a,9c-(Epoxyethano)phenanthro[4,5-bcd]furan-8-carboxylic acid, 4a,5,6,7,8,9-hexahydro-3-methoxy-5,11-dioxo-, (4aR,7aR,8R,9cS)-
OXYC-024	1638678-53-1	7a,9c-(Epoxyethano)phenanthro[4,5-bcd]furan-8-carboxamide, 4a,5,6,7,8,9-hexahydro-3-methoxy-5,11-dioxo-, (4aR,7aR,8R,9cS)-
OXYC-025	1638678-54-2	(4R,4aS,7aR,12bS)-4a-hydroxy-9-methoxy-4,4a,5,6-tetrahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-2,7(3H,7aH)-dione
OXYC-026	-	(4R,4aS,7aR,12bS)-9-methoxy-3-methyl-1,2,3,4,5,6,7,7a-octahydro-4aH-4,12-methanobenzofuro[3,2-e]isoquinoline-4a,7-diol

常见问题（FAQ）

盐酸羟考酮的适应症有哪些？

已批准的适应症包括：疼痛、急性疼痛、慢性疼痛。

盐酸羟考酮的专利什么时候到期？

盐酸羟考酮的专利到期年暂无公开口径，本页会在数据管道核实后更新。

盐酸羟考酮有几条合成路线？

本站收录 2 条合成路线，最短路线 2 步、总收率 1.51 g (Oxycodone)。每条路线的中间体均带登记编号与 CAS 号。

盐酸羟考酮的关键中间体在哪里可以采购？

盐酸羟考酮路线中的中间体均已建立 CAS 档案，可直接按 CAS 发起询价，需求会进入供应网络撮合池。

如何获取盐酸羟考酮中间体的报价？

在本页选择目标中间体的 CAS 进入档案页，或在询价页直接提交需求；CAS 会自动带入供需撮合流程，由供应网络反馈报价。

数据来源：多源数据交叉核实（仅结构化字段） · 2026-09-27