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CAS 1638678-47-3
((4bS,8aR,9S)-4-hydroxy-3-methoxy-6,12-dioxo-5,6,7,8,9,10-hexahydro-8a,4b-(epoxyethano)phenanthren-9-yl)methyl acetate
登记编号：OXYC-019
应用背景（按来源药适应症）
疼痛盐酸纳洛酮/盐酸羟考酮不宁腿综合征盐酸纳洛酮/盐酸羟考酮癌症疼痛盐酸纳洛酮/盐酸羟考酮慢性疼痛盐酸纳洛酮/盐酸羟考酮骨关节炎盐酸纳洛酮/盐酸羟考酮腰痛盐酸纳洛酮/盐酸羟考酮疼痛盐酸羟考酮急性疼痛盐酸羟考酮慢性疼痛盐酸羟考酮术后疼痛盐酸羟考酮呼吸障碍盐酸羟考酮焦虑症盐酸羟考酮
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| 盐酸纳洛酮/盐酸羟考酮Naloxone Hydrochloride/Oxycodone Hydrochloride Hydrate | Tier C · 观察 / 贸易 | - |
| 盐酸羟考酮Oxycodone Hydrochloride Hydrate | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
2-bromo-3-hydroxy-4-methoxybenzaldehyde→2-bromo-4-methoxy-3-(methoxymethoxy)benzaldehyde→(2-bromo-4-methoxy-3-(methoxymethoxy)phenyl)methanol→2-bromo-1-(bromomethyl)-4-methoxy-3-(methoxymethoxy)benzene→(R)-4-benzyl-3-(2-(4-(benzyloxy)phenyl)acetyl)oxazolidin-2-one→(R)-4-benzyl-3-((R)-2-(4-(benzyloxy)-2-bromophenyl)-3-(4-methoxy-3-(methoxymethoxy)phenyl)propanoyl)oxazolidin-2-one→(R)-2-(4-(benzyloxy)-2-bromophenyl)-3-(4-methoxy-3-(methoxymethoxy)phenyl)propanoic acid→methyl (R)-2-(4-(benzyloxy)-2-bromophenyl)-3-(4-methoxy-3-(methoxymethoxy)phenyl)propanoate→methyl (R)-6-(benzyloxy)-3-methoxy-4-(methoxymethoxy)-9,10-dihydrophenanthrene-9-carboxylate→(R)-(6-hydroxy-3-methoxy-4-(methoxymethoxy)-9,10-dihydrophenanthren-9-yl)methyl acetate→((8aR,9S)-8a-hydroxy-3-methoxy-4-(methoxymethoxy)-6-oxo-6,8a,9,10-tetrahydrophenanthren-9-yl)methyl acetate→((8aR,9S)-8a-hydroxy-3-methoxy-4-(methoxymethoxy)-6-oxo-6,7,8,8a,9,10-hexahydrophenanthren-9-yl)methyl acetate→methyl 3-chloro-3-oxopropanoate→(8aR,9S)-9-(acetoxymethyl)-3-methoxy-4-(methoxymethoxy)-6-oxo-7,8,9,10-tetrahydrophenanthren-8a(6H)-yl methyl malonate→methyl (4bS,8aR,9S,13S)-9-(acetoxymethyl)-3-methoxy-4-(methoxymethoxy)-6,12-dioxo-5,6,7,8,9,10-hexahydro-8a,4b-(epoxyethano)phenanthrene-13-carboxylate→((4bS,8aR,9S)-3-methoxy-4-(methoxymethoxy)-6,12-dioxo-5,6,7,8,9,10-hexahydro-8a,4b-(epoxyethano)phenanthren-9-yl)methyl acetate→((4bS,8aR,9S)-4-hydroxy-3-methoxy-6,12-dioxo-5,6,7,8,9,10-hexahydro-8a,4b-(epoxyethano)phenanthren-9-yl)methyl acetate→((4bR,8aR,9S)-5-bromo-4-hydroxy-3-methoxy-6,12-dioxo-5,6,7,8,9,10-hexahydro-8a,4b-(epoxyethano)phenanthren-9-yl)methyl acetate→7a,9c-(Epoxyethano)phenanthro[4,5-bcd]furan-5,11(4aH)-dione, 8-[(acetyloxy)methyl]-6,7,8,9-tetrahydro-3-methoxy-, (4aR,7aR,8S,9cS)-→7a,9c-(Epoxyethano)phenanthro[4,5-bcd]furan-5,11(4aH)-dione, 6,7,8,9-tetrahydro-8-(hydroxymethyl)-3-methoxy-, (4aR,7aR,8S,9cS)-→7a,9c-(Epoxyethano)phenanthro[4,5-bcd]furan-8-carboxylic acid, 4a,5,6,7,8,9-hexahydro-3-methoxy-5,11-dioxo-, (4aR,7aR,8R,9cS)-→7a,9c-(Epoxyethano)phenanthro[4,5-bcd]furan-8-carboxamide, 4a,5,6,7,8,9-hexahydro-3-methoxy-5,11-dioxo-, (4aR,7aR,8R,9cS)-→(4R,4aS,7aR,12bS)-4a-hydroxy-9-methoxy-4,4a,5,6-tetrahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-2,7(3H,7aH)-dione→(4R,4aS,7aR,12bS)-9-methoxy-3-methyl-1,2,3,4,5,6,7,7a-octahydro-4aH-4,12-methanobenzofuro[3,2-e]isoquinoline-4a,7-diol
2-bromo-3-hydroxy-4-methoxybenzaldehyde→2-bromo-4-methoxy-3-(methoxymethoxy)benzaldehyde→(2-bromo-4-methoxy-3-(methoxymethoxy)phenyl)methanol→2-bromo-1-(bromomethyl)-4-methoxy-3-(methoxymethoxy)benzene→(R)-4-benzyl-3-(2-(4-(benzyloxy)phenyl)acetyl)oxazolidin-2-one→(R)-4-benzyl-3-((R)-2-(4-(benzyloxy)-2-bromophenyl)-3-(4-methoxy-3-(methoxymethoxy)phenyl)propanoyl)oxazolidin-2-one→(R)-2-(4-(benzyloxy)-2-bromophenyl)-3-(4-methoxy-3-(methoxymethoxy)phenyl)propanoic acid→methyl (R)-2-(4-(benzyloxy)-2-bromophenyl)-3-(4-methoxy-3-(methoxymethoxy)phenyl)propanoate→methyl (R)-6-(benzyloxy)-3-methoxy-4-(methoxymethoxy)-9,10-dihydrophenanthrene-9-carboxylate→(R)-(6-hydroxy-3-methoxy-4-(methoxymethoxy)-9,10-dihydrophenanthren-9-yl)methyl acetate→((8aR,9S)-8a-hydroxy-3-methoxy-4-(methoxymethoxy)-6-oxo-6,8a,9,10-tetrahydrophenanthren-9-yl)methyl acetate→((8aR,9S)-8a-hydroxy-3-methoxy-4-(methoxymethoxy)-6-oxo-6,7,8,8a,9,10-hexahydrophenanthren-9-yl)methyl acetate→methyl 3-chloro-3-oxopropanoate→(8aR,9S)-9-(acetoxymethyl)-3-methoxy-4-(methoxymethoxy)-6-oxo-7,8,9,10-tetrahydrophenanthren-8a(6H)-yl methyl malonate→methyl (4bS,8aR,9S,13S)-9-(acetoxymethyl)-3-methoxy-4-(methoxymethoxy)-6,12-dioxo-5,6,7,8,9,10-hexahydro-8a,4b-(epoxyethano)phenanthrene-13-carboxylate→((4bS,8aR,9S)-3-methoxy-4-(methoxymethoxy)-6,12-dioxo-5,6,7,8,9,10-hexahydro-8a,4b-(epoxyethano)phenanthren-9-yl)methyl acetate→((4bS,8aR,9S)-4-hydroxy-3-methoxy-6,12-dioxo-5,6,7,8,9,10-hexahydro-8a,4b-(epoxyethano)phenanthren-9-yl)methyl acetate→((4bR,8aR,9S)-5-bromo-4-hydroxy-3-methoxy-6,12-dioxo-5,6,7,8,9,10-hexahydro-8a,4b-(epoxyethano)phenanthren-9-yl)methyl acetate→7a,9c-(Epoxyethano)phenanthro[4,5-bcd]furan-5,11(4aH)-dione, 8-[(acetyloxy)methyl]-6,7,8,9-tetrahydro-3-methoxy-, (4aR,7aR,8S,9cS)-→7a,9c-(Epoxyethano)phenanthro[4,5-bcd]furan-5,11(4aH)-dione, 6,7,8,9-tetrahydro-8-(hydroxymethyl)-3-methoxy-, (4aR,7aR,8S,9cS)-→7a,9c-(Epoxyethano)phenanthro[4,5-bcd]furan-8-carboxylic acid, 4a,5,6,7,8,9-hexahydro-3-methoxy-5,11-dioxo-, (4aR,7aR,8R,9cS)-→7a,9c-(Epoxyethano)phenanthro[4,5-bcd]furan-8-carboxamide, 4a,5,6,7,8,9-hexahydro-3-methoxy-5,11-dioxo-, (4aR,7aR,8R,9cS)-→(4R,4aS,7aR,12bS)-4a-hydroxy-9-methoxy-4,4a,5,6-tetrahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-2,7(3H,7aH)-dione→(4R,4aS,7aR,12bS)-9-methoxy-3-methyl-1,2,3,4,5,6,7,7a-octahydro-4aH-4,12-methanobenzofuro[3,2-e]isoquinoline-4a,7-diol
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