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CAS 105-34-0

methyl 2-cyanoacetate2-Cyanoacetic acid methyl ester

登记编号:ROXA-015、Cefoselis Sulfate-011

应用背景(按来源药适应症)

贫血罗沙司他细菌感染硫酸头孢噻利

来源药(使用该中间体的合成路线)

品种梯队到期年
罗沙司他RoxadustatTier C · 观察 / 贸易2028
硫酸头孢噻利Cefoselis SulfateTier C · 观察 / 贸易-

合成路线中的位置(上下游链)

按路线登记顺序排列,左→右为合成方向;高亮为当前 CAS,其余可点击跳转对应档案。

硫酸头孢噻利优化路线步数:10总收率:231. 2g(Cefoselis Sulfate-001)
2-(5-Amino-1H-pyrazol-1-yl)ethan-1-ol→N,N-Dimethylformamide→2-Cyanoacetic acid methyl ester→2-Cyanoacetic acid ethyl ester→Propyl cyanoacetate→Butyl cyanoacetate→Methyl 2-cyano-3-(dimethylamino)prop-2-enoate→Ethyl 2-cyano-3-(dimethylamino)prop-2-enoate→Propyl 2-cyano-3-(dimethylamino)prop-2-enoate→Butyl 2-cyano-3-(dimethylamino)prop-2-enoate→2-Hydrazinoethanol→Methyl 5-amino-1-(2-hydroxyethyl)-1H-pyrazole-4-carboxylate→Ethyl 5-amino-1-(2-hydroxyethyl)-1H-pyrazole-4-carboxylate→Propyl 5-amino-1-(2-hydroxyethyl)-1H-pyrazole-4-carboxylate→Butyl 5-amino-1-(2-hydroxyethyl)-1H-pyrazole-4-carboxylate→5-Amino-1-(2-hydroxyethyl)-1H-pyrazole-4-carboxylic acid→Hex-3-enedinitrile→But-3-enenitrile→3-Oxopropanenitrile→3,3-Dimethoxypropanenitrile→3-[2-(2-Hydroxyethyl)hydrazinylidene]propanenitrile

本站可供应的对应中间体

同 CAS 多家在售供应横向对比;价格区间为供应方挂牌口径,实价以询价确认为准。

供应商产品价格区间最小起订货期资质
Unibest Taizhou GMP-like Site4-hydroxy-1-methyl-7-phenoxy-3-Isoquinolinecarboxylic acid
Pharmaceutical Intermediates
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Qualified Partner — East China API Works4-hydroxy-1-methyl-7-phenoxy-3-Isoquinolinecarboxylic acid
Pharmaceutical Intermediates
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Unibest Nantong cGMP SiteMethyl 4-hydroxy-7-phenoxyisoquinoline-3-carboxylate
Pharmaceutical Intermediates
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Unibest Taizhou GMP-like Site5-Phenoxyisobenzofuran-1(3H)-one
Pharmaceutical Intermediates
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Qualified Partner — East China API Works4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid ethyl ester
Pharmaceutical Intermediates
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Unibest Nantong cGMP Site4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester
Pharmaceutical Intermediates
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本页为中间体 CAS 注册档案:同 CAS 的多条路线登记已合并;后续供应商报价与买方需求以该 CAS 为主键撮合。