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CAS 160231-69-6
(S)-tetrahydrofuran-3-yl ((2S,3R)-3-hydroxy-4-(N-isobutyl-4-nitrophenylsulfonamido)-1-phenylbutan-2-yl)carbamate
登记编号：FOSAC-008
应用背景（按来源药适应症）
HIV感染福沙那韦钙
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| 福沙那韦钙Fosamprenavir Calcium | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
tert-butyl ((2S,3R)-3-hydroxy-4-(isobutylamino)-1-phenylbutan-2-yl)carbamate→benzyl ((2R,3S)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-4-phenylbutyl)(isobutyl)carbamate→benzyl ((2R,3S)-3-amino-2-hydroxy-4-phenylbutyl)(isobutyl)carbamate hydrochloride→(S)-2,5-dioxopyrrolidin-1-yl (tetrahydrofuran-3-yl) carbonate→benzyl ((2R,3S)-2-hydroxy-4-phenyl-3-(((((S)-tetrahydrofuran-3-yl)oxy)carbonyl)amino)butyl)(isobutyl)carbamate→(S)-tetrahydrofuran-3-yl ((2S,3R)-3-hydroxy-4-(isobutylamino)-1-phenylbutan-2-yl)carbamate→4-nitrobenzenesulfonyl chloride→(S)-tetrahydrofuran-3-yl ((2S,3R)-3-hydroxy-4-(N-isobutyl-4-nitrophenylsulfonamido)-1-phenylbutan-2-yl)carbamate
tert-butyl ((2S,3R)-3-hydroxy-4-(isobutylamino)-1-phenylbutan-2-yl)carbamate→4-nitrobenzenesulfonyl chloride→(S)-tetrahydrofuran-3-yl ((2S,3R)-3-hydroxy-4-(N-isobutyl-4-nitrophenylsulfonamido)-1-phenylbutan-2-yl)carbamate→L-phenylalanine→(S)-2-(dibenzylamino)-3-phenylpropanal→(2S,3S)-1-chloro-3-(dibenzylamino)-4-phenylbutan-2-ol hydrochloride→(2S,3S)-3-amino-1-chloro-4-phenylbutan-2-ol hydrochloride→tert-butyl ((S)-1-((S)-oxiran-2-yl)-2-phenylethyl)carbamate→N-((2R,3S)-3-amino-2-hydroxy-4-phenylbutyl)-N-isobutyl-4-nitrobenzenesulfonamide hydrochloride→(S)-tetrahydrofuran-3-yl 1H-imidazole-1-carboxylate→(S)-tetrahydrofuran-3-yl ((2S,3R)-4-((N-isobutyl-4-nitrophenyl)sulfonamido)-1-phenyl-3-(phosphonooxy)butan-2-yl)carbamate→(S)-tetrahydrofuran-3-yl ((2S,3R)-4-((4-amino-N-isobutylphenyl)sulfonamido)-1-phenyl-3-(phosphonooxy)butan-2-yl)carbamate
(S)-tetrahydrofuran-3-yl ((2S,3R)-3-hydroxy-4-(N-isobutyl-4-nitrophenylsulfonamido)-1-phenylbutan-2-yl)carbamate→(S)-tetrahydrofuran-3-yl ((2S,3R)-4-((N-isobutyl-4-nitrophenyl)sulfonamido)-1-phenyl-3-(phosphonooxy)butan-2-yl)carbamate→(S)-tetrahydrofuran-3-yl ((2S,3R)-4-((4-amino-N-isobutylphenyl)sulfonamido)-1-phenyl-3-(phosphonooxy)butan-2-yl)carbamate
4-nitrobenzenesulfonyl chloride→(S)-tetrahydrofuran-3-yl ((2S,3R)-3-hydroxy-4-(N-isobutyl-4-nitrophenylsulfonamido)-1-phenylbutan-2-yl)carbamate→(E)-4-phenylbut-2-en-1-ol→(3-benzyloxiran-2-yl)methanol→3-azido-4-phenylbutane-1,2-diol→2-(1-azido-2-phenylethyl)oxirane→Cobalt, [[2,2'-[(1S,2S)-1,2-cyclohexanediylbis[(nitrilo-kN)methylidyne]]bis[4,6-bis(1,1-dimethylethyl)phenolato-kO]](2-)]-, (SP-4-2)-→(S)-2-((S)-1-azido-2-phenylethyl)oxirane→(2R,3S)-3-azido-1-(isobutylamino)-4-phenylbutan-2-ol→N-((2R,3S)-3-azido-2-hydroxy-4-phenylbutyl)-N-isobutyl-4-nitrobenzenesulfonamide→(S)-tetrahydrofuran-3-yl 2,5-dioxopyrrolidine-1-carboxylate→(S)-tetrahydrofuran-3-yl ((2S,3R)-4-((4-amino-N-isobutylphenyl)sulfonamido)-3-hydroxy-1-phenylbutan-2-yl)carbamate
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