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CAS 1616760-96-3
2-chloro-N-methyl-N-((3R,4R)-4-methyl-1-tritylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
登记编号：TOFA-026
应用背景（按来源药适应症）
强直性脊柱炎枸橼酸托法替布幼年型类风湿性关节炎枸橼酸托法替布溃疡性结肠炎枸橼酸托法替布银屑病关节炎枸橼酸托法替布类风湿关节炎枸橼酸托法替布
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| 枸橼酸托法替布Tofacitinib Citrate | Tier B · 提前布局 | 2028 |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
methyl (4-methylpyridin-3-yl)carbamate→4-methylpyridin-3-amine→methyl (4-methylpiperidin-3-yl)carbamate→methyl (4-methyl-1-tritylpiperidin-3-yl)carbamate→N,4-dimethyl-1-tritylpiperidin-3-amine hydrochloride→(3R,4R)-N,4-dimethyl-1-tritylpiperidin-3-amine (2R,3R)-2,3-bis((4-methylbenzoyl)oxy)succinate→(3R,4R)-N,4-dimethyl-1-tritylpiperidin-3-amine→2,4-dichloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine→2-chloro-N-methyl-N-((3R,4R)-4-methyl-1-tritylpiperidin-3-yl)-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine→2-chloro-N-methyl-N-((3R,4R)-4-methyl-1-tritylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine→2-chloro-N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine→2-cyanoacetic acid
本站可供应的对应中间体
同 CAS 多家在售供应横向对比；价格区间为供应方挂牌口径，实价以询价确认为准。
| 供应商 | 产品 | 价格区间 | 最小起订 | 货期 | 资质 |
|---|---|---|---|---|---|
| Unibest Nantong cGMP Site | （3R,4R)-N,4-Dimethyl-1-(phenylmethyl)-3-piperidinamine HCL Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Unibest Taizhou GMP-like Site | 4-Chloro-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidine Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Qualified Partner — East China API Works | 1-benzyl-4-methylpiperidin-3-one Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Unibest Nantong cGMP Site | N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
本页为中间体 CAS 注册档案：同 CAS 的多条路线登记已合并；后续供应商报价与买方需求以该 CAS 为主键撮合。