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盐酸可乐定 (Tris Pharma)

Tier C — Watch / trade

Clonidine Hydrochloride (Tris Pharma)

Tris Pharma Inc
Originator
2009
First approval
-
Expiry (public)
No sales data
Peak sales
化学药
Type

Targets：ADRA2、Imidazoline receptor

Brand：Nexiclon XR、Onyda XR、ONYDA XR

Indications (approved)：注意力缺陷障碍伴多动、高血压

Regional status

US
批准上市
2009-12-03
EU
-
China
-
Japan
-

Synthetic routes & intermediates5 routes

Originator routes × 0Optimised (non-patent) × 5Process routes × 0

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OptimisedRoute 1Steps 3 · Total yield /
Synthetic routes & intermediates Route 1
CodeCAS No.Intermediate
(I)122568-1-a608-31-12,6-Dichloroaniline
(IIa)122568-1-a6590-91-6(2,6-dichlorophenyl)thiourea
(IIb)122568-1-a41542-10-3N-[(2,6-Dichlorophenyl)carbamothioyl]benzamide
(III)122568-1-a27806-88-8Methyl N-(2,6-dichlorophenyl)carbamimidothioate hydrogen iodide
(IV)122568-1-a107-15-31,2-Diaminoethane
OptimisedRoute 2Steps 2 · Total yield /
Synthetic routes & intermediates Route 2
CodeCAS No.Intermediate
(I)122568-2-a6590-95-01,3-Dichloro-2-isothiocyanatobenzene
(II)122568-2-a107-15-31,2-Diaminoethane
(III)122568-2-a65295-68-33-(2-aminoethyl)-1-(2,6-dichlorophenyl)thiourea
OptimisedRoute 3Steps 4 · Total yield /
Synthetic routes & intermediates Route 3
CodeCAS No.Intermediate
(I)122568-3-a88-73-31-Chloro-2-nitrobenzene
(II)122568-3-a10468-16-3N-(2-chlorophenyl)hydroxylamine
(III)122568-3-a64-18-6Formic acid
(IV)122568-3-a109384-39-6N-(2-Chlorophenyl)-N-hydroxyformamide
(VI)122568-3-a608-31-12,6-Dichloroaniline
(VII)122568-3-a10113-35-6N-(2,6-Dichlorophenyl)formamide
(VIII)122568-3-a107-15-31,2-Diaminoethane
OptimisedRoute 4Steps 2 · Total yield /
Synthetic routes & intermediates Route 4
CodeCAS No.Intermediate
(I)122568-4-a96-45-72-Mercaptoimidazoline
(II)122568-4-a64205-92-14,5-Dihydro-1H-imidazole-2-sulfonic acid
(III)122568-4-a608-31-12,6-Dichloroaniline
OptimisedRoute 5Steps 3 · Total yield /
Synthetic routes & intermediates Route 5
CodeCAS No.Intermediate
(I)122568-5-a96-45-72-Mercaptoimidazoline
(II)122568-5-a5292-43-31,1-Dimethylethyl monobromoacetate
(III)122568-5-a-tert-Butyl [(4,5-dihydro-1H-imidazol-2-yl)sulfanyl]acetate hydrogen bromide
(IV)122568-5-a2891462-25-0Methyl 2-[(2-tert-butoxy-2-oxoethyl)sulfanyl]-4,5-dihydro-1H-imidazole-1-carboxylate
(V)122568-5-a608-31-12,6-Dichloroaniline

Frequently asked questions

What are the approved indications of Clonidine Hydrochloride (Tris Pharma)?

Approved indications include: 注意力缺陷障碍伴多动, 高血压.

When does the Clonidine Hydrochloride (Tris Pharma) patent expire?

No public expiry year is available for Clonidine Hydrochloride (Tris Pharma) yet; this page updates once verified.

How many synthesis routes are recorded for Clonidine Hydrochloride (Tris Pharma)?

5 synthesis routes are recorded; the shortest is 2 steps with / total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Clonidine Hydrochloride (Tris Pharma) intermediates?

All intermediates in Clonidine Hydrochloride (Tris Pharma) routes have CAS profiles — you can submit an RFQ per CAS and it enters the Unibest matching pool.

How do I get a quote for Clonidine Hydrochloride (Tris Pharma) intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-24