CAS 107-15-3

ethane-1,2-diamine1,2-Diaminoethane

Codes：PEGL-006、(IV)122568-1-a、(II)122568-2-a、(VIII)122568-3-a

Application context (from source-drug indications)

二型糖尿病聚乙二醇洛塞那肽肥胖症聚乙二醇洛塞那肽子宫内膜增生聚乙二醇洛塞那肽注意力缺陷障碍伴多动盐酸可乐定 (Tris Pharma)高血压盐酸可乐定 (Tris Pharma)

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
聚乙二醇洛塞那肽PEG-Loxenatide	Tier C — Watch / trade	-
盐酸可乐定 (Tris Pharma)Clonidine Hydrochloride (Tris Pharma)	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

聚乙二醇洛塞那肽原研路线steps: 7total yield: 4.50 g (PEG-Loxenatide)

2-(2-methoxyethoxy)ethan-1-ol→2-(2-methoxyethoxy)ethyl carbonochloridate→2,5-dioxopyrrolidin-1-yl (2-(2-methoxyethoxy)ethyl) carbonate→15-(((2-(2-methoxyethoxy)ethoxy)carbonyl)amino)-9-oxo-2,5,8-trioxa-10-azahexadecan-16-oic acid→2,5-dioxopyrrolidin-1-yl 15-(((2-(2-methoxyethoxy)ethoxy)carbonyl)amino)-9-oxo-2,5,8-trioxa-10-azahexadecan-16-oate→ethane-1,2-diamine→bis(2-(2-methoxyethoxy)ethyl) (6-((2-aminoethyl)amino)-6-oxohexane-1,5-diyl)dicarbamate→4-nitrophenyl 3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanoate→bis(2-(2-methoxyethoxy)ethyl) (6-((2-(3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanamido)ethyl)amino)-6-oxohexane-1,5-diyl)dicarbamate

盐酸可乐定 (Tris Pharma)优化路线steps: 3total yield: /

2,6-Dichloroaniline→(2,6-dichlorophenyl)thiourea→N-[(2,6-Dichlorophenyl)carbamothioyl]benzamide→Methyl N-(2,6-dichlorophenyl)carbamimidothioate hydrogen iodide→1,2-Diaminoethane

盐酸可乐定 (Tris Pharma)优化路线steps: 2total yield: /

1,3-Dichloro-2-isothiocyanatobenzene→1,2-Diaminoethane→3-(2-aminoethyl)-1-(2,6-dichlorophenyl)thiourea

盐酸可乐定 (Tris Pharma)优化路线steps: 4total yield: /

1-Chloro-2-nitrobenzene→N-(2-chlorophenyl)hydroxylamine→Formic acid→N-(2-Chlorophenyl)-N-hydroxyformamide→2,6-Dichloroaniline→N-(2,6-Dichlorophenyl)formamide→1,2-Diaminoethane

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