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盐酸鲁拉西酮

Tier B — Position early

Lurasidone Hydrochloride · all drugs expiring in 2028 →

大日本住友
Originator
2010
First approval
2028
Expiry (public)
$1.95B ▲
Peak sales
化学药
Type

Targets：5-HT7、5-HT2A、5-HT1A、DRD2

Brand：罗舒达、Latuda

Indications (approved)：重度抑郁症、精神分裂症、躁狂症、抑郁症

Regional status

US
批准上市
2010-10-28
EU
批准上市
2014-03-20
China
批准上市
2019-01-24
Japan
批准上市
2020-03-25

Synthetic routes & intermediates6 routes

Originator routes × 1Optimised (non-patent) × 4Process routes × 1

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OriginatorRoute 1Steps 4 · Total yield /
Synthetic routes & intermediates Route 1
CodeCAS No.Intermediate
LURA-00487691-87-03-(piperazin-1-yl)benzo[d]isothiazole
LURA-005-(3aR,7aR)-4'-(benzo[d]isothiazol-3-yl)octahydrospiro[isoindole-2,1'-piperazin]-2-ium methanesulfonate
LURA-0062054161-88-3(3aR,4S,7R,7aS)-hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dione
LURA-00171749-03-6(3aR,7aR)-hexahydroisobenzofuran-1,3-dione
LURA-00265376-05-8Available((1R,2R)-cyclohexane-1,2-diyl)dimethanol
LURA-003186204-35-3Available((1R,2R)-cyclohexane-1,2-diyl)bis(methylene) dimethanesulfonate
OptimisedRoute 2Steps 4 · Total yield /
Synthetic routes & intermediates Route 2
CodeCAS No.Intermediate
LURA-007110-17-8Availablefumaric acid
LURA-00877-79-22,5-dihydrothiophene 1,1-dioxide
LURA-00988-98-2cyclohex-4-ene-1,2-dicarboxylic acid
LURA-0101687-30-5cyclohexane-1,2-dicarboxylic acid
LURA-01158574-95-1(R)-1-phenylethan-1-aminium (1R,2S)-2-carboxycyclohexane-1-carboxylate
LURA-0122305-32-0(1R,2S)-cyclohexane-1,2-dicarboxylic acid
OptimisedRoute 3Steps 3 · Total yield /
Synthetic routes & intermediates Route 3
CodeCAS No.Intermediate
LURA-00487691-87-03-(piperazin-1-yl)benzo[d]isothiazole
LURA-0131421374-92-6((1R,2R)-2-(aminomethyl)cyclohexyl)methanol
LURA-0141792220-25-7(3aR,4S,7R,7aS)-hexahydro-4,7-methanoisobenzofuran-1,3-dione
LURA-0151421374-93-7(3aR,4S,7R,7aS)-2-(((1R,2R)-2-(hydroxymethyl)cyclohexyl)methyl)hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dione
LURA-0161421374-94-8((1R,2R)-2-(((3aR,4S,7R,7aS)-1,3-dioxooctahydro-2H-4,7-methanoisoindol-2-yl)methyl)cyclohexyl)methyl methanesulfonate
OptimisedRoute 4Steps 5 · Total yield /
Synthetic routes & intermediates Route 4
CodeCAS No.Intermediate
LURA-0062054161-88-3(3aR,4S,7R,7aS)-hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dione
LURA-017186204-35-3Available((1R,2R)-cyclohexane-1,2-diyl)bis(methylene) dimethanesulfonate
LURA-018111-42-22,2'-azanediylbis(ethan-1-ol)
LURA-019-((1R,2R)-2-((bis(2-hydroxyethyl)amino)methyl)cyclohexyl)methyl methanesulfonate
LURA-0201421374-97-1(3aR,4S,7R,7aS)-2-(((1R,2R)-2-((bis(2-hydroxyethyl)amino)methyl)cyclohexyl)methyl)hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dione
LURA-0211421374-98-2((((1R,2R)-2-(((3aR,4S,7R,7aS)-1,3-dioxooctahydro-2H-4,7-methanoisoindol-2-yl)methyl)cyclohexyl)methyl)azanediyl)bis(ethane-2,1-diyl) dimethanesulfonate
LURA-02223031-78-9benzo[d]isothiazol-3-amine
OptimisedRoute 5Steps 3 · Total yield 4.5 g
Synthetic routes & intermediates Route 5
CodeCAS No.Intermediate
LURA-00487691-87-03-(piperazin-1-yl)benzo[d]isothiazole
LURA-005-(3aR,7aR)-4'-(benzo[d]isothiazol-3-yl)octahydrospiro[isoindole-2,1'-piperazin]-2-ium methanesulfonate
LURA-0062054161-88-3(3aR,4S,7R,7aS)-hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dione
LURA-017186204-35-3Available((1R,2R)-cyclohexane-1,2-diyl)bis(methylene) dimethanesulfonate
ProcessRoute 6Steps 1 · Total yield 4.5 g (Lurasidone)
Synthetic routes & intermediates Route 6
CodeCAS No.Intermediate
LURA-02414805-29-9Availableexo-Hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dioneexo-Norbornane-2,3-dicarboximide
LURA-023-[(1R,2R)-2-[[4-(1,2-Benzothiazol-3-yl)piperazin-1-yl]methyl]cyclohexyl]methyl methanesulfonate

Frequently asked questions

What are the approved indications of Lurasidone Hydrochloride?

Approved indications include: 重度抑郁症, 精神分裂症, 躁狂症, 抑郁症.

When does the Lurasidone Hydrochloride patent expire?

Based on public sources, the Lurasidone Hydrochloride patent expires in 2028.

How many synthesis routes are recorded for Lurasidone Hydrochloride?

6 synthesis routes are recorded; the shortest is 1 steps with 4.5 g (Lurasidone) total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Lurasidone Hydrochloride intermediates?

4 intermediate CAS of Lurasidone Hydrochloride are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.

How do I get a quote for Lurasidone Hydrochloride intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-24