Esomeprazole Magnesium Hydrate

Tier C — Watch / trade

AstraZeneca

Originator

2000

First approval

Expiry (public)

No sales data

Peak sales

Small molecule

Type

Targets：Proton pump

Brand：Nexium, Nexium 24HR

Indications (approved)：Heartburn, Gastro-oesophageal reflux disease, Duodenal ulcer, Gastric ulcer, Peptic oesophagitis, Helicobacter pylori infection, Zollinger-Ellison syndrome, Oesophagitis

Regional status

Approved

2001-02-20

Approved

2000-03-13

China

Approved

2002-10-16

Japan

Approved

2011-07-01

Factories producing this API2

Factories registered as producing this API in our sourcing network (RFQ records + product master), sorted by RFQ activity; the snapshot carries no cost or customer data.

2 producing factories on file — sign in to view the named list (factory details are not shown to guests).

Synthetic routes & intermediates5 routes

Originator routes × 0Optimised (non-patent) × 5Process routes × 0

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OptimisedRoute 1Steps 6 · Total yield 418.00 mg

ESOME-00186604-78-6ESOME-00284006-10-0ESOME-00337052-78-1ESOME-00473590-85-9ESOME-00573590-58-6ESOME-006119141-88-7ESOME-007161796-78-7API · Esomeprazole Magnesium Hydrate

Code	CAS No.	Intermediate
ESOME-001	86604-78-6	(4-methoxy-3,5-dimethylpyridin-2-yl)methanol
ESOME-002	84006-10-0	2-(chloromethyl)-4-methoxy-3,5-dimethylpyridine
ESOME-003	37052-78-1	5-methoxy-1H-benzo[d]imidazole-2-thiol
ESOME-004	73590-85-9	5-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)thio)-1H-benzo[d]imidazole
ESOME-005	73590-58-6	5-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)-1H-benzo[d]imidazole
ESOME-006	119141-88-7	(S)-5-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)-1H-benzo[d]imidazole
ESOME-007	161796-78-7	sodium (S)-5-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide

OptimisedRoute 2Steps 5 · Total yield 18.00 g

ESOME-00573590-58-6ESOME-006119141-88-7ESOME-00895510-70-6ESOME-00913811-71-7ESOME-010—ESOME-0111429047-64-2API · Esomeprazole Magnesium Hydrate

Code	CAS No.	Intermediate
ESOME-005	73590-58-6	5-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)-1H-benzo[d]imidazole
ESOME-006	119141-88-7	(S)-5-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)-1H-benzo[d]imidazole
ESOME-008	95510-70-6	sodium 5-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide
ESOME-009	13811-71-7	diethyl (2S,3S)-2,3-dihydroxysuccinate
ESOME-010	-	sodium (R)-5-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)(methyl)(oxo)-l5-sulfanyl)benzo[d]imidazol-1-ide
ESOME-011	1429047-64-2	-

OptimisedRoute 3Steps 6 · Total yield 1.35 g

ESOME-00573590-58-6ESOME-006119141-88-7ESOME-012118293-34-8ESOME-013118293-26-8ESOME-014611-71-2ESOME-015—ESOME-016161796-87-8API · Esomeprazole Magnesium Hydrate

Code	CAS No.	Intermediate
ESOME-005	73590-58-6	5-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)-1H-benzo[d]imidazole
ESOME-006	119141-88-7	(S)-5-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)-1H-benzo[d]imidazole
ESOME-012	118293-34-8	(6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)-1H-benzo[d]imidazol-1-yl)methanol
ESOME-013	118293-26-8	1-(chloromethyl)-6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)-1H-benzo[d]imidazole
ESOME-014	611-71-2	(R)-2-hydroxy-2-phenylacetic acid
ESOME-015	-	(6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)-1H-benzo[d]imidazol-1-yl)methyl (2R)-2-hydroxy-2-phenylacetate
ESOME-016	161796-87-8	(6-methoxy-2-((S)-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)-1H-benzo[d]imidazol-1-yl)methyl (R)-2-hydroxy-2-phenylacetate

OptimisedRoute 4Steps 3 · Total yield 31.60 g

ESOME-00573590-58-6ESOME-007161796-78-7ESOME-01718531-99-2ESOME-018—ESOME-019108-21-4API · Esomeprazole Magnesium Hydrate

Code	CAS No.	Intermediate
ESOME-005	73590-58-6	5-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)-1H-benzo[d]imidazole
ESOME-007	161796-78-7	sodium (S)-5-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide
ESOME-017	18531-99-2	[1,1'-binaphthalene]-2,2'-diol
ESOME-018	-	[1,1'-binaphthalene]-2,2'-diol compound with 5-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)-1H-benzo[d]imidazole (1:1)
ESOME-019	108-21-4	isopropyl acetate

OptimisedRoute 5Steps 1 · Total yield /

ESOME-00473590-85-9ESOME-00913811-71-7API · Esomeprazole Magnesium Hydrate

Code	CAS No.	Intermediate
ESOME-004	73590-85-9	5-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)thio)-1H-benzo[d]imidazole
ESOME-009	13811-71-7	diethyl (2S,3S)-2,3-dihydroxysuccinate

Frequently asked questions

What are the approved indications of Esomeprazole Magnesium Hydrate?

Approved indications include: Heartburn, Gastro-oesophageal reflux disease, Duodenal ulcer, Gastric ulcer, Peptic oesophagitis, Helicobacter pylori infection, Zollinger-Ellison syndrome, Oesophagitis.

When does the Esomeprazole Magnesium Hydrate patent expire?

No public expiry year is available for Esomeprazole Magnesium Hydrate yet; this page updates once verified.

How many synthesis routes are recorded for Esomeprazole Magnesium Hydrate?

5 synthesis routes are recorded; the shortest is 1 steps with / total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Esomeprazole Magnesium Hydrate intermediates?

All intermediates in Esomeprazole Magnesium Hydrate routes have CAS profiles — you can submit an RFQ per CAS and it enters the Unibest matching pool.

How do I get a quote for Esomeprazole Magnesium Hydrate intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-27