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Tier C — Watch / tradeBrivaracetam · all drugs expiring in 2028 →
Targets：SV2A
Brand：Briviact、Brivlera、Rikelta
Indications (approved)：癫痫部分性发作、癫痫、癫痫发作
Regional status
Synthetic routes & intermediates3 routes
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
| Code | CAS No. | Intermediate |
|---|---|---|
| BRIV-001 | 110-62-3Available | pentanal |
| BRIV-002 | 298-12-4Available | 2-oxoacetic acid |
| BRIV-003 | 52944-53-3Available | morpholine hydrochloride |
| BRIV-004 | 78920-10-2Available | 5-hydroxy-4-propylfuran-2(5H)-one |
| BRIV-005 | 7324-11-0Available | (S)-2-aminobutanamide |
| BRIV-006 | 357338-13-7Available | (S)-2-(2-oxo-4-propyl-2,5-dihydro-1H-pyrrol-1-yl)butanamide |
| BRIV-007 | 357336-19-7Available | (S)-2-((S)-2-oxo-4-propylpyrrolidin-1-yl)butanamide |
| BRIV-008 | 357336-20-0Available | (S)-2-((R)-2-oxo-4-propylpyrrolidin-1-yl)butanamide |
| Code | CAS No. | Intermediate |
|---|---|---|
| BRIV-008 | 357336-20-0Available | (S)-2-((R)-2-oxo-4-propylpyrrolidin-1-yl)butanamide |
| BRIV-009 | 1552-67-6Available | (E)-ethyl hex-2-enoate |
| BRIV-010 | 128013-61-6Available | ethyl 3-(nitromethyl)hexanoate |
| BRIV-011 | 89895-19-2Available | 4-propylpyrrolidin-2-one |
| BRIV-012 | 930123-37-8Available | (R)-4-propylpyrrolidin-2-one |
| BRIV-013 | 3196-15-4Available | methyl 2-bromobutanoate |
| BRIV-014 | - | (R)-methyl 2-((R)-2-oxo-4-propylpyrrolidin-1-yl)butanoate |
| BRIV-015 | 2052297-80-8Available | (S)-methyl 2-((R)-2-oxo-4-propylpyrrolidin-1-yl)butanoate |
| BRIV-016 | 357337-00-9Available | (R)-2-((R)-2-oxo-4-propylpyrrolidin-1-yl)butanamide |
| Code | CAS No. | Intermediate |
|---|---|---|
| BRIV-005 | 7324-11-0Available | (S)-2-aminobutanamide |
| BRIV-008 | 357336-20-0Available | (S)-2-((R)-2-oxo-4-propylpyrrolidin-1-yl)butanamide |
| BRIV-017 | 109-67-1Available | pent-1-ene |
| BRIV-018 | 108340-61-0Available | (R)-pentane-1,2-diol |
| BRIV-019 | - | (4R)-4-propyl-1,3,2-dioxathiolane 2-oxide |
| BRIV-020 | 941290-02-4Available | (R)-4-propyl-1,3,2-dioxathiolane 2,2-dioxide |
| BRIV-021 | 108-59-8Available | dimethyl malonate |
| BRIV-022 | 851293-04-4Available | (R)-dimethyl 2-propylcyclopropane-1,1-dicarboxylate |
| BRIV-023 | - | (R)-2-propylcyclopropane-1,1-dicarboxylic acid |
| BRIV-024 | 851292-98-3Available | (R)-6,6-dimethyl-1-propyl-5,7-dioxaspiro[2.5]octane-4,8-dione |
| BRIV-025 | 941289-95-8Available | (4R)-1-((S)-1-amino-1-oxobutan-2-yl)-2-oxo-4-propylpyrrolidine-3-carboxylic acid |
| BRIV-026 | 941290-06-8Available | 1-((S)-1-amino-1-oxobutan-2-yl)-2-oxo-5-propylpyrrolidine-3-carboxylic acid |
| BRIV-027 | 941289-99-2Available | (4R)-methyl 1-((S)-1-amino-1-oxobutan-2-yl)-2-oxo-4-propylpyrrolidine-3-carboxylate |
| BRIV-028 | 941290-08-0Available | methyl 1-((S)-1-amino-1-oxobutan-2-yl)-2-oxo-5-propylpyrrolidine-3-carboxylate |
| BRIV-029 | 1822298-86-1Available | (2S)-2-(2-oxo-5-propylpyrrolidin-1-yl)butanamide |
Frequently asked questions
What are the approved indications of Brivaracetam?
Approved indications include: 癫痫部分性发作, 癫痫, 癫痫发作.
When does the Brivaracetam patent expire?
Based on public sources, the Brivaracetam patent expires in 2028.
How many synthesis routes are recorded for Brivaracetam?
3 synthesis routes are recorded; the shortest is 4 steps with 7.2 g total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Brivaracetam intermediates?
26 intermediate CAS of Brivaracetam are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Brivaracetam intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-24