CAS 298-12-4

2-oxoacetic acid

Codes：BRIV-002、TELAP-041、VILD-020

Application context (from source-drug indications)

癫痫部分性发作布瓦西坦癫痫布瓦西坦癫痫发作布瓦西坦丙型肝炎特拉匹韦慢性丙型肝炎特拉匹韦HIV感染特拉匹韦肝功能衰退特拉匹韦阿片类依赖特拉匹韦肾脏疾病特拉匹韦二型糖尿病维格列汀精神分裂症维格列汀血脂障碍维格列汀胰岛素抵抗维格列汀一型糖尿病维格列汀糖尿病维格列汀

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
布瓦西坦Brivaracetam	Tier C — Watch / trade	2028
特拉匹韦Telaprevir	Tier B — Position early	-
维格列汀Vildagliptin	Tier B — Position early	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

布瓦西坦原研路线steps: 4total yield: 7.2 g

pentanal→2-oxoacetic acid→morpholine hydrochloride→5-hydroxy-4-propylfuran-2(5H)-one→(S)-2-aminobutanamide→(S)-2-(2-oxo-4-propyl-2,5-dihydro-1H-pyrrol-1-yl)butanamide→(S)-2-((S)-2-oxo-4-propylpyrrolidin-1-yl)butanamide→(S)-2-((R)-2-oxo-4-propylpyrrolidin-1-yl)butanamide

特拉匹韦优化路线steps: 12total yield: 6.28 g

pyrazine-2-carboxylic acid→cyclopropanamine→1-nitrobutane→2-oxoacetic acid→(3S)-2-hydroxy-3-nitrohexanoic acid→(3S)-3-amino-2-hydroxyhexanoic acid→(3S)-3-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-2-hydroxyhexanoic acid→(S)-3-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-2-oxohexanoic acid→TELAP-046→TELAP-047→(1S,3aR,6aS)-2-(((9H-fluoren-9-yl)methoxy)carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxylic acid→TELAP-049→(S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3,3-dimethylbutanoic acid→TELAP-051→(S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-2-cyclohexylacetic acid→TELAP-053→TELAP-054→(S)-3-((1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)octahydrocyclopenta[c]pyrrole-1-carboxamido)-2-oxohexanoic acid

维格列汀优化路线steps: 4total yield: /

(1s,3r,5R,7S)-3-aminoadamantan-1-ol→(3s,5s,7s)-adamantan-1-amine hydrochloride→((1r,3s,5R,7S)-3-hydroxyadamantan-1-yl)glycine→(S)-pyrrolidine-2-carbonitrile→2-oxoacetic acid→(E)-2-(((1r,3s,5R,7S)-3-hydroxyadamantan-1-yl)imino)acetic acid

维格列汀优化路线steps: 5total yield: 72 g

(S)-pyrrolidine-2-carboxamide→(1s,3r,5R,7S)-3-aminoadamantan-1-ol→2-oxoacetic acid→N-formyl-N-((1r,3s,5R,7S)-3-hydroxyadamantan-1-yl)glycine→(S)-1-(N-formyl-N-((1r,3R,5R,7S)-3-hydroxyadamantan-1-yl)glycyl)pyrrolidine-2-carboxamide→(1R,3r,5R,7S)-3-(N-(2-((S)-2-cyanopyrrolidin-1-yl)-2-oxoethyl)formamido)adamantan-1-yl 2,2,2-trifluoroacetate→N-(2-((S)-2-cyanopyrrolidin-1-yl)-2-oxoethyl)-N-((1r,3R,5R,7S)-3-hydroxyadamantan-1-yl)formamide

Intermediates available on this site

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Supplier	Product	Price band	MOQ	Lead time	Qualifications
Unibest Taizhou GMP-like Site	Brivaracetam Pharmaceutical Intermediates	询价	询价	询价	—
Qualified Partner — East China API Works	(+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one Pharmaceutical Intermediates	询价	询价	询价	—

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