盐酸埃克替尼
Tier C — Watch / tradeIcotinib Hydrochloride
Targets：EGFR
Brand：Conmana、凯美纳
Indications (approved)：非小细胞肺癌
Regional status
Synthetic routes & intermediates4 routes
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
| Code | CAS No. | Intermediate |
|---|---|---|
| ICOT-002 | 19249-03-7 | (ethane-1,2-diylbis(oxy))bis(ethane-2,1-diyl) bis(4-methylbenzenesulfonate) |
| ICOT-010 | 5653-40-7 | 2-amino-4,5-dimethoxybenzoic acid |
| ICOT-011 | 13794-72-4Available | 6,7-dimethoxyquinazolin-4(3H)-one |
| ICOT-012 | 13790-39-1Available | 4-chloro-6,7-dimethoxyquinazoline |
| ICOT-013 | 591-19-5 | 3-bromoaniline |
| ICOT-014 | 153436-54-5 | N-(3-bromophenyl)-6,7-dimethoxyquinazolin-4-amine |
| ICOT-015 | - | 4-((3-bromophenyl)amino)quinazoline-6,7-diol hydrochloride |
| ICOT-016 | 610798-18-0 | N-(3-bromophenyl)-7,8,10,11,13,14-hexahydro-[1,4,7,10]tetraoxacyclododecino[2,3-g]quinazolin-4-amine |
| ICOT-017 | 1066-54-2 | ethynyltrimethylsilane |
| Code | CAS No. | Intermediate |
|---|---|---|
| ICOT-001 | 112-27-6 | 2,2'-(ethane-1,2-diylbis(oxy))bis(ethan-1-ol) |
| ICOT-002 | 19249-03-7 | (ethane-1,2-diylbis(oxy))bis(ethane-2,1-diyl) bis(4-methylbenzenesulfonate) |
| ICOT-003 | 3943-89-3 | ethyl 3,4-dihydroxybenzoate |
| ICOT-004 | 180475-66-5 | ethyl 2,3,5,6,8,9-hexahydrobenzo[b][1,4,7,10]tetraoxacyclododecine-12-carboxylate |
| ICOT-005 | 1204313-55-2 | ethyl 13-nitro-2,3,5,6,8,9-hexahydrobenzo[b][1,4,7,10]tetraoxacyclododecine-12-carboxylate |
| ICOT-006 | 1204313-56-3 | ethyl 13-amino-2,3,5,6,8,9-hexahydrobenzo[b][1,4,7,10]tetraoxacyclododecine-12-carboxylate hydrochloride |
| ICOT-007 | 1204313-57-4 | 7,8,10,11,13,14-hexahydro-[1,4,7,10]tetraoxacyclododecino[2,3-g]quinazolin-4(3H)-one |
| ICOT-008 | 1204313-58-5 | 4-chloro-7,8,10,11,13,14-hexahydro-[1,4,7,10]tetraoxacyclododecino[2,3-g]quinazoline |
| ICOT-009 | 54060-30-9Available | 3-ethynylaniline |
| Code | CAS No. | Intermediate |
|---|---|---|
| ICOT-002 | 19249-03-7 | (ethane-1,2-diylbis(oxy))bis(ethane-2,1-diyl) bis(4-methylbenzenesulfonate) |
| ICOT-009 | 54060-30-9Available | 3-ethynylaniline |
| ICOT-018 | 17345-61-8 | 3,4-dihydroxybenzonitrile |
| ICOT-019 | 352017-90-4 | 2,3,5,6,8,9-hexahydrobenzo[b][1,4,7,10]tetraoxacyclododecine-12-carbonitrile |
| ICOT-020 | 1432922-22-9 | 13-nitro-2,3,5,6,8,9-hexahydrobenzo[b][1,4,7,10]tetraoxacyclododecine-12-carbonitrile |
| ICOT-021 | 1432922-28-5 | 13-amino-2,3,5,6,8,9-hexahydrobenzo[b][1,4,7,10]tetraoxacyclododecine-12-carbonitrile |
| ICOT-022 | 1432922-34-3 | (E)-N'-(13-cyano-2,3,5,6,8,9-hexahydrobenzo[b][1,4,7,10]tetraoxacyclododecin-12-yl)-N,N-dimethylformimidamide |
| Code | CAS No. | Intermediate |
|---|---|---|
| ICOT-009 | 54060-30-9Available | 3-ethynylaniline |
| ICOT-023 | 1772-76-5 | (E)-3-(3-nitrophenyl)acrylic acid |
| ICOT-024 | - | (2S,3R)-2,3-dibromo-3-(3-nitrophenyl)propanoic acid |
| ICOT-025 | 3034-94-4 | 1-ethynyl-3-nitrobenzene |
Frequently asked questions
What are the approved indications of Icotinib Hydrochloride?
Approved indications include: 非小细胞肺癌.
When does the Icotinib Hydrochloride patent expire?
No public expiry year is available for Icotinib Hydrochloride yet; this page updates once verified.
How many synthesis routes are recorded for Icotinib Hydrochloride?
4 synthesis routes are recorded; the shortest is 3 steps with / total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Icotinib Hydrochloride intermediates?
3 intermediate CAS of Icotinib Hydrochloride are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Icotinib Hydrochloride intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-24