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CAS 1066-54-2
ethynyltrimethylsilane
Codes：RUCA-002、VEMF-016、ICOT-017
Application context (from source-drug indications)
前列腺癌芦卡帕利腹膜癌芦卡帕利卵巢上皮癌芦卡帕利输卵管癌芦卡帕利卵巢癌芦卡帕利去势抵抗性前列腺肿瘤芦卡帕利Erdheim-Chester病维罗非尼黑色素瘤维罗非尼组织细胞增生维罗非尼郎格罕细胞组织细胞增生症维罗非尼非霍奇金淋巴瘤维罗非尼肝胚细胞瘤维罗非尼非小细胞肺癌盐酸埃克替尼肺腺癌盐酸埃克替尼支气管肿瘤盐酸埃克替尼肺癌盐酸埃克替尼转移性乳腺癌盐酸埃克替尼银屑病盐酸埃克替尼
Source drugs (routes using this intermediate)
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
4-bromobenzaldehyde→ethynyltrimethylsilane→4-((trimethylsilyl)ethynyl)benzaldehyde→N-methyl-1-(4-((trimethylsilyl)ethynyl)phenyl)methanamine→methyl methyl(4-((trimethylsilyl)ethynyl)benzyl)carbamate→methyl 4-ethynylbenzyl(methyl)carbamate→methyl 5-fluoro-2-hydroxy-3-nitrobenzoate→methyl 5-fluoro-2-((4-(((methoxycarbonyl)(methyl)amino)methyl)phenyl)ethynyl)-3-nitrobenzoate→methyl 3-amino-5-fluoro-2-((4-(((methoxycarbonyl)(methyl)amino)methyl)phenyl)ethynyl)benzoate→methyl 6-fluoro-2-(4-(((methoxycarbonyl)(methyl)amino)methyl)phenyl)-1H-indole-4-carboxylate→(E)-N,N-dimethyl-2-nitroethenamine→(E)-methyl 6-fluoro-2-(4-(((methoxycarbonyl)(methyl)amino)methyl)phenyl)-3-(2-nitrovinyl)-1H-indole-4-carboxylate→methyl 6-fluoro-2-(4-(((methoxycarbonyl)(methyl)amino)methyl)phenyl)-3-(2-nitroethyl)-1H-indole-4-carboxylate→methyl 4-(8-fluoro-6-oxo-3,4,5,6-tetrahydro-1H-azepino[5,4,3-cd]indol-2-yl)benzyl(methyl)carbamate→5-fluoro-2-hydroxybenzoic acid→methyl 5-fluoro-2-hydroxybenzoate
2,6-difluoro-3-(propylsulfonamido)benzoic acid→(4-chlorophenyl)boronic acid→5-bromopyridin-2-amine→5-(4-chlorophenyl)pyridin-2-amine→5-(4-chlorophenyl)-3-iodopyridin-2-amine→(E)-2-(2-ethoxyvinyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane→5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine→3-bromo-5-(4-chlorophenyl)pyridin-2-amine→ethynyltrimethylsilane→5-(4-chlorophenyl)-3-((trimethylsilyl)ethynyl)pyridin-2-amine
(ethane-1,2-diylbis(oxy))bis(ethane-2,1-diyl) bis(4-methylbenzenesulfonate)→2-amino-4,5-dimethoxybenzoic acid→6,7-dimethoxyquinazolin-4(3H)-one→4-chloro-6,7-dimethoxyquinazoline→3-bromoaniline→N-(3-bromophenyl)-6,7-dimethoxyquinazolin-4-amine→4-((3-bromophenyl)amino)quinazoline-6,7-diol hydrochloride→N-(3-bromophenyl)-7,8,10,11,13,14-hexahydro-[1,4,7,10]tetraoxacyclododecino[2,3-g]quinazolin-4-amine→ethynyltrimethylsilane
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