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Tier C — Watch / trade

Ranolazine

Gilead Sciences Inc

Originator

2006

First approval

Expiry (public)

$0.76B ▲

Peak sales

化学药

Type

Targets：Nav1.5

Brand：Ranexa、Latixa

Indications (approved)：心绞痛

Regional status

临床二期

2007-04-01

批准上市

2008-07-08

China

临床二期

2013-11-01

Japan

Synthetic routes & intermediates3 routes

Originator routes × 1Optimised (non-patent) × 1Process routes × 1

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OriginatorRoute 2Steps 3 · Total yield 140 g

Code	CAS No.	Intermediate
RANO-003	1131-01-7	2-chloro-N-(2,6-dimethylphenyl)acetamide
RANO-004	110-85-0 Available	piperazine
RANO-006	2210-74-4	2-((2-methoxyphenoxy)methyl)oxirane
RANO-007	90-05-1	2-methoxyphenol
RANO-008	106-89-8	2-(chloromethyl)oxirane
RANO-009	162712-35-8	1-(2-methoxyphenoxy)-3-(piperazin-1-yl)propan-2-ol

OptimisedRoute 3Steps 6 · Total yield 4.35 g

Synthetic routes & intermediates Route 3

Code	CAS No.	Intermediate
RANO-001	79-04-9 Available	2-chloroacetyl chloride
RANO-002	87-62-7	2,6-dimethylaniline
RANO-003	1131-01-7	2-chloro-N-(2,6-dimethylphenyl)acetamide
RANO-006	2210-74-4	2-((2-methoxyphenoxy)methyl)oxirane
RANO-007	90-05-1	2-methoxyphenol
RANO-008	106-89-8	2-(chloromethyl)oxirane
RANO-010	111-42-2	2,2'-azanediylbis(ethan-1-ol)
RANO-011	20846-30-4	2-(bis(2-hydroxyethyl)amino)-N-(2,6-dimethylphenyl)acetamide
RANO-012	756788-45-1	2-(bis(2-chloroethyl)amino)-N-(2,6-dimethylphenyl)acetamide
RANO-013	63257-76-1	1-amino-3-(2-methoxyphenoxy)propan-2-ol

ProcessRoute 1Steps 3 · Total yield 5.9 kg

Synthetic routes & intermediates Route 1

Code	CAS No.	Intermediate
RANO-001	79-04-9 Available	2-chloroacetyl chloride
RANO-002	87-62-7	2,6-dimethylaniline
RANO-003	1131-01-7	2-chloro-N-(2,6-dimethylphenyl)acetamide
RANO-004	110-85-0 Available	piperazine
RANO-005	5294-61-1	N-(2,6-dimethylphenyl)-2-(piperazin-1-yl)acetamide
RANO-006	2210-74-4	2-((2-methoxyphenoxy)methyl)oxirane

Frequently asked questions

What are the approved indications of Ranolazine?

Approved indications include: 心绞痛.

When does the Ranolazine patent expire?

No public expiry year is available for Ranolazine yet; this page updates once verified.

How many synthesis routes are recorded for Ranolazine?

3 synthesis routes are recorded; the shortest is 3 steps with 5.9 kg total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Ranolazine intermediates?

2 intermediate CAS of Ranolazine are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.

How do I get a quote for Ranolazine intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-24