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Pemetrexed Disodium Hydrate
Tier C — Watch / tradePemetrexed Disodium Hydrate
Eli Lilly and Company
Originator
2004
First approval
-
Expiry (public)
No sales data
Peak sales
Small molecule
Type
Targets：DHFR, GART, TYMS
Brand：Rolazar, Alimta, Tifolar, PEMRYDI RTU
Indications (approved)：Non-small cell lung cancer, 间皮组织肿瘤, 胸膜孤立性纤维瘤
Regional status
US
Approved
2004-02-04
EU
Approved
2004-09-20
China
Approved
2005-01-01
Japan
Approved
2007-01-04
Synthetic routes & intermediates5 routes
Originator routes × 1Optimised (non-patent) × 3Process routes × 1
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
OriginatorRoute 1Steps 6 · Total yield 0.8 g
PEME-0017355-55-7PEME-0023282-30-2PEME-003137281-08-4PEME-004137281-09-5PEME-005137281-11-9PEME-006135352-72-6PEME-007137281-12-0PEME-008155405-81-5API · Pemetrexed Disodium Hydrate
| Code | CAS No. | Intermediate |
|---|---|---|
| PEME-001 | 7355-55-7 | 2-amino-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one |
| PEME-002 | 3282-30-2 | pivaloyl chloride |
| PEME-003 | 137281-08-4 | N-(4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-2-yl)pivalamide |
| PEME-004 | 137281-09-5 | N-(5,6-diiodo-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-2-yl)pivalamide |
| PEME-005 | 137281-11-9 | N-(5-iodo-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-2-yl)pivalamide |
| PEME-006 | 135352-72-6 | dimethyl (4-ethynylbenzoyl)-L-glutamate |
| PEME-007 | 137281-12-0 | dimethyl (4-((4-oxo-2-pivalamido-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethynyl)benzoyl)-L-glutamate |
| PEME-008 | 155405-81-5 | dimethyl (4-(2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzoyl)-L-glutamate |
OptimisedRoute 3Steps 6 · Total yield 201 mg
PEME-008155405-81-5PEME-017137281-39-1PEME-019151864-81-2PEME-02032446-47-2PEME-021151864-82-3PEME-022109-77-3PEME-023151864-76-5PEME-024113-00-8PEME-025151864-73-2PEME-02616450-41-2API · Pemetrexed Disodium Hydrate
| Code | CAS No. | Intermediate |
|---|---|---|
| PEME-008 | 155405-81-5 | dimethyl (4-(2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzoyl)-L-glutamate |
| PEME-017 | 137281-39-1 | 4-(2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzoic acid |
| PEME-019 | 151864-81-2 | ethyl 4-(3-oxopropyl)benzoate |
| PEME-020 | 32446-47-2 | 3-ethylbenzo[d]thiazol-3-ium bromide |
| PEME-021 | 151864-82-3 | ethyl 4-(4-hydroxy-3-oxobutyl)benzoate |
| PEME-022 | 109-77-3 | malononitrile |
| PEME-023 | 151864-76-5 | ethyl 4-(2-(5-amino-4-cyanofuran-3-yl)ethyl)benzoate |
| PEME-024 | 113-00-8 | guanidine |
| PEME-025 | 151864-73-2 | ethyl 4-(2-(2,4-diamino-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzoate |
| PEME-026 | 16450-41-2 | (S)-diethyl 2-aminopentanedioate |
OptimisedRoute 4Steps 9 · Total yield /
PEME-024113-00-8PEME-02798-84-0PEME-02879-22-1PEME-02976926-67-5PEME-0304784-77-4PEME-031—PEME-032348620-13-3PEME-033108-59-8PEME-034348620-14-4PEME-035243636-52-4PEME-036243636-55-7PEME-037243636-56-8PEME-038116387-21-4PEME-039243636-57-9API · Pemetrexed Disodium Hydrate
| Code | CAS No. | Intermediate |
|---|---|---|
| PEME-024 | 113-00-8 | guanidine |
| PEME-027 | 98-84-0Available | 1-phenylethan-1-amine |
| PEME-028 | 79-22-1 | methyl carbonochloridate |
| PEME-029 | 76926-67-5 | methyl (1-phenylethyl)carbamate |
| PEME-030 | 4784-77-4 | (E)-1-bromobut-2-ene |
| PEME-031 | - | methyl (E)-but-2-en-1-yl(1-phenylethyl)carbamate |
| PEME-032 | 348620-13-3 | (E)-N-(1-phenylethyl)but-2-en-1-amine |
| PEME-033 | 108-59-8Available | dimethyl malonate |
| PEME-034 | 348620-14-4 | methyl (E)-3-(but-2-en-1-yl(1-phenylethyl)amino)-3-oxopropanoate |
| PEME-035 | 243636-52-4 | methyl 2-oxo-1-(1-phenylethyl)-4-vinylpyrrolidine-3-carboxylate |
| PEME-036 | 243636-55-7 | methyl 1-(1-phenylethyl)-2-thioxo-4-vinylpyrrolidine-3-carboxylate |
| PEME-037 | 243636-56-8 | 2-amino-7-(1-phenylethyl)-5-vinyl-3,5,6,7-tetrahydro-4H-pyrrolo[2,3-d]pyrimidin-4-one |
| PEME-038 | 116387-21-4 | diethyl (4-iodobenzoyl)-L-glutamate |
| PEME-039 | 243636-57-9 | diethyl (4-(2-(2-amino-4-oxo-7-(1-phenylethyl)-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzoyl)-L-glutamate |
OptimisedRoute 5Steps 5 · Total yield 50 mg
PEME-008155405-81-5PEME-01556-06-4PEME-017137281-39-1PEME-019151864-81-2PEME-02032446-47-2PEME-021151864-82-3API · Pemetrexed Disodium Hydrate
| Code | CAS No. | Intermediate |
|---|---|---|
| PEME-008 | 155405-81-5 | dimethyl (4-(2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzoyl)-L-glutamate |
| PEME-015 | 56-06-4 | 2,6-diaminopyrimidin-4(3H)-one |
| PEME-017 | 137281-39-1 | 4-(2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzoic acid |
| PEME-019 | 151864-81-2 | ethyl 4-(3-oxopropyl)benzoate |
| PEME-020 | 32446-47-2 | 3-ethylbenzo[d]thiazol-3-ium bromide |
| PEME-021 | 151864-82-3 | ethyl 4-(4-hydroxy-3-oxobutyl)benzoate |
ProcessRoute 2Steps 8 · Total yield 3.6 kg
PEME-009619-42-1PEME-010927-74-2PEME-011123910-86-1PEME-012123910-88-3PEME-013106200-41-3PEME-014155405-79-1PEME-01556-06-4PEME-016155405-80-4PEME-017137281-39-1PEME-018—API · Pemetrexed Disodium Hydrate
| Code | CAS No. | Intermediate |
|---|---|---|
| PEME-009 | 619-42-1 | methyl 4-bromobenzoate |
| PEME-010 | 927-74-2 | but-3-yn-1-ol |
| PEME-011 | 123910-86-1 | methyl 4-(4-hydroxybut-1-yn-1-yl)benzoate |
| PEME-012 | 123910-88-3 | methyl 4-(4-hydroxybutyl)benzoate |
| PEME-013 | 106200-41-3 | methyl 4-(4-oxobutyl)benzoate |
| PEME-014 | 155405-79-1 | methyl 4-(3-bromo-4-oxobutyl)benzoate |
| PEME-015 | 56-06-4 | 2,6-diaminopyrimidin-4(3H)-one |
| PEME-016 | 155405-80-4 | methyl 4-(2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzoate |
| PEME-017 | 137281-39-1 | 4-(2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzoic acid |
| PEME-018 | - | diethyl (4-(2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzoyl)-L-glutamate compound with 4-methylbenzenesulfonamide (1:1) |
Frequently asked questions
What are the approved indications of Pemetrexed Disodium Hydrate?
Approved indications include: Non-small cell lung cancer, 间皮组织肿瘤, 胸膜孤立性纤维瘤.
When does the Pemetrexed Disodium Hydrate patent expire?
No public expiry year is available for Pemetrexed Disodium Hydrate yet; this page updates once verified.
How many synthesis routes are recorded for Pemetrexed Disodium Hydrate?
5 synthesis routes are recorded; the shortest is 5 steps with 50 mg total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Pemetrexed Disodium Hydrate intermediates?
2 intermediate CAS of Pemetrexed Disodium Hydrate are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Pemetrexed Disodium Hydrate intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-27