吡仑帕奈

Tier C — Watch / trade

Perampanel Hydrate · all drugs expiring in 2028 →

卫材株式会社

Originator

2012

First approval

2028

Expiry (public)

$0.28B ▲

Peak sales

化学药

Type

Targets：AMPAR

Brand：Fycompa

Indications (approved)：强直阵挛性癫痫、癫痫部分性发作、癫痫、癫痫发作

Regional status

批准上市

2012-10-22

批准上市

2012-07-23

China

批准上市

2019-09-29

Japan

批准上市

2016-03-28

Synthetic routes & intermediates5 routes

Originator routes × 1Optimised (non-patent) × 4Process routes × 0

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OriginatorRoute 1Steps 6 · Total yield /

Code	CAS No.	Intermediate
PERAM-001	1072-97-5	5-bromopyridin-2-amine
PERAM-002	381233-96-1	5-bromo-3-iodopyridin-2-amine
PERAM-003	381233-75-6	5-bromo-3-iodopyridin-2(1H)-one
PERAM-004	98-80-6	phenylboronic acid
PERAM-005	381233-76-7	5-bromo-3-iodo-1-phenylpyridin-2(1H)-one
PERAM-006	172732-52-4	2-(1,3,2-dioxaborinan-2-yl)benzonitrile
PERAM-007	381233-77-8	2-(5-bromo-2-oxo-1-phenyl-1,2-dihydropyridin-3-yl)benzonitrile
PERAM-008	381250-74-4	2-(2-oxo-1-phenyl-5-(tributylstannyl)-1,2-dihydropyridin-3-yl)benzonitrile
PERAM-009	109-09-1	2-chloropyridine

OptimisedRoute 2Steps 8 · Total yield 0.06 g

Synthetic routes & intermediates Route 2

Code	CAS No.	Intermediate
PERAM-004	98-80-6	phenylboronic acid
PERAM-006	172732-52-4	2-(1,3,2-dioxaborinan-2-yl)benzonitrile
PERAM-010	624-28-2	2,5-dibromopyridine
PERAM-011	13472-85-0	5-bromo-2-methoxypyridine
PERAM-012	17997-47-6	2-(tributylstannyl)pyridine
PERAM-013	381725-49-1	6'-methoxy-2,3'-bipyridine
PERAM-014	381233-78-9	[2,3'-bipyridin]-6'(1'H)-one
PERAM-015	381233-79-0	5'-bromo-[2,3'-bipyridin]-6'(1'H)-one
PERAM-016	381248-05-1	5'-bromo-6'-methoxy-2,3'-bipyridine
PERAM-017	380917-95-3	2-(6'-methoxy-[2,3'-bipyridin]-5'-yl)benzonitrile
PERAM-018	380917-96-4	2-(6'-oxo-1',6'-dihydro-[2,3'-bipyridin]-5'-yl)benzonitrile

OptimisedRoute 3Steps 7 · Total yield 168.3 g

Synthetic routes & intermediates Route 3

Code	CAS No.	Intermediate
PERAM-006	172732-52-4	2-(1,3,2-dioxaborinan-2-yl)benzonitrile
PERAM-011	13472-85-0	5-bromo-2-methoxypyridine
PERAM-013	381725-49-1	6'-methoxy-2,3'-bipyridine
PERAM-014	381233-78-9	[2,3'-bipyridin]-6'(1'H)-one
PERAM-019	1628-89-3	2-methoxypyridine
PERAM-020	24244-60-8	2-(phenylsulfonyl)pyridine
PERAM-021	381725-50-4	1'-phenyl-[2,3'-bipyridin]-6'(1'H)-one
PERAM-022	381248-06-2	5'-bromo-1'-phenyl-[2,3'-bipyridin]-6'(1'H)-one

OptimisedRoute 4Steps 5 · Total yield 62.8 g

Synthetic routes & intermediates Route 4

Code	CAS No.	Intermediate
PERAM-025	914918-74-4	5-acetyl-1-phenylpyridin-2(1H)-one
PERAM-026	1622863-49-3	5-acetyl-3-bromo-1-phenylpyridin-2(1H)-one
PERAM-027	214360-79-9	2-(1,3,2-dioxaborolan-2-yl)benzonitrile
PERAM-028	1622863-50-6	2-(5-acetyl-2-oxo-1-phenyl-1,2-dihydropyridin-3-yl)benzonitrile
PERAM-029	927-63-9	(E)-3-(dimethylamino)acrylaldehyde
PERAM-004	98-80-6	phenylboronic acid
PERAM-023	55676-22-7	1-(6-chloropyridin-3-yl)ethanone
PERAM-024	1124-29-4	5-acetylpyridin-2(1H)-one

OptimisedRoute 5Steps 3 · Total yield 17.7 g

Synthetic routes & intermediates Route 5

Code	CAS No.	Intermediate
PERAM-030	18698-99-2	2-(2-cyanophenyl)acetic acid
PERAM-031	62-53-3	aniline
PERAM-032	71732-86-0	2-(2-cyanophenyl)-N-phenylacetamide
PERAM-033	1646529-95-4	-
PERAM-034	16179-97-8	2-(pyridin-2-yl)acetic acid hydrochloride

Frequently asked questions

What are the approved indications of Perampanel Hydrate?

Approved indications include: 强直阵挛性癫痫, 癫痫部分性发作, 癫痫, 癫痫发作.

When does the Perampanel Hydrate patent expire?

Based on public sources, the Perampanel Hydrate patent expires in 2028.

How many synthesis routes are recorded for Perampanel Hydrate?

5 synthesis routes are recorded; the shortest is 3 steps with 17.7 g total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Perampanel Hydrate intermediates?

All intermediates in Perampanel Hydrate routes have CAS profiles — you can submit an RFQ per CAS and it enters the Unibest matching pool.

How do I get a quote for Perampanel Hydrate intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-24