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CAS 1056149-69-9
(E)-4-(dimethylamino)but-2-enoyl chloride
Codes：NERT-003、AFAT-025
Application context (from source-drug indications)
乳腺癌马来酸奈拉替尼非小细胞肺癌马来酸阿法替尼头颈部鳞状细胞癌马来酸阿法替尼头颈癌马来酸阿法替尼脊索瘤马来酸阿法替尼鳞状细胞癌马来酸阿法替尼胆囊癌马来酸阿法替尼
Source drugs (routes using this intermediate)
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
3-chloro-4-fluoroaniline→(S)-tetrahydrofuran-3-ol→methyl 3-amino-4-hydroxybenzoate→methyl 5-amino-4-hydroxy-2-nitrobenzoate→methyl 2,5-diamino-4-hydroxybenzoate→6-amino-7-hydroxyquinazolin-4(3H)-one→6-amino-4-chloroquinazolin-7-ol→(S)-4-chloro-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-amine→(E)-4-(dimethylamino)but-2-enoyl chloride→(S,E)-N-(4-chloro-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide
3-chloro-4-fluoroaniline→(S)-tetrahydrofuran-3-ol→(E)-4-(dimethylamino)but-2-enoyl chloride→4-hydroxybenzonitrile→4-hydroxy-3-nitrobenzonitrile→(S)-3-nitro-4-((tetrahydrofuran-3-yl)oxy)benzonitrile→(S)-3-amino-4-((tetrahydrofuran-3-yl)oxy)benzonitrile→(S,E)-N-(5-cyano-2-((tetrahydrofuran-3-yl)oxy)phenyl)-4-(dimethylamino)but-2-enamide→(S,E)-N-(5-cyano-4-nitro-2-((tetrahydrofuran-3-yl)oxy)phenyl)-4-(dimethylamino)but-2-enamide→(S,E)-N-(4-amino-5-cyano-2-((tetrahydrofuran-3-yl)oxy)phenyl)-4-(dimethylamino)but-2-enamide→(E)-N-(5-cyano-4-((E)-((dimethylamino)methylene)amino)-2-(((S)-tetrahydrofuran-3-yl)oxy)phenyl)-4-(dimethylamino)but-2-enamide
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