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CAS 106941-25-7
((2-(6-amino-9H-purin-9-yl)ethoxy)methyl)phosphonic acid
Codes: ADEF-001
Application context (from source-drug indications)
Hepatitis BAdefovir DipivoxilChronic hepatitis BAdefovir DipivoxilHIV infectionAdefovir DipivoxilLiver transplant rejectionAdefovir DipivoxilHepatitisAdefovir Dipivoxil巨细胞病毒感染Adefovir Dipivoxil
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Adefovir Dipivoxil | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
((2-(6-amino-9H-purin-9-yl)ethoxy)methyl)phosphonic acid→chloromethyl pivalate
((2-(6-amino-9H-purin-9-yl)ethoxy)methyl)phosphonic acid→chloromethyl pivalate→9H-purin-6-amine→1,3-dioxolan-2-one→2-(6-amino-9H-purin-9-yl)ethan-1-ol→(diethoxyphosphoryl)methyl 4-methylbenzenesulfonate→diethyl ((2-(6-amino-9H-purin-9-yl)ethoxy)methyl)phosphonate
((2-(6-amino-9H-purin-9-yl)ethoxy)methyl)phosphonic acid→chloromethyl pivalate→9H-purin-6-amine→diethyl ((2-chloroethoxy)methyl)phosphonate
Intermediates available on this site
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