CAS 18997-19-8

chloromethyl pivalate

Codes: ADEF-002

Application context (from source-drug indications)

Hepatitis BAdefovir DipivoxilChronic hepatitis BAdefovir DipivoxilHIV infectionAdefovir DipivoxilLiver transplant rejectionAdefovir DipivoxilHepatitisAdefovir Dipivoxil巨细胞病毒感染Adefovir Dipivoxil

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Adefovir Dipivoxil	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Adefovir DipivoxilOriginator routesteps: 1total yield: 0.59 g

((2-(6-amino-9H-purin-9-yl)ethoxy)methyl)phosphonic acid→chloromethyl pivalate

Adefovir DipivoxilOptimised routesteps: 4total yield: /

((2-(6-amino-9H-purin-9-yl)ethoxy)methyl)phosphonic acid→chloromethyl pivalate→9H-purin-6-amine→1,3-dioxolan-2-one→2-(6-amino-9H-purin-9-yl)ethan-1-ol→(diethoxyphosphoryl)methyl 4-methylbenzenesulfonate→diethyl ((2-(6-amino-9H-purin-9-yl)ethoxy)methyl)phosphonate

Adefovir DipivoxilOptimised routesteps: 2total yield: /

((2-(6-amino-9H-purin-9-yl)ethoxy)methyl)phosphonic acid→chloromethyl pivalate→9H-purin-6-amine→diethyl ((2-chloroethoxy)methyl)phosphonate

Intermediates available on this site

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