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CAS 1187-27-5

Methyl 2-cyano-3-(dimethylamino)prop-2-enoate

Codes:Cefoselis Sulfate-015

Application context (from source-drug indications)

细菌感染硫酸头孢噻利

Source drugs (routes using this intermediate)

DrugTierExpiry
硫酸头孢噻利Cefoselis SulfateTier C — Watch / trade-

Position in synthesis routes (up/downstream chain)

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硫酸头孢噻利优化路线steps: 10total yield: 231. 2g(Cefoselis Sulfate-001)
2-(5-Amino-1H-pyrazol-1-yl)ethan-1-ol→N,N-Dimethylformamide→2-Cyanoacetic acid methyl ester→2-Cyanoacetic acid ethyl ester→Propyl cyanoacetate→Butyl cyanoacetate→Methyl 2-cyano-3-(dimethylamino)prop-2-enoate→Ethyl 2-cyano-3-(dimethylamino)prop-2-enoate→Propyl 2-cyano-3-(dimethylamino)prop-2-enoate→Butyl 2-cyano-3-(dimethylamino)prop-2-enoate→2-Hydrazinoethanol→Methyl 5-amino-1-(2-hydroxyethyl)-1H-pyrazole-4-carboxylate→Ethyl 5-amino-1-(2-hydroxyethyl)-1H-pyrazole-4-carboxylate→Propyl 5-amino-1-(2-hydroxyethyl)-1H-pyrazole-4-carboxylate→Butyl 5-amino-1-(2-hydroxyethyl)-1H-pyrazole-4-carboxylate→5-Amino-1-(2-hydroxyethyl)-1H-pyrazole-4-carboxylic acid→Hex-3-enedinitrile→But-3-enenitrile→3-Oxopropanenitrile→3,3-Dimethoxypropanenitrile→3-[2-(2-Hydroxyethyl)hydrazinylidene]propanenitrile

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