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CAS 1334429-35-4

1,3-Benzoxazol-6-yl(morpholin-4-yl)methanonebenzo[d]oxazol-6-yl(morpholino)methanone

Codes(V)409139-2-a、TAFA-007

Application context (from source-drug indications)

转甲状腺素运载蛋白淀粉样变性氯苯唑酸心脏病氯苯唑酸淀粉样多神经病氯苯唑酸葡甲胺转甲状腺素运载蛋白淀粉样变性氯苯唑酸葡甲胺淀粉样变氯苯唑酸葡甲胺心肌疾病氯苯唑酸葡甲胺淀粉体轻链淀粉样变性氯苯唑酸葡甲胺家族性淀粉样神经病氯苯唑酸葡甲胺

Source drugs (routes using this intermediate)

DrugTierExpiry
氯苯唑酸TafamidisTier C — Watch / trade-
氯苯唑酸葡甲胺Tafamidis MeglumineTier B — Position early-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

氯苯唑酸优化路线steps: 5total yield: /
(4-Carboxy-2-hydroxyphenyl)amineOrthoformic acid trimethyl ester1,3-Benzoxazole-6-carboxylic acid1,3-Benzoxazole-6-carbonyl chloride1,3-Benzoxazol-6-yl(morpholin-4-yl)methanone1,3-Dichloro-5-iodobenzene[2-(3,5-Dichlorophenyl)-1,3-benzoxazol-6-yl]-morpholinomethanone2-(3,5-Dichlorophenyl)benzo[d]oxazole-6-carboxylic acid
氯苯唑酸葡甲胺优化路线steps: 4total yield: 24.7 mg
4-amino-3-hydroxybenzoic acidbenzo[d]oxazole-6-carboxylic acidbenzo[d]oxazol-6-yl(morpholino)methanone1,3-dichloro-5-iodobenzene(2-(3,5-dichlorophenyl)benzo[d]oxazol-6-yl)(morpholino)methanone

Intermediates available on this site

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