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CAS 594839-88-0

2-(3,5-Dichlorophenyl)benzo[d]oxazole-6-carboxylic acid2-(3,5-dichlorophenyl)benzo[d]oxazole-6-carboxylic acid

Codes:(VIII)409139-2-a、(X)409139-3-a、(VI)409139-4-a、(VI)409139-5-a、(IX)409139-6-a、(IV)409139-7-a、(IV)409139-9-a、(VII)409139-12-a、TAFA-004、(VIII)409139-1-a、(VI)409139-10-a

Application context (from source-drug indications)

转甲状腺素运载蛋白淀粉样变性氯苯唑酸心脏病氯苯唑酸淀粉样多神经病氯苯唑酸葡甲胺转甲状腺素运载蛋白淀粉样变性氯苯唑酸葡甲胺淀粉样变氯苯唑酸葡甲胺心肌疾病氯苯唑酸葡甲胺淀粉体轻链淀粉样变性氯苯唑酸葡甲胺家族性淀粉样神经病氯苯唑酸葡甲胺

Source drugs (routes using this intermediate)

DrugTierExpiry
氯苯唑酸TafamidisTier C — Watch / trade-
氯苯唑酸葡甲胺Tafamidis MeglumineTier B — Position early-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

氯苯唑酸优化路线steps: 5total yield: /
(4-Carboxy-2-hydroxyphenyl)amine→Orthoformic acid trimethyl ester→1,3-Benzoxazole-6-carboxylic acid→1,3-Benzoxazole-6-carbonyl chloride→1,3-Benzoxazol-6-yl(morpholin-4-yl)methanone→1,3-Dichloro-5-iodobenzene→[2-(3,5-Dichlorophenyl)-1,3-benzoxazol-6-yl]-morpholinomethanone→2-(3,5-Dichlorophenyl)benzo[d]oxazole-6-carboxylic acid
氯苯唑酸优化路线steps: 2total yield: /
1-Ethyl-3-hydroxybenzene→(3,5-Dichlorophenyl)methanamine→2-(3,5-Dichlorophenyl)-6-ethyl-1,3-benzoxazole→2-(3,5-Dichlorophenyl)benzo[d]oxazole-6-carboxylic acid→4-Oxocyclohexanecarboxylic acid ethyl ester→Ethyl 2-(3,5-dichlorophenyl)-1,3-benzoxazole-6-carboxylate
氯苯唑酸优化路线steps: 4total yield: /
3,5-Dichloroaniline→2,3-Butanedione→1-(3,5-Dichlorophenyl)ethanone→(3,5-Dichlorophenyl)(oxo)acetic acid→2-Amino-5-methylphenol→2-(3,5-Dichlorophenyl)-6-methyl-1,3-benzoxazole→2-(3,5-Dichlorophenyl)benzo[d]oxazole-6-carboxylic acid

Intermediates available on this site

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