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CAS 2374-03-0
(4-Carboxy-2-hydroxyphenyl)amine4-amino-3-hydroxybenzoic acid
Codes：(I)409139-2-a、(IX)409139-3-a、(V)409139-4-a、(V)409139-5-a、(VIII)409139-6-a、(IId)409139-7-a、TAFA-001、(IIIa)409139-1-a、(I)409139-10-a
Application context (from source-drug indications)
转甲状腺素运载蛋白淀粉样变性氯苯唑酸心脏病氯苯唑酸淀粉样多神经病氯苯唑酸葡甲胺转甲状腺素运载蛋白淀粉样变性氯苯唑酸葡甲胺淀粉样变氯苯唑酸葡甲胺心肌疾病氯苯唑酸葡甲胺淀粉体轻链淀粉样变性氯苯唑酸葡甲胺家族性淀粉样神经病氯苯唑酸葡甲胺
Source drugs (routes using this intermediate)
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
(4-Carboxy-2-hydroxyphenyl)amine→Orthoformic acid trimethyl ester→1,3-Benzoxazole-6-carboxylic acid→1,3-Benzoxazole-6-carbonyl chloride→1,3-Benzoxazol-6-yl(morpholin-4-yl)methanone→1,3-Dichloro-5-iodobenzene→[2-(3,5-Dichlorophenyl)-1,3-benzoxazol-6-yl]-morpholinomethanone→2-(3,5-Dichlorophenyl)benzo[d]oxazole-6-carboxylic acid
3,5-Dichloro-1-benzenecarbonyl chloride→3,5-Dichloro-N-methyl-N-phenylbenzamide→N-[(3,5-Dichlorophenyl)(methoxy)methylidene]-N-methylbenzeniminium trifluoromethanesulfonate→1,3-Dichloro-5-(trimethoxymethyl)benzene→2-(Hydroxymethyl)-2-phenylpropane-1,3-diol→2-Phenylacetaldehyde→2-Ethyl-2-(hydroxymethyl)propane-1,3-diol→1-(3,5-Dichlorophenyl)-4-phenyl-2,6,7-trioxabicyclo[2.2.2]octane→1-(3,5-Dichlorophenyl)-4-ethyl-2,6,7-trioxabicyclo[2.2.2]octane→(4-Carboxy-2-hydroxyphenyl)amine→2-(3,5-Dichlorophenyl)benzo[d]oxazole-6-carboxylic acid
3-Methylbutanal→3,3-Dimethylbutanal→2-(Hydroxymethyl)-2-(propan-2-yl)propane-1,3-diol→2-tert-Butyl-2-(hydroxymethyl)propane-1,3-diol→3,5-Dichlorobenzoic acid→1-(3,5-Dichlorophenyl)-4-(propan-2-yl)-2,6,7-trioxabicyclo[2.2.2]octane→4-tert-Butyl-1-(3,5-dichlorophenyl)-2,6,7-trioxabicyclo[2.2.2]octane→(4-Carboxy-2-hydroxyphenyl)amine→2-(3,5-Dichlorophenyl)benzo[d]oxazole-6-carboxylic acid
1,3-Dichloro-5-(trimethoxymethyl)benzene→(±)-1,2,4-Butanetriol→1-(3,5-Dichlorophenyl)-2,7,8-trioxabicyclo[3.2.1]octane→1,2-Dihydroxyethane→2-(3,5-Dichlorophenyl)-2-methoxy-1,3-dioxolane→cis-Cyclohexane-1,3,5-triol→3-(3,5-Dichlorophenyl)-2,4,10-trioxaadamantane→(4-Carboxy-2-hydroxyphenyl)amine→2-(3,5-Dichlorophenyl)benzo[d]oxazole-6-carboxylic acid
3,5-Dichlorobenzaldehyde→3,5-Dichlorobenzoic acid→2-Amino-5-methylphenol→1-Amino-2-hydroxy-4-ethylbenzene→2-Amino-5-butylphenol→(4-Carboxy-2-hydroxyphenyl)amine→2-(3,5-Dichlorophenyl)-6-methyl-1,3-benzoxazole→2-(3,5-Dichlorophenyl)-6-ethyl-1,3-benzoxazole→6-Butyl-2-(3,5-dichlorophenyl)-1,3-benzoxazole→2-(3,5-Dichlorophenyl)benzo[d]oxazole-6-carboxylic acid→4-([(1E)-(3,5-Dichlorophenyl)methylene]amino)-3-hydroxybenzoic acid
4-amino-3-hydroxybenzoic acid→benzo[d]oxazole-6-carboxylic acid→benzo[d]oxazol-6-yl(morpholino)methanone→1,3-dichloro-5-iodobenzene→(2-(3,5-dichlorophenyl)benzo[d]oxazol-6-yl)(morpholino)methanone
3,5-Dichlorobenzoic acid→3,5-Dichloro-1-benzenecarbonyl chloride→(4-Carboxy-2-hydroxyphenyl)amine→2-Bromo-4-methoxycarbonylaniline→2-Hydroxy-4-methoxycarbonylaniline→4-Amino-3-hydroxybenzoic acid methyl ester hydrochloride→4-(3,5-Dichlorobenzamido)-3-hydroxybenzoic acid→Methyl 3-bromo-4-(3,5-dichlorobenzamido)benzoate→Methyl 4-(3,5-dichlorobenzamido)-3-hydroxybenzoate→2-(3,5-Dichlorophenyl)benzoxazole-6-carboxylic acid methyl ester→Methyl 1,3-benzoxazole-6-carboxylate→1,3-Bis(chloranyl)benzene→2-(3,5-Dichlorophenyl)benzo[d]oxazole-6-carboxylic acid→3-Carboxyphenol→3-Carboxy-6-nitrophenol
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