CAS 142470-47-1

5-(Difluoromethoxy)-2-{[(3,4-dimethoxypyridin-2-yl)methyl]sulfanyl}-1H-benzimidazole

Codes：S-pantoprazole sodium-005

Application context (from source-drug indications)

胃食管反流病（S）-泮托拉唑钠消化性溃疡（S）-泮托拉唑钠出血（S）-泮托拉唑钠创伤和损伤（S）-泮托拉唑钠昏迷（S）-泮托拉唑钠吸入性肺炎（S）-泮托拉唑钠

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
（S）-泮托拉唑钠S-pantoprazole sodium	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

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（S）-泮托拉唑钠优化路线steps: 3total yield: 4g((S)-(-)-Pantoprazole sodium (API))

potassium (ethoxymethanethioyl)sulfanide→1,2-Diamino-4-(difluoromethoxy)benzene→5-(Difluoromethoxy)-1H-benzimidazole-2-thiol→2-(chloromethyl)-3,4-dimethoxypyridine→5-(Difluoromethoxy)-2-{[(3,4-dimethoxypyridin-2-yl)methyl]sulfanyl}-1H-benzimidazole

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