CAS 145783-15-9

4,6-dichloro-2-(propylthio)pyrimidin-5-amine

Codes：TICA-027

Application context (from source-drug indications)

中风替格瑞洛急性冠脉综合征替格瑞洛心肌梗塞替格瑞洛外周血管疾病替格瑞洛

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
替格瑞洛Ticagrelor	Tier B — Position early	2029

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

替格瑞洛优化路线steps: 9total yield: 19 mg

(1R,2S)-2-(3,4-difluorophenyl)cyclopropan-1-amine→2-(((3aR,4S,6R,6aS)-6-(7-(((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyltetrahydro-4H-cyclopenta[d][1,3]dioxol-4-yl)oxy)ethan-1-ol→6-hydroxy-2-thioxo-2,3-dihydropyrimidin-4(1H)-one→1-iodopropane→2-(propylthio)pyrimidine-4,6-diol→p-toluidine→(E)-2-(propylthio)-5-(p-tolyldiazenyl)pyrimidine-4,6-diol→(E)-4,6-dichloro-2-(propylthio)-5-(p-tolyldiazenyl)pyrimidine→4,6-dichloro-2-(propylthio)-5-(2-(p-tolyl)hydrazinyl)pyrimidine→4,6-dichloro-2-(propylthio)pyrimidin-5-amine→2-(((3aR,4S,6R,6aS)-6-amino-2,2-dimethyltetrahydro-4H-cyclopenta[d][1,3]dioxol-4-yl)oxy)ethan-1-ol→2-(((3aR,4S,6R,6aS)-6-((5-amino-6-chloro-2-(propylthio)pyrimidin-4-yl)amino)-2,2-dimethyltetrahydro-4H-cyclopenta[d][1,3]dioxol-4-yl)oxy)ethan-1-ol→2-(((3aR,4S,6R,6aS)-6-(7-chloro-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyltetrahydro-4H-cyclopenta[d][1,3]dioxol-4-yl)oxy)ethan-1-ol

替格瑞洛优化路线steps: 5total yield: 192 mg

4,6-dichloro-2-(propylthio)pyrimidin-5-amine→diethyl 2-acetamidomalonate→thiourea→sodium 5-acetamido-4,6-dihydroxypyrimidine-2-thiolate→N-(4,6-dihydroxy-2-mercaptopyrimidin-5-yl)acetamide→1-bromopropane→N-(4,6-dihydroxy-2-(propylthio)pyrimidin-5-yl)acetamide→5-amino-2-(propylthio)pyrimidine-4,6-diol hydrochloride

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Qualified Partner — East China API Works	4,6-Dichloro-2-(propylthio)pyrimidin -5-amine Pharmaceutical Intermediates	询价	询价	询价	—

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