CAS 1549834-56-1

N-(4,6-dihydroxy-2-(propylthio)pyrimidin-5-yl)acetamide

Codes：TICA-045

Application context (from source-drug indications)

中风替格瑞洛急性冠脉综合征替格瑞洛心肌梗塞替格瑞洛外周血管疾病替格瑞洛

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
替格瑞洛Ticagrelor	Tier B — Position early	2029

Position in synthesis routes (up/downstream chain)

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替格瑞洛优化路线steps: 5total yield: 192 mg

4,6-dichloro-2-(propylthio)pyrimidin-5-amine→diethyl 2-acetamidomalonate→thiourea→sodium 5-acetamido-4,6-dihydroxypyrimidine-2-thiolate→N-(4,6-dihydroxy-2-mercaptopyrimidin-5-yl)acetamide→1-bromopropane→N-(4,6-dihydroxy-2-(propylthio)pyrimidin-5-yl)acetamide→5-amino-2-(propylthio)pyrimidine-4,6-diol hydrochloride

Intermediates available on this site

Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.

Supplier	Product	Price band	MOQ	Lead time	Qualifications
Qualified Partner — East China API Works	4,6-Dichloro-2-(propylthio)pyrimidin -5-amine Pharmaceutical Intermediates	询价	询价	询价	—
Unibest Nantong cGMP Site	2-((3aR,4S,6R,6aS)-6-amino-2,2-dimethyltetrahydro -3aH-cyclopenta[d][1,3]dioxol -4-yloxy)ethanol L-tataric acid Pharmaceutical Intermediates	询价	询价	询价	—
Unibest Taizhou GMP-like Site	(1R,2S)-2-(3,4-Difluorophenyl)cyclopropanaminium(2R)hydroxy(phenyl)ethanoate Pharmaceutical Intermediates	询价	询价	询价	—
Qualified Partner — East China API Works	Ethanol, 2-[[(3aR,4S,6R,6aS)-6-[[5-aMino-6-chloro-2-(propylthio)-4-pyriMidinyl]aMino]tetrahydro-2,2-diMethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]- Pharmaceutical Intermediates	询价	询价	询价	—
Unibest Nantong cGMP Site	(1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine hydrochloride Pharmaceutical Intermediates	询价	询价	询价	—
Unibest Taizhou GMP-like Site	Cyclopropanamine,2-(3,4-difluorophenyl)-(1R,2S) -(2R,3R)-2,3-dihydroxybutanedioate (1:1) Pharmaceutical Intermediates	询价	询价	询价	—
Qualified Partner — East China API Works	2-[[(3aS,4R,6S,6aR)-4-[7-[[(1R,2S)-2-(3,4-Difluorophenyl)cyclopropyl]amino]-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl]-2,2-dimethyl-tetrahydro-3aH-cyclopenta[d][1,3]dioxol-6-yl]oxy]ethanol Pharmaceutical Intermediates	询价	询价	询价	—

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