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CAS 180385-03-9
N-(2-(2-cyanopyridin-4-yl)-6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)pyrimidin-4-yl)-5-methylpyridine-2-sulfonamide
Codes: CLAZ-010
Application context (from source-drug indications)
动脉瘤Clazosentan SodiumIntracranial vasospasmClazosentan SodiumSubarachnoid haemorrhageClazosentan SodiumCerebral infarctionClazosentan Sodium脑缺血Clazosentan Sodium
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Clazosentan Sodium | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
isonicotinonitrile→isonicotinimidamide hydrochloride→dimethyl 2-(2-methoxyphenoxy)malonate→5-(2-methoxyphenoxy)-2-(pyridin-4-yl)pyrimidine-4,6-diol→4,6-dichloro-5-(2-methoxyphenoxy)-2-(pyridin-4-yl)pyrimidine→4-(4,6-dichloro-5-(2-methoxyphenoxy)pyrimidin-2-yl)pyridine 1-oxide→potassium ((5-methylpyridin-2-yl)sulfonyl)amide→4-(4-chloro-5-(2-methoxyphenoxy)-6-((5-methylpyridine)-2-sulfonamido)pyrimidin-2-yl)pyridine 1-oxide→4-(4-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-6-((5-methylpyridine)-2-sulfonamido)pyrimidin-2-yl)pyridine 1-oxide→N-(2-(2-cyanopyridin-4-yl)-6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)pyrimidin-4-yl)-5-methylpyridine-2-sulfonamide
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