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CAS 702-82-9
(1s,3r,5R,7S)-3-aminoadamantan-1-ol
Codes：VILD-006
Application context (from source-drug indications)
二型糖尿病维格列汀精神分裂症维格列汀血脂障碍维格列汀胰岛素抵抗维格列汀一型糖尿病维格列汀糖尿病维格列汀
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 维格列汀Vildagliptin | Tier B — Position early | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
(S)-pyrrolidine-2-carboxamide→2-chloroacetyl chloride→(S)-1-(2-chloroacetyl)pyrrolidine-2-carboxamide→N-(chloromethylene)-N-methylmethanaminium chloride→(S)-1-(2-chloroacetyl)pyrrolidine-2-carbonitrile→(1s,3r,5R,7S)-3-aminoadamantan-1-ol→(3s,5s,7s)-adamantan-1-amine→(1r,3s,5R,7S)-3-nitroadamantan-1-amine
(S)-pyrrolidine-2-carboxamide→(1s,3r,5R,7S)-3-aminoadamantan-1-ol→(3s,5s,7s)-adamantan-1-amine hydrochloride→tert-butyl 2-bromoacetate→tert-butyl ((1r,3s,5R,7S)-3-hydroxyadamantan-1-yl)glycinate→((1r,3s,5R,7S)-3-hydroxyadamantan-1-yl)glycine→(S)-pyrrolidine-2-carbonitrile→methyl L-prolinate hydrochloride
(S)-pyrrolidine-2-carboxamide→(1s,3r,5R,7S)-3-aminoadamantan-1-ol→2-oxoacetic acid→N-formyl-N-((1r,3s,5R,7S)-3-hydroxyadamantan-1-yl)glycine→(S)-1-(N-formyl-N-((1r,3R,5R,7S)-3-hydroxyadamantan-1-yl)glycyl)pyrrolidine-2-carboxamide→(1R,3r,5R,7S)-3-(N-(2-((S)-2-cyanopyrrolidin-1-yl)-2-oxoethyl)formamido)adamantan-1-yl 2,2,2-trifluoroacetate→N-(2-((S)-2-cyanopyrrolidin-1-yl)-2-oxoethyl)-N-((1r,3R,5R,7S)-3-hydroxyadamantan-1-yl)formamide
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