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CAS 4659-45-4
2,6-dichlorobenzoyl chloride
Codes：VEMF-019
Application context (from source-drug indications)
Erdheim-Chester病维罗非尼黑色素瘤维罗非尼组织细胞增生维罗非尼郎格罕细胞组织细胞增生症维罗非尼非霍奇金淋巴瘤维罗非尼肝胚细胞瘤维罗非尼
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 维罗非尼Vemurafenib | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
2,6-difluoro-3-(propylsulfonamido)benzoic acid→5-bromo-1H-pyrrolo[2,3-b]pyridine→N-(3-(5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide→(4-chlorophenyl)boronic acid→5-bromopyridin-2-amine→(E)-2-(2-ethoxyvinyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane→5-bromo-3-iodopyridin-2-amine→2,6-dichlorobenzoyl chloride→N-(3-(5-bromo-1-(2,6-dichlorobenzoyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide→N-(3-(5-(4-chlorophenyl)-1-(2,6-dichlorobenzoyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide
propane-1-sulfonyl chloride→5-bromo-1H-pyrrolo[2,3-b]pyridine→(4-chlorophenyl)boronic acid→2,6-dichlorobenzoyl chloride→N-(3-(5-(4-chlorophenyl)-1-(2,6-dichlorobenzoyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide→2,6-difluoro-3-nitrobenzoyl chloride→(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)(2,6-difluoro-3-nitrophenyl)methanone→(3-amino-2,6-difluorophenyl)(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)methanone→(3-(3-amino-2,6-difluorobenzoyl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-1-yl)(2,6-dichlorophenyl)methanone→(3-(3-amino-2,6-difluorobenzoyl)-5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)(2,6-dichlorophenyl)methanone
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