CAS 58-96-8

1-(beta-D-Ribofuranosyl)uracilUracil-1-beta-D-ribofuranoside

Codes: Molnupiravir-001

Application context (from source-drug indications)

COVID-19Molnupiravir呼吸道合胞体病毒感染MolnupiravirInfluenza virus infectionMolnupiravirRenal impairmentMolnupiravirHepatic function declineMolnupiravir

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Molnupiravir	Tier B — Position early	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

MolnupiravirOriginator routesteps: 10total yield: /

1-(beta-D-Ribofuranosyl)uracil→1-[(3aR,4R,6R,6aR)-6-(Hydroxymethyl)-2,2-dimethyl-tetrahydro-2H-furo[3,4-d][1,3]dioxol-4-yl]-1,2,3,4-tetrahydropyrimidine-2,4-dione<-fgf->2',3'-O-Isopropylideneuridine→2-Methylpropionic anhydride→2',3'-O-(1-Methylethylidene)-5'-O-(2-methylpropanoyl)uridine→N-Hydroxy-2',3'-O-(1-methylethylidene)-5'-O-(2-methylpropanoyl)cytidine→1H-1,2,4-Triazole→1-[2,3-O-(1-Methylethylidene)-5-O-(2-methylpropanoyl)-beta-D-ribofuranosyl]-4-(1H-1,2,4-triazol-1-yl)pyrimidin-2(1H)-one→1-beta-D-Ribofuranosyl-4-(1H-1,2,4-triazol-1-yl)-3,4-dihydropyrimidin-2(1H)-one→1-[2,3-O-(1-Methylethylidene)-beta-D-ribofuranosyl]-4-(1H-1,2,4-triazol-1-yl)pyrimidin-2(1H)-one→Acetone O-isobutyryloxime→1-[(2xi)-5-O-(2-Methylpropanoyl)-beta-D-erythro-pentofuranosyl]-4-(1H-1,2,4-triazol-1-yl)-3,4-dihydropyrimidin-2(1H)-one

MolnupiravirOptimised routesteps: 5total yield: 7.10g(Molnupiravir-031)

1-[(2R,3R,4R,5R)-3,4-Bis[(tert-butyldimethylsilyl)oxy]-5-{[(tert-butyldimethylsilyl)oxy]methyl}oxolan-2-yl]-1,2,3,4-tetrahydropyrimidine-2,4-dione→2',3',5'-Tris-O-[tert-butyl(dimethyl)silyl]-N-hydroxycytidine→N4-Hydroxycytidine→Uracil-1-beta-D-ribofuranoside→1-beta-D-Ribofuranosyl-4-(1H-1,2,4-triazol-1-yl)-3,4-dihydropyrimidin-2(1H)-one

MolnupiravirOptimised routesteps: 2total yield: 147g(Molnupiravir)

5’-Isobutyryluridine→Uracil-1-beta-D-ribofuranoside→Dimethylacetic anhydride

MolnupiravirOptimised routesteps: 1total yield: /

Molnupiravir-052→2,4(1H,3H)-Pyrimidinedione→1-(beta-D-Ribofuranosyl)uracil

MolnupiravirOptimised routesteps: 5total yield: 4.15g(Molnupiravir)

1-[2,3-O-(1-Methylethylidene)-5-O-(2-methylpropanoyl)-beta-D-ribofuranosyl]-4-sulfanylidene-3,4-dihydropyrimidin-2(1H)-one→1-(beta-D-Ribofuranosyl)uracil→1-[(3aR,4R,6R,6aR)-6-(Hydroxymethyl)-2,2-dimethyl-tetrahydro-2H-furo[3,4-d][1,3]dioxol-4-yl]-1,2,3,4-tetrahydropyrimidine-2,4-dione<-fgf->2',3'-O-Isopropylideneuridine→2-Methylpropionic anhydride→2',3'-O-(1-Methylethylidene)-5'-O-(2-methylpropanoyl)uridine→Hydroxylamine→N-Hydroxy-2',3'-O-(1-methylethylidene)-5'-O-(2-methylpropanoyl)cytidine

Intermediates available on this site

Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.

Supplier	Product	Price band	MOQ	Lead time	Qualifications	Action
Unibest Taizhou GMP-like Site	((3aR,4R,6R,6aR)-6-(4-(hydroxyamino)-2-oxopyrimidin-1(2H)-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl isobutyrate Pharmaceutical Intermediates	On request	On request	On request	—

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