CAS 85373-26-8,3258-02-4

N4-Hydroxycytidine

Codes: Molnupiravir-031, Molnupiravir-084

Application context (from source-drug indications)

COVID-19Molnupiravir呼吸道合胞体病毒感染MolnupiravirInfluenza virus infectionMolnupiravirRenal impairmentMolnupiravirHepatic function declineMolnupiravir

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Molnupiravir	Tier B — Position early	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

MolnupiravirOptimised routesteps: 8total yield: 77.1g(Molnupiravir)

N4-Hydroxycytidine→2-Methylpropyl 2-methylpropanoate→Ethenyl 2-methylpropanoate→1-(beta-D-Ribofuranosyl)cytosine→Acetone O-isobutyryloxime→2-Methylpropionyl chloride→5'-O-Isobutyryl cytidine→2-Methylpropionic anhydride

MolnupiravirOptimised routesteps: 5total yield: 7.10g(Molnupiravir-031)

1-[(2R,3R,4R,5R)-3,4-Bis[(tert-butyldimethylsilyl)oxy]-5-{[(tert-butyldimethylsilyl)oxy]methyl}oxolan-2-yl]-1,2,3,4-tetrahydropyrimidine-2,4-dione→2',3',5'-Tris-O-[tert-butyl(dimethyl)silyl]-N-hydroxycytidine→N4-Hydroxycytidine→Uracil-1-beta-D-ribofuranoside→1-beta-D-Ribofuranosyl-4-(1H-1,2,4-triazol-1-yl)-3,4-dihydropyrimidin-2(1H)-one

MolnupiravirOptimised routesteps: 6total yield: 3.5g(Molnupiravir-031)

2,4(1H,3H)-Pyrimidinedione→D-Ribofuranose 1,2,3,5-tetraacetate→Triacetyl uridine→4-Chloro-1-(2,3,5-tri-O-acetyl-beta-D-ribofuranosyl)pyrimidin-2(1H)-one→2',3',5'-Tri-O-acetyl-N-hydroxycytidine→N4-Hydroxycytidine

MolnupiravirOptimised routesteps: 4total yield: 42.9g(Molnupiravir)

2',3'-O-[(Dimethylamino)methylidene]-N-hydroxycytidine→2',3'-O-[(Dimethylamino)methylidene]-N-hydroxy-5'-O-(2-methylpropanoyl)cytidine→Cytosine-1-beta-D-ribofuranoside→N4-Hydroxycytidine→Isobutyric anhydride

MolnupiravirOptimised routesteps: 6total yield: 85mg(Molnupiravir)

1-(beta-D-Ribofuranosyl)cytosine<-fgf->→N4-Hydroxycytidine→Isobutyric anhydride→5'-O-(2-Methylpropanoyl)-N-[(2-methylpropanoyl)oxy]cytidine→N-[(2-Methylpropanoyl)oxy]cytidine

Intermediates available on this site

Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.

Supplier	Product	Price band	MOQ	Lead time	Qualifications	Action
Unibest Taizhou GMP-like Site	((3aR,4R,6R,6aR)-6-(4-(hydroxyamino)-2-oxopyrimidin-1(2H)-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl isobutyrate Pharmaceutical Intermediates	On request	On request	On request	—

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