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CAS 918344-20-4

(1-Hydroxycyclohexyl)(4-hydroxyphenyl)acetonitrile

Codes:DESV-021、Desvenlafaxine-018

Application context (from source-drug indications)

抑郁症琥珀酸去甲文拉法辛重度抑郁症琥珀酸去甲文拉法辛抑郁琥珀酸去甲文拉法辛糖尿病神经病变琥珀酸去甲文拉法辛疼痛琥珀酸去甲文拉法辛纤维肌痛琥珀酸去甲文拉法辛重度抑郁症地文拉法辛抑郁症地文拉法辛

Source drugs (routes using this intermediate)

DrugTierExpiry
琥珀酸去甲文拉法辛Desvenlafaxine Succinate HydrateTier C — Watch / trade-
地文拉法辛DesvenlafaxineTier C — Watch / trade-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

地文拉法辛优化路线steps: 10total yield: 82.4g(Desvenlafaxine succinate (API))
2-(4-Hydroxyphenyl)acetonitrile→Cyclohexanone→(1-Hydroxycyclohexyl)(4-hydroxyphenyl)acetonitrile→4-[2-Amino-1-(1-hydroxycyclohexyl)ethyl]phenol→2-[4-(Oxan-2-yloxy)phenyl]acetonitrile→[4-(Benzyloxy)phenyl]acetonitrile→2-(1-Hydroxycyclohexyl)-2-[4-(oxan-2-yloxy)phenyl]acetonitrile→[4-(Benzyloxy)phenyl](1-hydroxycyclohexyl)acetonitrile→Iodomethane→4-[2-(Dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenol

Intermediates available on this site

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This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.