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地文拉法辛
Tier C — Watch / tradeDesvenlafaxine
Alembic Ltd
Originator
2008
First approval
-
Expiry (public)
No sales data
Peak sales
化学药
Type
Targets：NET、SERT
Brand：Desvenlafaxine、Khedezla
Indications (approved)：重度抑郁症
Regional status
US
批准上市
2013-03-04
EU
-
China
无进展
2007-07-01
Japan
临床三期
2020-05-18
Synthetic routes & intermediates10 routes
Originator routes × 0Optimised (non-patent) × 8Process routes × 2
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
OptimisedRoute 1Steps 2 · Total yield /
| Code | CAS No. | Intermediate |
|---|---|---|
| Desvenlafaxine-001 | 93413-69-5 | Venlafaxine |
| Desvenlafaxine-002 | 99300-78-4 | Venlafaxine hydrochloride |
| Desvenlafaxine-003 | 93413-62-8 | Desvenlafaxine(O-Desnethylvenfaxine) |
OptimisedRoute 2Steps 5 · Total yield /
| Code | CAS No. | Intermediate |
|---|---|---|
| Desvenlafaxine-004 | 6547-53-1 | 2-[4-(benzyloxy)phenyl]acetic acid |
| Desvenlafaxine-005 | 39188-62-0 | 2-[4-(benzyloxy)phenyl]acetyl chloride |
| Desvenlafaxine-006 | 919475-15-3 | 2-[4-(benzyloxy)phenyl]-N,N-dimethylacetamide |
| Desvenlafaxine-007 | 108-94-1 | Cyclohexanone |
| Desvenlafaxine-008 | 955365-79-4 | 2-[4-(benzyloxy)phenyl]-2-(1-hydroxycyclohexyl)-N,N-dimethylacetamide |
| Desvenlafaxine-009 | - | 1-{1-[4-(Benzyloxy)phenyl]-2-(dimethylamino)ethyl}cyclohexan-1-ol |
OptimisedRoute 3Steps 7 · Total yield 5.8g(Desvenlafaxine (Free))
| Code | CAS No. | Intermediate |
|---|---|---|
| Desvenlafaxine-010 | 156-38-7 | 2-(4-Hydroxyphenyl)acetic acid |
| Desvenlafaxine-011 | 37859-23-7 | 2-(4-Hydroxyphenyl)acetyl chloride |
| Desvenlafaxine-012 | 124-40-3Available | Dimethylamine |
| Desvenlafaxine-013 | 76472-23-6 | 2-(4-Hydroxyphenyl)-N,N-dimethylacetamide |
| Desvenlafaxine-014 | 1004300-70-2 | 2-[4-[tert-Butyl(dimethyl)silyloxy]phenyl]-N,N-dimethylacetamide |
| Desvenlafaxine-007 | 108-94-1 | Cyclohexanone |
| Desvenlafaxine-015 | - | 2-[4-[tert-Butyl(dimethyl)silyloxy]phenyl]-2-(1-hydroxycyclohexyl)-N,N-dimethylacetamide |
| Desvenlafaxine-003 | 93413-62-8 | 4-[2-(Dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenol |
| Desvenlafaxine-016 | 1004300-76-8 | 2-(1-Hydroxycyclohexyl)-2-(4-hydroxyphenyl)-N,N-dimethylacetamide |
OptimisedRoute 4Steps 10 · Total yield 82.4g(Desvenlafaxine succinate (API))
| Code | CAS No. | Intermediate |
|---|---|---|
| Desvenlafaxine-017 | 14191-95-8 | 2-(4-Hydroxyphenyl)acetonitrile |
| Desvenlafaxine-007 | 108-94-1 | Cyclohexanone |
| Desvenlafaxine-018 | 918344-20-4 | (1-Hydroxycyclohexyl)(4-hydroxyphenyl)acetonitrile |
| Desvenlafaxine-019 | 149289-29-2 | 4-[2-Amino-1-(1-hydroxycyclohexyl)ethyl]phenol |
| Desvenlafaxine-020 | - | 2-[4-(Oxan-2-yloxy)phenyl]acetonitrile |
| Desvenlafaxine-021 | - | [4-(Benzyloxy)phenyl]acetonitrile |
| Desvenlafaxine-022 | - | 2-(1-Hydroxycyclohexyl)-2-[4-(oxan-2-yloxy)phenyl]acetonitrile |
| Desvenlafaxine-023 | - | [4-(Benzyloxy)phenyl](1-hydroxycyclohexyl)acetonitrile |
| Desvenlafaxine-024 | 74-88-4Available | Iodomethane |
| Desvenlafaxine-003 | 93413-62-8 | 4-[2-(Dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenol |
OptimisedRoute 6Steps 8 · Total yield /
| Code | CAS No. | Intermediate |
|---|---|---|
| Desvenlafaxine-025 | 16532-79-9 | 4-Bromophenylacetonitrile |
| Desvenlafaxine-026 | 9075-99-4 | Cyclohexanone,homopolymer |
| Desvenlafaxine-027 | - | 2-(4-bromophenyl)-2-(1-hydroxycyclohexyl)acetonitrile |
| Desvenlafaxine-028 | - | 1-(2-amino-1-(4-bromophenyl)ethyl)cyclohexanol |
| Desvenlafaxine-029 | - | 1-(1-(4-bromophenyl)-2-(dimethylamino)ethyl)cyclohexanol |
| Desvenlafaxine-030 | - | (4-(2-(dimethylamino)-1-(1-hydroxycyclohexyl)ethyl)phenyl)boronic acid |
| Desvenlafaxine-031 | - | 1-(1-(4-bromophenyl)-2-(dimethylamino)ethyl)cyclohexyl acetate |
OptimisedRoute 7Steps 8 · Total yield 82g(Desvenlafaxine succinate (API))
| Code | CAS No. | Intermediate |
|---|---|---|
| Desvenlafaxine-032 | 104-47-2 | 2-(4-Methoxyphenyl)acetonitrile |
| Desvenlafaxine-017 | 14191-95-8 | 2-(4-Hydroxyphenyl)acetonitrile |
| Desvenlafaxine-033 | 160192-83-6 | [4-[(2-Methoxyethoxy)methoxy]phenyl]acetonitrile |
| Desvenlafaxine-007 | 108-94-1 | Cyclohexanone |
| Desvenlafaxine-034 | 1202929-75-6 | (1-Hydroxycyclohexyl)[4-[(2-methoxyethoxy)methoxy]phenyl]acetonitrile |
| Desvenlafaxine-035 | 506-59-2 | Dimethylamine hydrochloride |
| Desvenlafaxine-036 | 1202929-76-7 | - |
| Desvenlafaxine-003 | 93413-62-8 | 4-[2-(Dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenol |
| Desvenlafaxine-018 | 918344-20-4 | (1-Hydroxycyclohexyl)(4-hydroxyphenyl)acetonitrile |
OptimisedRoute 8Steps 10 · Total yield 73.72g(Desvenlafaxine succinate (API))
| Code | CAS No. | Intermediate |
|---|---|---|
| Desvenlafaxine-032 | 104-47-2 | 2-(4-Methoxyphenyl)acetonitrile |
| Desvenlafaxine-007 | 108-94-1 | Cyclohexanone |
| Desvenlafaxine-021 | 93413-76-4 | 2-(1-Hydroxycyclohexyl)-2-(4-methoxyphenyl)acetonitrile |
| Desvenlafaxine-023 | 93413-77-5 | 1-[2-Amino-1-(4-methoxyphenyl)ethyl]cyclohexanol |
| Desvenlafaxine-022 | 130198-05-9 | 1-[2-Amino-1-(4-methoxyphenyl)ethyl]cyclohexanol hydrochloride |
| Desvenlafaxine-024 | 93413-78-6,99300-78-4 | 1-[2-(Dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexanol hydrochloride |
| Desvenlafaxine-001 | 93413-69-5 | 1-[2-(Dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexanol |
| Desvenlafaxine-003 | 93413-62-8 | 4-[2-(Dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenol |
| Desvenlafaxine-037 | 1000377-24-1 | 1-[2-(Dimethylamino)-1-[4-[(4-methoxybenzyl)oxy]phenyl]ethyl]cyclohexanol |
| Desvenlafaxine-009 | - | 1-{1-[4-(Benzyloxy)phenyl]-2-(dimethylamino)ethyl}cyclohexan-1-ol |
| Desvenlafaxine-038 | - | Butanedioic acid 1-[2-(dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexan-1-ol |
OptimisedRoute 9Steps 8 · Total yield 5.13g(Desvenlafaxine succinate (API))
| Code | CAS No. | Intermediate |
|---|---|---|
| Desvenlafaxine-039 | 99-93-4 | 1-(4-Hydroxyphenyl)ethanone |
| Desvenlafaxine-040 | 54696-05-8 | 1-[4-(Benzyloxy)phenyl]ethanone |
| Desvenlafaxine-041 | 4254-67-5 | 1-[4-(benzyloxy)phenyl]-2-bromoethan-1-one |
| Desvenlafaxine-012 | 124-40-3Available | Dimethylamine |
| Desvenlafaxine-042 | 1654001-15-6 | 1-[4-(Benzyloxy)phenyl]-2-(dimethylamino)ethanone hydrobromide |
| Desvenlafaxine-043 | 1654001-05-4 | 1-[4-(Benzyloxy)phenyl]-2-(dimethylamino)ethanol hydrochloride |
| Desvenlafaxine-044 | 1654001-18-9 | 2-[4-(Benzyloxy)phenyl]-2-chloro-N,N-dimethylethanamine hydrochloride |
| Desvenlafaxine-007 | 108-94-1 | Cyclohexanone |
| Desvenlafaxine-009 | - | 1-{1-[4-(Benzyloxy)phenyl]-2-(dimethylamino)ethyl}cyclohexan-1-ol |
| Desvenlafaxine-003 | 93413-62-8 | 4-[2-(Dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenol |
ProcessRoute 5Steps 8 · Total yield 17.8kg(Desvenlafaxine succinate (API))
| Code | CAS No. | Intermediate |
|---|---|---|
| Desvenlafaxine-021 | 93413-76-4 | 2-(1-Hydroxycyclohexyl)-2-(4-methoxyphenyl)acetonitrile |
| Desvenlafaxine-022 | 130198-05-9 | 1-[2-Amino-1-(4-methoxyphenyl)ethyl]cyclohexanol hydrochloride |
| Desvenlafaxine-023 | 93413-77-5 | 1-[2-Amino-1-(4-methoxyphenyl)ethyl]cyclohexanol |
| Desvenlafaxine-019 | 149289-29-2 | 4-[2-Amino-1-(1-hydroxycyclohexyl)ethyl]phenol |
| Desvenlafaxine-003 | 93413-62-8 | 4-[2-(Dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenol |
| Desvenlafaxine-001 | 93413-69-5 | 1-[2-(Dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexanol |
| Desvenlafaxine-024 | 93413-78-6,99300-78-4 | 1-[2-(Dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexanol hydrochloride |
ProcessRoute 10Steps 4 · Total yield 1kg(Desvenlafaxine (Free))
| Code | CAS No. | Intermediate |
|---|---|---|
| Desvenlafaxine-045 | 17362-17-3 | 3-(4-Hydroxyphenyl)propanenitrile |
| Desvenlafaxine-007 | 108-94-1 | Cyclohexanone |
| Desvenlafaxine-046 | - | 3-Cyclohexylidene-3-(4-hydroxyphenyl)propanenitrile |
| Desvenlafaxine-047 | - | [2-(4-Hydroxyphenyl)-1-oxaspiro[2.5]octan-2-yl]acetonitrile |
| Desvenlafaxine-019 | 149289-29-2 | 4-[2-Amino-1-(1-hydroxycyclohexyl)ethyl]phenol |
| Desvenlafaxine-003 | 93413-62-8 | 4-[2-(Dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenol |
Frequently asked questions
What are the approved indications of Desvenlafaxine?
Approved indications include: 重度抑郁症.
When does the Desvenlafaxine patent expire?
No public expiry year is available for Desvenlafaxine yet; this page updates once verified.
How many synthesis routes are recorded for Desvenlafaxine?
10 synthesis routes are recorded; the shortest is 2 steps with / total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Desvenlafaxine intermediates?
2 intermediate CAS of Desvenlafaxine are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Desvenlafaxine intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-24