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CAS 316173-27-0

(3aR,4R,6S,6aS)-4-((tert-butoxycarbonyl)amino)-3-(pentan-3-yl)-3a,5,6,6a-tetrahydro-4H-cyclopenta[d]isoxazole-6-carboxylic acid

Codes:PERA-016

Application context (from source-drug indications)

流感病毒感染帕拉米韦甲型流感病毒感染帕拉米韦乙型流感病毒感染帕拉米韦鼻塞帕拉米韦发热帕拉米韦咳嗽帕拉米韦

Source drugs (routes using this intermediate)

DrugTierExpiry
帕拉米韦Peramivir HydrateTier C — Watch / trade-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

帕拉米韦优化路线steps: 6total yield: 49.8 g
methyl (1S,4R)-4-((tert-butoxycarbonyl)amino)cyclopent-2-ene-1-carboxylate→methyl (3aR,4R,6S,6aS)-4-((tert-butoxycarbonyl)amino)-3-(pentan-3-yl)-3a,5,6,6a-tetrahydro-4H-cyclopenta[d]isoxazole-6-carboxylate→2-azabicyclo[2.2.1]hept-5-en-3-one→methyl (1S,4R)-4-aminocyclopent-2-ene-1-carboxylate (2R,3R)-2,3-dihydroxysuccinate→(Z)-2-ethyl-N-hydroxybutanimidoyl chloride→(3aR,4R,6S,6aS)-4-((tert-butoxycarbonyl)amino)-3-(pentan-3-yl)-3a,5,6,6a-tetrahydro-4H-cyclopenta[d]isoxazole-6-carboxylic acid→methyl (1S,2S,3S,4R)-3-((S)-1-aminoethyl)-4-((tert-butoxycarbonyl)amino)-2-hydroxycyclopentane-1-carboxylate

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